Clinical Efficacy of Low-Dose, Long-Term Treatment with Roxithromycin for Otitis Media with Effusion.

We evaluated the efficacy of treatment with roxithromycin (RXM: new derivative of erythromycin) for OME patients with tympanostomy tube (TT) from the perspective of reducing refractory OME and preventing complications.Seventeen ears of 15 patients were treated for 6 months with a single daily dose (150mg) of RXM starting on the day of TT insertion. The other 23 ears of 20 patients were treated by TT insertion only.The rate of improvement, including “good” improvement, for ears with mucous fluid in the middle ear and poor mastoid pneumatization was significantly higher in ears treated with RXM (50%, 60%) than in ears treated with TT insertion alone (0%, 25%).These results indicate that low-dose RXM treatment may be useful for OME requiring TT insertion, and in reducing complications caused by TT insertion.

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