A method for correlating in vivo prostate magnetic resonance imaging and histopathology using individualized magnetic resonance-based molds.

A method for the design and rapid manufacture of a patient specific tissue slicing device based on in vivo images in order to facilitate the process of correlating the images with histopathology is presented. The method is applied to radical prostatectomy specimens where the customized mold is designed using magnetic resonance (MR) images of each patient obtained prior to surgery. In this case, the mold holds the prostate in place while a knife with a single blade or multiple blades is inserted in slots which are positioned to obtain tissue blocks corresponding to the slices in the MR images. The resulting histological specimens demonstrate good anatomical correlation with the MR images.

[1]  Sabrina S Wilson Radiology , 1938, Glasgow Medical Journal.

[2]  G. Burnstock,et al.  The innervation of the human prostate gland--the changes associated with benign enlargement. , 1991, Journal of Urology.

[3]  S. Ashley,et al.  Rapid prototyping is coming of age , 1995 .

[4]  A. Schned,et al.  Tissue-shrinkage correction factor in the calculation of prostate cancer volume. , 1996, The American journal of surgical pathology.

[5]  Hans-Peter Meinzer,et al.  Improved correlation of histological data with DCE MRI parameter maps by 3D reconstruction, reslicing and parameterization of the histological images , 2005, European Radiology.

[6]  Dimitris N. Metaxas,et al.  Automated detection of prostatic adenocarcinoma from high-resolution ex vivo MRI , 2005, IEEE Transactions on Medical Imaging.

[7]  C Cummings,et al.  Processing of radical prostatectomy specimens for correlation of data from histopathological, molecular biological, and radiological studies: a new whole organ technique , 2005, Journal of Clinical Pathology.

[8]  J Kurhanewicz,et al.  Dynamic contrast‐enhanced MRI in normal and abnormal prostate tissues as defined by biopsy, MRI, and 3D MRSI , 2005, Magnetic resonance in medicine.

[9]  Fred McBagonluri,et al.  Rapid Manufacturing in the Hearing Industry , 2006 .

[10]  P. Rogerson,et al.  Recent changes in the spatial pattern of prostate cancer in the U.S. , 2006, American journal of preventive medicine.

[11]  Ian Gibson,et al.  Advanced manufacturing technology for medical applications : reverse engineering, software conversion, and rapid prototyping , 2006 .

[12]  Silvia D. Chang,et al.  Combined diffusion‐weighted and dynamic contrast‐enhanced MRI for prostate cancer diagnosis—Correlation with biopsy and histopathology , 2006, Journal of magnetic resonance imaging : JMRI.

[13]  H. Huisman,et al.  Prostate cancer localization with dynamic contrast-enhanced MR imaging and proton MR spectroscopic imaging. , 2006, Radiology.

[14]  Magnus Hellström,et al.  Tissue shrinkage after fixation with formalin injection of prostatectomy specimens , 2006, Virchows Archiv.

[15]  Tristan Barrett,et al.  Dynamic contrast-enhanced MRI of prostate cancer at 3 T: a study of pharmacokinetic parameters. , 2007, AJR. American journal of roentgenology.

[16]  M. Reiser,et al.  Per-sextant localization and staging of prostate cancer: correlation of imaging findings with whole-mount step section histopathology. , 2007, AJR. American journal of roentgenology.

[17]  Takeo Ishigaki,et al.  Prostate cancer detection with 3-T MRI: comparison of diffusion-weighted and T2-weighted imaging. , 2007, European journal of radiology.

[18]  Masoom A Haider,et al.  Combined T2-weighted and diffusion-weighted MRI for localization of prostate cancer. , 2007, AJR. American journal of roentgenology.

[19]  Namkug Kim,et al.  Functional MR imaging of prostate cancer. , 2007, Radiographics : a review publication of the Radiological Society of North America, Inc.

[20]  D. Dearnaley,et al.  Correlation of diffusion-weighted MRI with whole mount radical prostatectomy specimens. , 2008, The British journal of radiology.

[21]  J. Nickel Inflammation and benign prostatic hyperplasia. , 2008, The Urologic clinics of North America.

[22]  M. Orth [Benign prostatic hypertrophy and the benign prostatic syndrome]. , 2008, Pharmazie in unserer Zeit.

[23]  L. Kiemeney,et al.  Changes in prostate shape and volume and their implications for radiotherapy after introduction of endorectal balloon as determined by MRI at 3T. , 2009, International journal of radiation oncology, biology, physics.