Multifunctional Nanoparticles as Biocompatible Targeted Probes for Human Cancer Diagnosis and Therapy.

The use of nanoparticles in biological application has been rapidly advancing toward practical applications in human cancer diagnosis and therapy. Upon linking the nanoparticles with biomolecules, they can be used to locate cancerous area as well as for traceable drug delivery with high affinity and specificity. In this review, we discuss the engineering of multifunctional nanoparticle probes and their use in bioimaging and nanomedicine.

[1]  A. Alivisatos.  Perspectives on the Physical Chemistry of Semiconductor Nanocrystals , 1996 .

[2]  Saed Mirzadeh,et al.  The fate of MAb-targeted Cd(125m)Te/ZnS nanoparticles in vivo. , 2008, Nuclear medicine and biology.

[3]  W. Tan,et al.  Ultrafine biocompatible chitosan nanoparticles encapsulating multi-coloured quantum dots for bioapplications. , 2007, Journal of colloid and interface science.

[4]  S. Gambhir,et al.  Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics , 2005, Science.

[5]  W. Webb,et al.  Water-Soluble Quantum Dots for Multiphoton Fluorescence Imaging in Vivo , 2003, Science.

[6]  M. Swihart,et al.  Surface functionalization of silicon nanoparticles produced by laser-driven pyrolysis of silane followed by HF-HNO3 etching. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[7]  Hongwei Liao and,et al.  Gold Nanorod Bioconjugates , 2005 .

[8]  Chad A Mirkin,et al.  A gold nanoparticle based approach for screening triplex DNA binders. , 2006, Journal of the American Chemical Society.

[9]  Indrajit Roy,et al.  Organically modified silica nanoparticles with covalently incorporated photosensitizer for photodynamic therapy of cancer. , 2007, Nano letters.

[10]  Catherine J. Murphy,et al.  Seed-Mediated Synthesis of Gold Nanorods: Role of the Size and Nature of the Seed , 2004 .

[11]  Charles Nicholson,et al.  In vivo diffusion analysis with quantum dots and dextrans predicts the width of brain extracellular space. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[12]  M. Kuno,et al.  Band-filling of solution-synthesized CdS nanowires. , 2008, ACS nano.

[13]  Vladimir P Torchilin,et al.  Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo , 2005, Nature Medicine.

[14]  Wen-Tso Liu,et al.  Nanoparticles and their biological and environmental applications. , 2006, Journal of bioscience and bioengineering.

[15]  M. Bawendi,et al.  Type-II quantum dots: CdTe/CdSe(core/shell) and CdSe/ZnTe(core/shell) heterostructures. , 2003, Journal of the American Chemical Society.

[16]  Jun Jiao,et al.  Synthesis, Characterization, and Growth Mechanism of Self-Assembled Dendritic CdS Nanorods , 2004 .

[17]  Jennifer Sturgis,et al.  A cellular Trojan Horse for delivery of therapeutic nanoparticles into tumors. , 2007, Nano letters.

[18]  P. Kamat,et al.  Exciton recombination dynamics in CdSe nanowires: bimolecular to three-carrier Auger kinetics. , 2006, Nano letters.

[19]  Rebekah Drezek,et al.  Water-soluble quantum dots for biomedical applications. , 2006, Biochemical and biophysical research communications.

[20]  Tomonobu M. Watanabe,et al.  Reduction in nonfluorescence state of quantum dots on an immunofluorescence staining. , 2006, Biochemical and biophysical research communications.

[21]  Moungi G Bawendi,et al.  Ternary I-III-VI quantum dots luminescent in the red to near-infrared. , 2008, Journal of the American Chemical Society.

[22]  Ling Chen,et al.  The solventless syntheses of unique PbS nanowires of X-shaped cross sections and the cooperative effects of ethylenediamine and a second salt. , 2007, Inorganic chemistry.

[23]  C. Mirkin,et al.  Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles. , 2007, Nano letters.

[24]  K. Jensen,et al.  Synthesis of Luminescent Thin-Film CdSe/ZnSe Quantum Dot Composites Using CdSe Quantum Dots Passivated with an Overlayer of ZnSe , 1996 .

[25]  Tatsuro Endo,et al.  Quantum dot-based immunosensor for the detection of prostate-specific antigen using fluorescence microscopy. , 2007, Talanta.

