Cytotoxic T lymphocytes kill multiple targets simultaneously via spatiotemporal uncoupling of lytic and stimulatory synapses.
暂无分享,去创建一个
David Depoil | S. Valitutti | A. Wiedemann | Mustapha Faroudi | Salvatore Valitutti | D. Depoil | Aurelie Wiedemann | Mustapha Faroudi
[1] M. Poenie,et al. Dynamic polarization of the microtubule cytoskeleton during CTL-mediated killing. , 2002, Immunity.
[2] R. Duke,et al. Self recognition by T cells. I. Bystander killing of target cells bearing syngeneic MHC antigens , 1989, The Journal of experimental medicine.
[3] J. Cerottini,et al. Cell-mediated cytotoxicity, allograft rejection, and tumor immunity. , 1974, Advances in immunology.
[4] Michael Loran Dustin,et al. T Cell Receptor Signaling Precedes Immunological Synapse Formation , 2002, Science.
[5] S. Bromley,et al. The immunological synapse: a molecular machine controlling T cell activation. , 1999, Science.
[6] P. Friedl,et al. Tuning immune responses: diversity and adaptation of the immunological synapse , 2005, Nature Reviews Immunology.
[7] R Y Tsien,et al. Sequential activation and lethal hit measured by [Ca2+]i in individual cytolytic T cells and targets. , 1987, The EMBO journal.
[8] Colin R. F. Monks,et al. Three-dimensional segregation of supramolecular activation clusters in T cells , 1998, Nature.
[9] M. Poenie,et al. Real-time visualization of the cytoskeleton and effector functions in T cells. , 2004, Current opinion in immunology.
[10] K. Baetz,et al. Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re‐filling of the lytic granules and secretion of lytic proteins via a non‐granule pathway , 1995, European journal of immunology.
[11] Mark M Davis,et al. Continuous T cell receptor signaling required for synapse maintenance and full effector potential , 2003, Nature Immunology.
[12] H. Eisen,et al. Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response. , 1996, Immunity.
[13] G. Griffiths,et al. The immunological synapse of CTL contains a secretory domain and membrane bridges. , 2001, Immunity.
[14] A. Zweifach,et al. Role of calcium influx in cytotoxic T lymphocyte lytic granule exocytosis during target cell killing. , 2001, Immunity.
[15] Mark M Davis,et al. T cell killing does not require the formation of a stable mature immunological synapse , 2004, Nature Immunology.
[16] J. Lieberman,et al. Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis. , 2005, Immunity.
[17] J. Drijfhout,et al. Cross-presentation by intercellular peptide transfer through gap junctions , 2005, Nature.
[18] Becca Asquith,et al. The dynamics of T-cell fratricide: application of a robust approach to mathematical modelling in immunology. , 2003, Journal of theoretical biology.
[19] J. Yewdell,et al. Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody. , 1997, Immunity.
[20] T. Gajewski,et al. Cutting Edge: Cytotoxic Granule Polarization and Cytolysis Can Occur without Central Supramolecular Activation Cluster Formation in CD8+ Effector T Cells1 , 2005, The Journal of Immunology.
[21] Clemens Utzny,et al. Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: Manifestation of a dual activation threshold , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[22] A. Lanzavecchia,et al. Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy , 1996, The Journal of experimental medicine.
[23] Clemens Utzny,et al. Immunological synapses are versatile structures enabling selective T cell polarization. , 2005, Immunity.
[24] A. Lanzavecchia. Is the T-cell receptor involved in T-cell killing? , 1986, Nature.
[25] D. McGavern,et al. Molecular anatomy of antigen-specific CD8+ T cell engagement and synapse formation in vivo , 2002, Nature Immunology.
[26] T. Rothstein,et al. Cytotoxic T lymphocyte sequential killing of immobilized allogeneic tumor target cells measured by time-lapse microcinematography. , 1978, Journal of immunology.