Incidence of herpes simplex virus types 1 and 2 in penile lesions of college men

Herpes simplex virus (HSV) was isolated from penile lesions of 15 college men. Using (E)‐5‐(2‐bromovinyl)‐2'‐deoxyuridine sensitivity, monoclonal antibody immunofluorescence, and restriction endonuclease EcoRI digestion of viral DNA, 4 of 15 (26%) isolates were found to be HSV‐1, and 11 of 15 (74%) isolates were found to be HSV‐2. It is likely that some of the genital HSV‐1 infections are related to oral genital contact, but this fact could not be established for all cases, since the females in this group had previously been shown to have a high incidence of genital HSV‐1.

[1]  D. Zimmerman,et al.  Identification and typing of herpes simplex virus types 1 and 2 by monoclonal antibodies, sensitivity to the drug (E)‐5‐(2‐bromovinyl)‐2′‐deoxyuridine, and restriction endonuclease analysis of viral DNA , 1985, Journal of medical virology.

[2]  J. Armstrong,et al.  Characteristics and management of pregnancy in women with genital herpes simplex virus infection. , 1983, American journal of obstetrics and gynecology.

[3]  L. Corey,et al.  Primary and recurrent concomitant genital infection with herpes simplex virus types 1 and 2. , 1983, The Journal of infectious diseases.

[4]  N. Maitland,et al.  Restriction endonuclease analysis of DNA from genital isolates of herpes simplex virus type 2 , 1982, Infection and immunity.

[5]  L. Mercer,et al.  Expression of herpes simplex virus type 2 antigens in premalignant and malignant human vulvar cells. , 1982, American journal of obstetrics and gynecology.

[6]  F. Hayden,et al.  Necrotizing balanitis due to herpes simplex type 1. , 1982, Journal of the American Medical Association (JAMA).

[7]  E. Kraiselburd,et al.  Identification and typing of herpes simplex viruses with monoclonal antibodies , 1982, Journal of clinical microbiology.

[8]  J. Docherty,et al.  Inapparent genital herpes simplex virus infection in college women , 1982, Journal of medical virology.

[9]  K. Powell,et al.  Herpesvirus-induced antigens in squamous-cell carcinoma in situ of the vulva. , 1981, The New England journal of medicine.

[10]  K. Holmes,et al.  Risk of recurrence after first episodes of genital herpes. Relation to HSV type and antibody response. , 1981, The New England journal of medicine.

[11]  R. T. Walker,et al.  Differential affinities of 5-(2-halogenovinyl)-2'-deoxyuridines for deoxythymidine kinases of various origins. , 1981, Molecular pharmacology.

[12]  R. T. Walker,et al.  Comparative efficacy of antiherpes drugs against different strains of herpes simplex virus. , 1980, The Journal of infectious diseases.

[13]  R. T. Walker,et al.  (E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[14]  B. Roizman.  The structure and isomerization of herpes simplex virus genomes , 1979, Cell.

[15]  K. Holmes,et al.  Cellular immune response in genital herpes simplex virus infection. , 1978, The New England journal of medicine.

[16]  B. Roizman,et al.  Restriction endonuclease fingerprinting of herpes simplex virus DNA: a novel epidemiological tool applied to a nosocomial outbreak. , 1978, The Journal of infectious diseases.

[17]  T. Chen,et al.  In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. , 1977, Experimental cell research.

[18]  J. Docherty,et al.  Incidence and distribution of herpes simplex virus types 1 and 2 from genital lesions in college women , 1977, Journal of medical virology.

[19]  K. Holmes,et al.  Genital herpetic infection in men and women: clinical course and effect of topical application of adenine arabinoside. , 1976, The Journal of infectious diseases.

[20]  G. Hayward,et al.  Anatomy of herpes simplex virus DNA: strain differences and heterogeneity in the locations of restriction endonuclease cleavage sites. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[21]  J. Melnick,et al.  An analysis of seroepidemiological studies of herpesvirus type 2 and carcinoma of the cervix. , 1973, Cancer research.

[22]  H. Kaufman,et al.  Herpesvirus Type 2 in the Male Genitourinary Tract , 1972, Science.

[23]  W. E. Josey,et al.  Perinatal risk associated with maternal genital herpes simplex virus infection. , 1971, American journal of obstetrics and gynecology.

[24]  F. Rapp,et al.  Differential Effect of 7,12-Dimethylbenz[a]anthracene on Infectivity of Herpes Simplex Virus Type 2 1 , 1971, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[25]  A. Nahmias,et al.  Association of maternal genital herpetic infection with spontaneous abortion. , 1970 .