[26]  Raheela Ashfaq,et al.  Claudin 4 Protein Expression in Primary and Metastatic Pancreatic Cancer , 2004 .

[27]  A Paul Alivisatos,et al.  Semiconductor quantum rods as single molecule fluorescent biological labels. , 2007, Nano letters.

[28]  Cherie R. Kagan,et al.  Self-Organization of CdSe Nanocrystallites into Three-Dimensional Quantum Dot Superlattices , 1995, Science.

[29]  R. Weissleder,et al.  Imaging pancreatic cancer with a peptide-nanoparticle conjugate targeted to normal pancreas. , 2006, Bioconjugate chemistry.

[30]  S. Bhatia,et al.  Probing the Cytotoxicity Of Semiconductor Quantum Dots. , 2004, Nano letters.

[31]  P. Prasad,et al.  Hybrid Quantum‐Dot–Polymer Nanocomposites for Infrared Photorefractivity at an Optical Communication Wavelength , 2005 .

[32]  Moungi G Bawendi,et al.  Oligomeric ligands for luminescent and stable nanocrystal quantum dots. , 2003, Journal of the American Chemical Society.

[33]  Steffen Hackbarth,et al.  Long-term exposure to CdTe quantum dots causes functional impairments in live cells. , 2007, Langmuir : the ACS journal of surfaces and colloids.

[34]  Ming-Hsien Tsai,et al.  Persistent Tissue Kinetics and Redistribution of Nanoparticles, Quantum Dot 705, in Mice: ICP-MS Quantitative Assessment , 2007, Environmental health perspectives.

[35]  Liberato Manna,et al.  Controlled growth of tetrapod-branched inorganic nanocrystals , 2003, Nature materials.

[36]  Mark T Swihart,et al.  Efficient surface grafting of luminescent silicon quantum dots by photoinitiated hydrosilylation. , 2005, Langmuir : the ACS journal of surfaces and colloids.

[37]  Shimon Weiss,et al.  Advances in fluorescence imaging with quantum dot bio-probes. , 2006, Biomaterials.

[38]  P. Alivisatos.  The use of nanocrystals in biological detection , 2004, Nature Biotechnology.

[39]  Xiaohua Huang,et al.  Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: applications in oral cancer. , 2005, Nano letters.

[40]  S. Chaudhuri,et al.  Synthesis and Optical and Electrical Properties of CdS/ZnS Core/Shell Nanorods , 2007 .

[41]  Frederick R Haselton,et al.  Surface engineering of quantum dots for in vivo vascular imaging. , 2007, Bioconjugate chemistry.

[42]  P. Singh,et al.  Virus-based nanoparticles (VNPs): platform technologies for diagnostic imaging. , 2006, Advanced drug delivery reviews.

[43]  Jae Hee Song,et al.  Photochemical synthesis of gold nanorods. , 2002, Journal of the American Chemical Society.

[44]  U. Banin,et al.  Folate-mediated tumor cell uptake of quantum dots entrapped in lipid nanoparticles. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[45]  Rebecca Richards-Kortum,et al.  Fluorescent nanocrystals for use in early cervical cancer detection. , 2005, Gynecologic oncology.

[46]  Petras Juzenas,et al.  Quantum dots and nanoparticles for photodynamic and radiation therapies of cancer. , 2008, Advanced drug delivery reviews.

[47]  Phil G Campbell,et al.  The use of quantum dots for analysis of chick CAM vasculature. , 2007, Microvascular research.

[48]  Hans C. Fischer,et al.  Design and characterization of lysine cross-linked mercapto-acid biocompatible quantum dots , 2006 .

[49]  V. Protasenko,et al.  Solution-Based Straight and Branched CdTe Nanowires , 2004 .

[50]  Earl J. Bergey,et al.  Nanochemistry: Synthesis and Characterization of Multifunctional Nanoclinics for Biological Applications , 2002 .

[51]  R. Pereiro,et al.  The use of luminescent quantum dots for optical sensing , 2006 .

[52]  C. Murphy.  Nanocubes and Nanoboxes , 2002, Science.

[53]  T. Mihaljevic,et al.  Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping , 2004, Nature Biotechnology.

[54]  C. Murphy,et al.  Room temperature, high-yield synthesis of multiple shapes of gold nanoparticles in aqueous solution. , 2004, Journal of the American Chemical Society.

