Synthesis of 1-Substituted Indole-3-Carboxaldehyde related to Acyclic Nucleosides and their Condensed Pyrenyl Derivatives

Indole-3-carboxaldehyde was N-alkylated to give the corresponding acyclic nucleosides 3a–h which were condensed with 1-pyrenamine and 1-acetylpyrene to give 5a,c,e–g and 7b–d,e,g, respectively. The Schiff's bases 5a and 5e with 2-hydroxyethyl and methylthiomethyl N-1 substituents were found moderately active against HIV-1.