Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

[1]  H. Boehmer,et al.  Mechanisms of suppression by suppressor T cells , 2005, Nature Immunology.

[2]  A. Rudensky,et al.  A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3 , 2005, Nature Immunology.

[3]  Shimon Sakaguchi,et al.  Homeostatic maintenance of natural Foxp3 + CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization , 2005, The Journal of experimental medicine.

[4]  H. Waldmann,et al.  Regulatory T cells in transplantation tolerance. , 2005, Current topics in microbiology and immunology.

[5]  S. Sakaguchi,et al.  Control of Foxp3+ CD25+CD4+ regulatory cell activation and function by dendritic cells. , 2004, International immunology.

[6]  M. Neurath,et al.  Cutting Edge: TGF-β Signaling Is Required for the In Vivo Expansion and Immunosuppressive Capacity of Regulatory CD4+CD25+ T Cells1 , 2004, The Journal of Immunology.

[7]  J. Bluestone,et al.  Distinct roles of CTLA‐4 and TGF‐β in CD4+CD25+ regulatory T cell function , 2004 .

[8]  R. Medzhitov,et al.  Toll-dependent control mechanisms of CD4 T cell activation. , 2004, Immunity.

[9]  T. Nomura,et al.  Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells. , 2004, International immunology.

[10]  V. Kuchroo,et al.  Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[11]  Ethan M. Shevach,et al.  Engagement of Glucocorticoid-Induced TNFR Family-Related Receptor on Effector T Cells by its Ligand Mediates Resistance to Suppression by CD4+CD25+ T Cells , 2004, The Journal of Immunology.

[12]  G. Szot,et al.  Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells. , 2004, The Journal of clinical investigation.

[13]  Clare Baecher-Allan,et al.  Suppressor T Cells in Human Diseases , 2004, The Journal of experimental medicine.

[14]  A. Rudensky,et al.  Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors. , 2004, Immunity.

[15]  R. Schreiber,et al.  The immunobiology of cancer immunosurveillance and immunoediting. , 2004, Immunity.

[16]  S. Sakaguchi,et al.  Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells. , 2004, International immunology.

[17]  B. Levine,et al.  In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures. , 2004, Blood.

[18]  Linrong Lu,et al.  Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[19]  R. Andreesen,et al.  Large scale in vitro expansion of polyclonal human CD4+CD25high regulatory T cells , 2004, Cancer Cell International.

[20]  I. Ishikawa,et al.  Costimulation via Glucocorticoid-Induced TNF Receptor in Both Conventional and CD25+ Regulatory CD4+ T Cells1 , 2004, The Journal of Immunology.

[21]  R. Steinman,et al.  CD25+ CD4+ T Cells, Expanded with Dendritic Cells Presenting a Single Autoantigenic Peptide, Suppress Autoimmune Diabetes , 2004, The Journal of experimental medicine.

[22]  Jeffrey A. Bluestone,et al.  In Vitro–expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes , 2004, The Journal of experimental medicine.

[23]  Ethan M. Shevach,et al.  Cutting Edge: IL-2 Is Critically Required for the In Vitro Activation of CD4+CD25+ T Cell Suppressor Function , 2004, The Journal of Immunology.

[24]  W. Faubion,et al.  Cutting Edge: The Natural Ligand for Glucocorticoid-Induced TNF Receptor-Related Protein Abrogates Regulatory T Cell Suppression 1 , 2004, The Journal of Immunology.

[25]  H. Waldmann,et al.  Regulatory T cells and organ transplantation. , 2004, Seminars in immunology.

[26]  D. Munn,et al.  Ligation of B7-1/B7-2 by Human CD4+ T Cells Triggers Indoleamine 2,3-Dioxygenase Activity in Dendritic Cells1 , 2004, The Journal of Immunology.

[27]  R. Flavell,et al.  TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[28]  S. Sakaguchi.  Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. , 2004, Annual review of immunology.

[29]  D. Sansom,et al.  CD86 and CD80 Differentially Modulate the Suppressive Function of Human Regulatory T Cells1 , 2004, The Journal of Immunology.

[30]  A. G. Betz,et al.  Regulatory T cells mediate maternal tolerance to the fetus , 2004, Nature Immunology.

[31]  C. Yee,et al.  Autoreactive T Cells in Healthy Individuals , 2004 .

[32]  金丸 史子.  Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25[+] regulatory CD4[+] T cells , 2004 .

[33]  J. Bluestone,et al.  Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function. , 2004, European journal of immunology.

[34]  T. Utsugi,et al.  CD40 ligation releases immature dendritic cells from the control of regulatory CD4+CD25+ T cells. , 2003, Immunity.

[35]  H. Waldmann,et al.  Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[36]  U. Grohmann,et al.  Modulation of tryptophan catabolism by regulatory T cells , 2003, Nature Immunology.