[55]  Shuming Nie,et al.  Bioconjugated quantum dots for in vivo molecular and cellular imaging. , 2008, Advanced drug delivery reviews.

[56]  P. Prasad,et al.  Shape Control of CdS Nanocrystals in One-Pot Synthesis , 2007 .

[57]  C. Murphy,et al.  Dependence of the Gold Nanorod Aspect Ratio on the Nature of the Directing Surfactant in Aqueous Solution , 2003 .

[58]  Mark T. Swihart,et al.  Process for preparing macroscopic quantities of brightly photoluminescent silicon nanoparticles with emission spanning the visible spectrum , 2003 .

[59]  David A. Russell,et al.  Bacterial detection using carbohydrate-functionalised CdS quantum dots: a model study exploiting E. coli recognition of mannosides , 2009 .

[60]  Xiaogang Peng,et al.  Kinetics of II-VI and III-V Colloidal Semiconductor Nanocrystal Growth: “Focusing” of Size Distributions , 1998 .

[61]  J. Ying,et al.  Synthesis and Cell‐Imaging Applications of Glutathione‐Capped CdTe Quantum Dots , 2007 .

[62]  Kenji Yamamoto,et al.  The Microemulsion Synthesis of Hydrophobic and Hydrophilic Silicon Nanocrystals , 2006 .

[63]  Zhanfang Ma,et al.  One-step synthesis of cystine-coated gold nanoparticles in aqueous solution , 2008 .

[64]  Xavier Michalet,et al.  New light on quantum dot cytotoxicity. , 2005, Chemistry & biology.

[65]  Anupam Singhal,et al.  Assessing Near-Infrared Quantum Dots for Deep Tissue, Organ, and Animal Imaging Applications , 2008 .

[66]  M. Descour,et al.  Molecular optical imaging of therapeutic targets of cancer. , 2006, Advances in cancer research.

[67]  J. K. Park,et al.  The modification of quantum dot probes used for the targeted imaging of his-tagged fusion proteins. , 2009, Biomaterials.

[68]  Xiaogang Peng,et al.  Alternative Routes toward High Quality CdSe Nanocrystals , 2001 .

[69]  Tymish Y. Ohulchanskyy,et al.  Optical tracking of organically modified silica nanoparticles as DNA carriers: a nonviral, nanomedicine approach for gene delivery. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[70]  P. Prasad,et al.  Shape control of PbSe nanocrystals using noble metal seed particles. , 2006, Nano letters.

[71]  M. Swihart,et al.  Templated Synthesis of Gold Nanorods (NRs): The Effects of Cosurfactants and Electrolytes on the Shape and Optical Properties , 2008 .

[72]  Eli Ruckenstein,et al.  Water-Soluble Poly(acrylic acid) Grafted Luminescent Silicon Nanoparticles and Their Use as Fluorescent Biological Staining Labels , 2004 .

[73]  John V Frangioni,et al.  Size series of small indium arsenide-zinc selenide core-shell nanocrystals and their application to in vivo imaging. , 2006, Journal of the American Chemical Society.

[74]  Shuming Nie,et al.  Emerging use of nanoparticles in diagnosis and treatment of breast cancer. , 2006, The Lancet. Oncology.

[75]  B. Kang,et al.  Synthesis of green CdSe/chitosan quantum dots using a polymer-assisted γ-radiation route , 2008 .

[76]  Mostafa A. El-Sayed,et al.  Preparation and Growth Mechanism of Gold Nanorods (NRs) Using Seed-Mediated Growth Method , 2003 .

[77]  Peter B. Yim,et al.  Probing the dynamic fluorescence properties of single water-soluble quantum dots , 2008 .

[78]  Song Jin,et al.  Hyperbranched PbS and PbSe nanowires and the effect of hydrogen gas on their synthesis. , 2007, Nano letters.

[79]  E. Bakkers,et al.  Synthesis of InP nanotubes. , 2003, Journal of the American Chemical Society.

[80]  M. Bawendi,et al.  Synthesis and characterization of nearly monodisperse CdE (E = sulfur, selenium, tellurium) semiconductor nanocrystallites , 1993 .

[81]  U. Banin,et al.  Synthesis and Properties of CdSe/ZnS Core/Shell Nanorods , 2003 .

