Advanced pathophysiology mimicking lung models for accelerated drug discovery

[1]  M. Cazzola,et al.  Stem Cell-Based Regenerative Therapy and Derived Products in COPD: A Systematic Review and Meta-Analysis , 2022, Cells.

[2]  Bingcheng Yi,et al.  An overview of substrate stiffness guided cellular response and its applications in tissue regeneration , 2021, Bioactive materials.

[3]  A. Aggarwal,et al.  Obstructive lung diseases burden and COVID-19 in developing countries: a perspective , 2021, Current opinion in pulmonary medicine.

[4]  J. Sznitman,et al.  Advanced human-relevant in vitro pulmonary platforms for respiratory therapeutics. , 2021, Advanced drug delivery reviews.

[5]  H. Young,et al.  Cytokines: From Clinical Significance to Quantification , 2021, Advanced science.

[6]  Rosalinde Masereeuw,et al.  The potential of multi-organ-on-chip models for assessment of drug disposition as alternative to animal testing , 2021 .

[7]  Qi Li,et al.  The Degradation of Airway Epithelial Tight Junctions in Asthma Under High Airway Pressure Is Probably Mediated by Piezo-1 , 2021, Frontiers in Physiology.

[8]  F. Kheradmand,et al.  COVID-19, COPD, and AECOPD: Immunological, Epidemiological, and Clinical Aspects , 2021, Frontiers in Medicine.

[9]  M. Bosnar,et al.  Combination of Systemic Inflammatory Biomarkers in Assessment of Chronic Obstructive Pulmonary Disease: Diagnostic Performance and Identification of Networks and Clusters , 2020, Diagnostics.

[10]  T. H. Nguyen,et al.  Prevalence and attributable health burden of chronic respiratory diseases, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 , 2020, The Lancet. Respiratory medicine.

[11]  D. Dorscheid,et al.  Structural and functional variations in human bronchial epithelial cells cultured in air liquid interface using different growth media. , 2020, American journal of physiology. Lung cellular and molecular physiology.

[12]  G. Brusselle,et al.  Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine , 2019, The Journal of pathology.

[13]  B. Relja,et al.  Cytokines in Inflammatory Disease , 2019, International journal of molecular sciences.

[14]  B. Weynand,et al.  Altered generation of ciliated cells in chronic obstructive pulmonary disease , 2019, Scientific Reports.

[15]  T. Walles,et al.  Investigation on Ciliary Functionality of Different Airway Epithelial Cell Lines in Three-Dimensional Cell Culture , 2019, Tissue engineering. Part A.

[16]  G. Norman,et al.  Limitations of Animal Studies for Predicting Toxicity in Clinical Trials: Is it Time to Rethink Our Current Approach? , 2019 .

[17]  Gail A. Van Norman,et al.  Limitations of Animal Studies for Predicting Toxicity in Clinical Trials , 2019, JACC. Basic to translational science.

[18]  H. Spits,et al.  Modeling human lung infections in mice , 2019, Nature Biotechnology.

[19]  R. Tuder,et al.  Advanced Microengineered Lung Models for Translational Drug Discovery , 2018, SLAS discovery : advancing life sciences R & D.

[20]  K. Jain Biomarkers of Pulmonary Diseases , 2017, The Handbook of Biomarkers.

[21]  A. Turner,et al.  The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD) , 2017, Respiratory Research.

[22]  Richard Novak,et al.  Matched-Comparative Modeling of Normal and Diseased Human Airway Responses Using a Microengineered Breathing Lung Chip. , 2016, Cell systems.

[23]  Jeong-Hwa Lee,et al.  Depletion of BIS sensitizes A549 cells to treatment with cisplatin , 2016, Molecular & Cellular Toxicology.

[24]  K. Nikula,et al.  Symposium Summary , 2016, International journal of toxicology.

[25]  Kyunghee Choi,et al.  Ethylene glycol potentiated didecyldimethylammonium chloride toxicity in human bronchial epithelial cells , 2015, Molecular & Cellular Toxicology.

[26]  O. Eickelberg,et al.  Cigarette smoke alters primary human bronchial epithelial cell differentiation at the air-liquid interface , 2015, Scientific Reports.

[27]  Mandy B. Esch,et al.  TEER Measurement Techniques for In Vitro Barrier Model Systems , 2015, Journal of laboratory automation.

[28]  Ram I. Sharma,et al.  The extracellular matrix: Structure, composition, age-related differences, tools for analysis and applications for tissue engineering , 2014, Journal of tissue engineering.

[29]  Jun Sun,et al.  Pulmonary Permeability Assessed by Fluorescent-Labeled Dextran Instilled Intranasally into Mice with LPS-Induced Acute Lung Injury , 2014, PloS one.

[30]  A. Holland,et al.  Clinical issues of mucus accumulation in COPD , 2014, International journal of chronic obstructive pulmonary disease.

[31]  Saumya Das,et al.  Extracellular Vesicles in Heart Disease: Excitement for the Future ? , 2014, Exosomes and microvesicles.

[32]  R. Devlin,et al.  Growth of human bronchial epithelial cells at an air-liquid interface alters the response to particle exposure , 2013, Particle and Fibre Toxicology.

[33]  M. Peitsch,et al.  Human bronchial epithelial cells exposed in vitro to cigarette smoke at the air-liquid interface resemble bronchial epithelium from human smokers. , 2013, American journal of physiology. Lung cellular and molecular physiology.

[34]  Yoshihiro Kawaoka,et al.  CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin. , 2013, American journal of respiratory and critical care medicine.

[35]  Sang Yup Lee,et al.  The effects of the physical properties of culture substrates on the growth and differentiation of human embryonic stem cells. , 2011, Biomaterials.

[36]  P. Howarth,et al.  Defective epithelial barrier function in asthma. , 2011, The Journal of allergy and clinical immunology.

[37]  J. Wedzicha,et al.  Serum IP-10 as a biomarker of human rhinovirus infection at exacerbation of COPD. , 2010, Chest.

[38]  Simon Festing,et al.  The ethics of animal research , 2007, EMBO reports.

[39]  K. Omori,et al.  Effect of fibroblasts on tracheal epithelial regeneration in vitro. , 2006, Tissue engineering.

[40]  Y. Guan,et al.  Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells , 2005, Respiratory research.

[41]  J. Bates,et al.  Measuring the lung function in the mouse: the challenge of size , 2003, Respiratory research.

[42]  J. Finkelstein,et al.  Pulmonary cytokine and chemokine mRNA levels after inhalation of lipopolysaccharide in C57BL/6 mice. , 1998, Toxicological sciences : an official journal of the Society of Toxicology.

[43]  M. Yamaya,et al.  Differentiated structure and function of cultures from human tracheal epithelium. , 1992, The American journal of physiology.

[44]  Ada T Feldman,et al.  Tissue processing and hematoxylin and eosin staining. , 2014, Methods in molecular biology.

[45]  T. Scheetz,et al.  The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia. , 2011, American journal of physiology. Lung cellular and molecular physiology.

[46]  Hilde van der Togt,et al.  Publisher's Note , 2003, J. Netw. Comput. Appl..

[47]  J A Cooper,et al.  On the use of animals in scientific research. , 1980, Journal of medical education.