[37]  J. Bluestone,et al.  Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells 1 , 2003, The Journal of Immunology.

[38]  D. Klatzmann,et al.  Continuous Activation of Autoreactive CD4+ CD25+ Regulatory T Cells in the Steady State , 2003, The Journal of experimental medicine.

[39]  H. Ikeda,et al.  CD4+ CD25+ T cells responding to serologically defined autoantigens suppress antitumor immune responses , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[40]  R. Steinman,et al.  Direct Expansion of Functional CD25+ CD4+ Regulatory T Cells by Antigen-processing Dendritic Cells , 2003, The Journal of experimental medicine.

[41]  Anna Chodos,et al.  Antigen-dependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo , 2003, The Journal of experimental medicine.

[42]  L. Klein,et al.  In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[43]  H. Ochs,et al.  Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis , 2003, Current opinion in rheumatology.

[44]  Thomas A. Davis,et al.  Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[45]  Luc J. Smink,et al.  Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease , 2003, Nature.

[46]  F. Ramsdell,et al.  An essential role for Scurfin in CD4+CD25+ T regulatory cells , 2003, Nature Immunology.

[47]  A. Rudensky,et al.  Foxp3 programs the development and function of CD4+CD25+ regulatory T cells , 2003, Nature Immunology.

[48]  I. Caramalho,et al.  Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide , 2003, The Journal of experimental medicine.

[49]  Ruslan Medzhitov,et al.  Toll Pathway-Dependent Blockade of CD4+CD25+ T Cell-Mediated Suppression by Dendritic Cells , 2003, Science.

[50]  T. Nomura,et al.  Control of Regulatory T Cell Development by the Transcription Factor Foxp3 , 2002 .

[51]  A. Rudensky,et al.  Foxp 3 programs the development and function of CD 4 + CD 25 + regulatory T cells , 2003 .

[52]  A. Freitas,et al.  Homeostasis of Peripheral CD4+ T Cells: IL-2Rα and IL-2 Shape a Population of Regulatory Cells That Controls CD4+ T Cell Numbers1 , 2002, The Journal of Immunology.

[53]  T. Elliott,et al.  Depletion of CD25+ regulatory cells uncovers immune responses to shared murine tumor rejection antigens , 2002, European journal of immunology.

[54]  P. Blair,et al.  Inhibition of human T cell proliferation by CTLA‐4 utilizes CD80 and requires CD25+ regulatory T cells , 2002, European journal of immunology.

[55]  R. Badolato,et al.  X‐chromosome inactivation analysis in a female carrier of FOXP3 mutation , 2002, Clinical and experimental immunology.

[56]  J. Bach,et al.  The effect of infections on susceptibility to autoimmune and allergic diseases. , 2002, The New England journal of medicine.

[57]  J. Lafaille,et al.  Interleukin 2 Signaling Is Required for CD4+ Regulatory T Cell Function , 2002, The Journal of experimental medicine.

[58]  E. Zackai,et al.  CD4+ CD25+ T-Cell Production in Healthy Humans and in Patients with Thymic Hypoplasia , 2002, Clinical and Vaccine Immunology.

[59]  T. Malek,et al.  CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. , 2002, Immunity.

[60]  Andrea Iaboni,et al.  The interaction properties of costimulatory molecules revisited. , 2002, Immunity.

[61]  P. Pandolfi,et al.  Role of GITR in activation response of T lymphocytes. , 2002, Blood.

[62]  Akemi Sakamoto,et al.  CD25+CD4+ T cells contribute to the control of memory CD8+ T cells , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[63]  Ethan M. Shevach,et al.  Cutting Edge: Depletion of CD4+CD25+ Regulatory T Cells Is Necessary, But Not Sufficient, for Induction of Organ-Specific Autoimmune Disease , 2002, The Journal of Immunology.

[64]  M. Byrne,et al.  CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. , 2002, Immunity.

[65]  J. Shimizu,et al.  Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance , 2002, Nature Immunology.

[66]  T. Schumacher,et al.  Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses , 2001, The Journal of experimental medicine.

[67]  W. Strober,et al.  Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β , 2001, The Journal of experimental medicine.

[68]  F. Powrie,et al.  Control of intestinal inflammation by regulatory T cells. , 2001, Microbes and infection.

[69]  F. Powrie,et al.  Regulatory T cells in the control of immune pathology , 2001, Nature Immunology.

[70]  I. Caramalho,et al.  Regulatory T cells: the physiology of autoreactivity in dominant tolerance and “quality control” of immune responses , 2001, Immunological reviews.

[71]  T. Hünig,et al.  Control of T cell hyperactivation in IL‐2‐deficient mice by CD4+CD25– and CD4+CD25+ T cells: evidence for two distinct regulatory mechanisms , 2001, European journal of immunology.

