Learning About Retinoblastoma from Mouse Models That Missed

[1]  T. Jacks,et al.  Cell type-specific effects of Rb deletion in the murine retina. , 2004, Genes & development.

[2]  T. P. Dryja,et al.  Expression of recessive alleles by chromosomal mechanisms in retinoblastoma , 1983, Nature.

[3]  L. Donoso,et al.  Retinoblastoma: messenger RNA for interphotoreceptor retinoid binding protein. , 1992, Current eye research.

[4]  D. Gombos,et al.  THE TOPOGRAPHY OF BILATERAL RETINOBLASTOMA LESIONS , 1996, Retina.

[5]  S. Jhanwar,et al.  Tumorigenesis and Neoplastic Progression Tumor-Associated Retinal Astrocytes Promote Retinoblastoma Cell Proliferation Through Production of IGFBP-5 , 2010 .

[6]  T. Triche,et al.  Retinoblastoma—origin from a primitive neuroectodermal cell? , 1984, Nature.

[7]  C. Shields,et al.  Observations on 17 patients with retinocytoma. , 2000, Archives of ophthalmology.

[8]  Lloyd Demetrius,et al.  Of mice and men , 2005, EMBO reports.

[9]  R. Weinberg,et al.  Effects of an Rb mutation in the mouse , 1992, Nature.

[10]  T. Jacks,et al.  Cooperative tumorigenic effects of germline mutations in Rb and p53 , 1994, Nature Genetics.

[11]  F. Munier,et al.  Retinoma. Case studies. , 1991, Ophthalmic paediatrics and genetics.

[12]  A. Berns,et al.  Developmental rescue of an embryonic‐lethal mutation in the retinoblastoma gene in chimeric mice. , 1994, The EMBO journal.

[13]  I. Bayazitov,et al.  Differentiated Horizontal Interneurons Clonally Expand to Form Metastatic Retinoblastoma in Mice , 2007, Cell.

[14]  T. Schwartz,et al.  Retinoblastoma. Cell of origin. , 1995, Archives of ophthalmology.

[15]  N. Dyson,et al.  p107 and p130: versatile proteins with interesting pockets. , 2001, Experimental cell research.

[16]  K. Helin,et al.  Suppression of the p53- or pRB-mediated G1 checkpoint is required for E2F-induced S-phase entry , 2002, Nature Genetics.

[17]  T. Jacks,et al.  Targeted disruption of p107: functional overlap between p107 and Rb. , 1996, Genes & development.

[18]  S. Jhanwar,et al.  Retinoblastoma Has Properties of a Cone Precursor Tumor and Depends Upon Cone-Specific MDM2 Signaling , 2009, Cell.

[19]  Stephen H. Friend,et al.  A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma , 1986, Nature.

[20]  S. Flexner A peculiar glioma (neuroepithelioma?) of the retina , 1891 .

[21]  J. Nevins,et al.  E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2. , 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[22]  A. Tarkkanen,et al.  Expression of intermediate filaments and synaptophysin show neuronal properties and lack of glial characteristics in Y79 retinoblastoma cells. , 1988, Laboratory investigation; a journal of technical methods and pathology.

[23]  R. Slack,et al.  Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma. , 2004, Cancer cell.

[24]  B. S. Fine,et al.  The nature of retinoblastoma. I. Photoreceptor differentiation: a clinical and histopathologic study. , 1970, American journal of ophthalmology.

[25]  S. Vandenberg,et al.  Expression of developmentally defined retinal phenotypes in the histogenesis of retinoblastoma. , 1992, The American journal of pathology.

[26]  A. Berns,et al.  Requirement for a functional Rb-1 gene in murine development , 1992, Nature.

[27]  R. Weinberg,et al.  Extensive contribution of Rb‐deficient cells to adult chimeric mice with limited histopathological consequences. , 1994, The EMBO journal.

[28]  M. Simon,et al.  Cone cell-specific genes expressed in retinoblastoma. , 1988, Science.

[29]  T. Jacks,et al.  Murine bilateral retinoblastoma exhibiting rapid‐onset, metastatic progression and N‐myc gene amplification , 2007, The EMBO journal.

[30]  T. Corson,et al.  Loss of RB1 induces non-proliferative retinoma: increasing genomic instability correlates with progression to retinoblastoma. , 2008, Human molecular genetics.

[31]  A. Bradley,et al.  Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis , 1992, Nature.

[32]  Robert A. Weinberg,et al.  Comparative Biology of Mouse versus Human Cells: Modelling Human Cancer in Mice O P I N I O N , 2022 .

[33]  A. Bradley,et al.  Heterozygous Rb-1 delta 20/+mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance. , 1994, Oncogene.

[34]  J. Dannenberg,et al.  Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130. , 2004, Genes & development.

[35]  A. Knudson Mutation and cancer: statistical study of retinoblastoma. , 1971, Proceedings of the National Academy of Sciences of the United States of America.

[36]  B. Gallie,et al.  Identification of germline and somatic mutations affecting the retinoblastoma gene. , 1988, Science.

[37]  M. Dyer,et al.  The First Knockout Mouse Model of Retinoblastoma , 2004 .

[38]  R. Lang,et al.  Early eye development in vertebrates. , 2001, Annual review of cell and developmental biology.

[39]  C. V. Weller The Inheritance of Retinoblastoma and Its Relationship to Practical Eugenics , 1941 .

[40]  T. Corson,et al.  One hit, two hits, three hits, more? Genomic changes in the development of retinoblastoma , 2007, Genes, chromosomes & cancer.

[41]  N. Tanimoto,et al.  Rb-Mediated Neuronal Differentiation through Cell-Cycle–Independent Regulation of E2f3a , 2007, PLoS biology.

[42]  A. Berns,et al.  p107 is a suppressor of retinoblastoma development in pRb-deficient mice. , 1998, Genes & development.

[43]  Jonathan Gray,et al.  Rb regulates proliferation and rod photoreceptor development in the mouse retina , 2004, Nature Genetics.

[44]  D. Albert Historic review of retinoblastoma. , 1987, Ophthalmology.

[45]  G. Mohapatra,et al.  Targeted expression of MYCN causes neuroblastoma in transgenic mice , 1997, The EMBO journal.