论文信息 - Cross-Reactivity ofNonspecific Treponemal Antibody inSerologic Tests forLymeDisease

Cross-Reactivity ofNonspecific Treponemal Antibody inSerologic Tests forLymeDisease

staining methods. Although there werepositive reactions forserarepresenting eachofthese study groupsandfor20(13%)of156samples collected fromthegeneral population (premarital screening forsyphilis), titration endpoints wererelatively low (.1:256). Serumsamples from18personswhohadgingivitis orperiodontitis butnohistory ofLymeborreliosis weretested byenzyme-linked immunosorbent assayforantibodies toBorrelia burgdorferi. Ofthese, five (28%) hadimmunoglobulin M antibody andfour(22%)contained immunoglobulin G antibodies tothis spirochete. Adsorption witheither sorbent commercially prepared fromT.phagedenis biotype Reiter or withwashed, wholecells ofT.phagedenis biotype Reiter reduced cross-reactivity intheenzyme-linked immunosorbent assay forLymeborreliosis.

John F Anderson | G. Riviere

[1] H. Pfister,et al. Serological diagnosis of erythema migrans disease and related disorders , 1984, Infection.

[2] Wei Jiang. Biochemical andImmunological Characterization oftheSurface Proteins ofBorrelia burgdorferi , 1989 .

[3] K. Hansen,et al. Measurement ofAntibodies totheBorrelia burgdorferi Flagellum Improves Serodiagnosis inLymeDisease , 1988 .

[4] H. Morton. Quantitative Relationship ofTreponema denticola toSeverity ofPeriodontal Disease , 1988 .

[5] J. Radolf,et al. The antigenic interrelationship between the endoflagella of Treponema phagedenis biotype Reiter and Treponema pallidum Nichols strain. I. Treponemicidal activity of cross-reactive endoflagellar antibodies against T. pallidum. , 1986, Journal of immunology.

[6] B. Hederstedt,et al. The spirochetal etiology of erythema chronicum migrans Afzelius. , 1984, Acta dermato-venereologica.

[7] B. Hederstedt,et al. The spirochetal etiology of acrodermatitis chronica atrophicans Herxheimer. , 1984, Acta dermato-venereologica.

[8] Dennis F. Mangan,et al. InVitro Lymphocyte Blastogenic Responses andTiters of Humoral Antibodies fromPeriodontitis Patients toOral Spirochete Isolates , 1982 .

[9] W. Moore,et al. Bacteriology ofExperimental Gingivitis inYoungAdult Humans , 1982 .