CRISPR screens beyond Cas9
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Two new studies in Nature Biotechnology demonstrate the feasibility of functional genomics systems beyond Cas9: a combinatorial DNA editing system involving both Cas9 and Cas12a, and an RNA-targeted system based on Cas13.
[1] Henry N. Ward,et al. Genetic interaction mapping and exon-resolution functional genomics with a hybrid Cas9–Cas12a platform , 2020, Nature Biotechnology.
[2] Neville E. Sanjana,et al. Massively parallel Cas13 screens reveal principles for guide RNA design , 2020, Nature Biotechnology.