论文信息 - The Importance of Testing Anti‐IL‐17 Antibodies From Different Suppliers

The Importance of Testing Anti‐IL‐17 Antibodies From Different Suppliers

With great interest, we have read the study by Loverre et al. The authors show by means of immunostaining that numerous IL-17+CD4+ cells are present in renal biopsies during T-cell-mediated rejection (TCMR) and demonstrate that tubular epithelial cells (TECs) represent a significant source for IL-17 in antibody-mediated rejection (ABMR; Ref. 1). We have some concerns regarding the specificity of the immunostaining.

S. Florquin | J. Roelofs | Ü. Yapici

[1] I. T. Ten Berge,et al. Interleukin‐17 positive cells accumulate in renal allografts during acute rejection and are independent predictors of worse graft outcome , 2011, Transplant international : official journal of the European Society for Organ Transplantation.

[2] L. Gesualdo,et al. IL‐17 Expression by Tubular Epithelial Cells in Renal Transplant Recipients with Acute Antibody‐Mediated Rejection , 2011, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[3] P. Teeling,et al. Overrepresentation of IL-17A and IL-22 Producing CD8 T Cells in Lesional Skin Suggests Their Involvement in the Pathogenesis of Psoriasis , 2010, PloS one.

[4] P. Teeling,et al. Differential expression of interleukin‐17 family cytokines in intact and complicated human atherosclerotic plaques , 2010, The Journal of pathology.