[72]  H. Kikutani,et al.  Increased T Cell Autoreactivity in the Absence of CD40-CD40 Ligand Interactions: A Role of CD40 in Regulatory T Cell Development1 , 2001, The Journal of Immunology.

[73]  H. Ochs,et al.  The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3 , 2001, Nature Genetics.

[74]  J. Casanova,et al.  X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy , 2001, Nature Genetics.

[75]  D. Galas,et al.  Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse , 2001, Nature Genetics.

[76]  A. Bowcock,et al.  JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. , 2000, The Journal of clinical investigation.

[77]  D. Mason,et al.  CD25 Is a Marker for CD4+ Thymocytes That Prevent Autoimmune Diabetes in Rats, But Peripheral T Cells with This Function Are Found in Both CD25+ and CD25− Subpopulations1 , 2000, The Journal of Immunology.

[78]  T. Mak,et al.  Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4 , 2000, The Journal of experimental medicine.

[79]  Fiona Powrie,et al.  Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation , 2000, The Journal of experimental medicine.

[80]  J. Todd,et al.  Differential glycosylation of interleukin 2, the molecular basis for the NOD Idd3 type 1 diabetes gene? , 2000, Cytokine.

[81]  J. Bluestone,et al.  B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. , 2000, Immunity.

[82]  E. Shevach.  Regulatory T cells in autoimmmunity*. , 2000, Annual review of immunology.

[83]  J. Shimizu,et al.  Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity. , 1999, Journal of immunology.

[84]  T. Mak,et al.  Cutting edge: lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous. , 1999, Journal of immunology.

[85]  T. Fujita,et al.  Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. , 1999, Cancer research.

[86]  F. Otsuka,et al.  Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. , 1999, Journal of immunology.

[87]  J. Seidman,et al.  QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing Il2 , 1999, Nature Genetics.

[88]  鬼塚 正三郎.  Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor α) monoclonal antibody , 1999 .

[89]  M. Toda,et al.  Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. , 1998, International immunology.

[90]  Ethan M. Shevach,et al.  CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production , 1998, The Journal of experimental medicine.

[91]  E. Shevach,et al.  CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. , 1998, Journal of immunology.

[92]  B. Nelson,et al.  Biology of the interleukin-2 receptor. , 1998, Advances in immunology.

[93]  Hervé Groux,et al.  A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis , 1997, Nature.

[94]  I. Autenrieth,et al.  Interleukin-2 is indispensable for development of immunological self-tolerance. , 1996, Clinical immunology and immunopathology.

[95]  S. Sakaguchi,et al.  Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation , 1996, The Journal of experimental medicine.

[96]  Toshitada Takahashi,et al.  Administration of anti‐interleukin‐2 receptor α antibody in vivo induces localized autoimmune disease , 1996, European journal of immunology.

[97]  K. Sugamura,et al.  Lack of intermediate‐affinity interleukin‐2 receptor in mice leads to dependence on interleukin‐2 receptor α, β and γ chain expression for T cell growth , 1996 .

[98]  Kendall A. Smith,et al.  Interleukin‐2 Deficient Mice: A New Model to Study Autoimmunity and Self‐Tolerance , 1995, Immunological reviews.

[99]  T. Hünig,et al.  Immunopathology of interleukin (IL) 2-deficient mice: thymus dependence and suppression by thymus-dependent cells with an intact IL-2 gene , 1995, The Journal of experimental medicine.

[100]  H. Griesser,et al.  Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4 , 1995, Science.

[101]  J. Bluestone,et al.  Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. , 1995, Immunity.

[102]  F. Alt,et al.  Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. , 1995, Immunity.

[103]  M. Toda,et al.  Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. , 1995, Journal of immunology.

[104]  H. Griesser,et al.  Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. , 1995, Science.

[105]  H. Weiner,et al.  Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. , 1994, Science.

[106]  P. Bruggen,et al.  Tumor antigens recognized by T lymphocytes. , 1994, Annual review of immunology.

[107]  D. Mason,et al.  OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset [published erratum appears in J Exp Med 1991 Apr 1;173(4):1037] , 1990, The Journal of experimental medicine.

[108]  D. Greiner,et al.  Adoptive transfer of autoimmune diabetes and thyroiditis to athymic rats. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[109]  M. Adinolfi.  of Immune Responses , 1989 .

[110]  P Rubinstein,et al.  Diabetes mellitus and autoimmunity in patients with the congenital rubella syndrome. , 1985, Reviews of infectious diseases.

[111]  S. Sakaguchi,et al.  Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease , 1985, The Journal of experimental medicine.

[112]  D. H. Besterfield.  Quality control , 1979 .