[82]  S. Kawakami,et al.  Mannosylated semiconductor quantum dots for the labeling of macrophages. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[83]  E. Coronado,et al.  The Optical Properties of Metal Nanoparticles: The Influence of Size, Shape, and Dielectric Environment , 2003 .

[84]  Weiwei Guo,et al.  Glutathione-mediated release of functional plasmid DNA from positively charged quantum dots. , 2008, Biomaterials.

[85]  William W. Yu,et al.  Biological interactions of quantum dot nanoparticles in skin and in human epidermal keratinocytes. , 2008, Toxicology and applied pharmacology.

[86]  Alexander Wei,et al.  Uniform gold nanorod arrays from polyethylenimine-coated alumina templates. , 2005, The journal of physical chemistry. B.

[87]  S. Nie,et al.  In vivo cancer targeting and imaging with semiconductor quantum dots , 2004, Nature Biotechnology.

[88]  Yong Ding,et al.  Catalyst-nanostructure interfacial lattice mismatch in determining the shape of VLS grown nanowires and nanobelts: a case of Sn/ZnO. , 2004, Journal of the American Chemical Society.

[89]  Tymish Y. Ohulchanskyy,et al.  Structure-activity relationship among purpurinimides and bacteriopurpurinimides: trifluoromethyl substituent enhanced the photosensitizing efficacy. , 2007, Journal of medicinal chemistry.

[90]  Uwe H F Bunz,et al.  Preferential end-to-end assembly of gold nanorods by biotin-streptavidin connectors. , 2003, Journal of the American Chemical Society.

[91]  Catherine J. Murphy,et al.  Fine-tuning the shape of gold nanorods , 2005 .

[92]  Warren C. W. Chan,et al.  Quantum Dots in Biological and Biomedical Research: Recent Progress and Present Challenges , 2006 .

[93]  Xiaohua Huang,et al.  Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods. , 2006, Journal of the American Chemical Society.

[94]  Zhiqiang Gao,et al.  Silicon nanowire arrays for label-free detection of DNA. , 2007, Analytical chemistry.

[95]  Christine A Iacobuzio-Donahue,et al.  Claudin 4 protein expression in primary and metastatic pancreatic cancer: support for use as a therapeutic target. , 2004, American journal of clinical pathology.

[96]  M. Swihart,et al.  Growth of CdSe Quantum Rods and Multipods Seeded by Noble‐Metal Nanoparticles , 2006 .

[97]  Jun‐Jie Zhu,et al.  A Novel Method for the Preparation of Lead Selenide: Pulse Sonoelectrochemical Synthesis of Lead Selenide Nanoparticles , 2000 .

[98]  Dansheng Song,et al.  Protein microarrays and quantum dot probes for early cancer detection. , 2007, Colloids and surfaces. B, Biointerfaces.

[99]  Xiaogang Peng,et al.  Formation of high-quality CdTe, CdSe, and CdS nanocrystals using CdO as precursor. , 2001, Journal of the American Chemical Society.

[100]  Tristan Barrett,et al.  Simultaneous multicolor imaging of five different lymphatic basins using quantum dots. , 2007, Nano letters.

[101]  Mark T Swihart,et al.  Organically capped silicon nanoparticles with blue photoluminescence prepared by hydrosilylation followed by oxidation. , 2006, Langmuir : the ACS journal of surfaces and colloids.

[102]  Steven C Kazmierczak,et al.  From diagnostics to therapy: prospects of quantum dots. , 2007, Clinical biochemistry.

[103]  K. Hull,et al.  Induced Branching in Confined PbSe Nanowires , 2005 .

[104]  E. Stachowiak,et al.  Organically modified silica nanoparticles: a nonviral vector for in vivo gene delivery and expression in the brain. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[105]  Hao Ming Chen,et al.  Controlling the length and shape of gold nanorods. , 2005, The journal of physical chemistry. B.

[106]  Jerry S. H. Lee,et al.  Magnetic nanoparticles in MR imaging and drug delivery. , 2008, Advanced drug delivery reviews.

[107]  M. Swihart,et al.  Multiplex Imaging of Pancreatic Cancer Cells by Using Functionalized Quantum Rods , 2008 .

[108]  R. Hruban,et al.  Precursors to pancreatic cancer. , 2007, Gastroenterology clinics of North America.

[109]  F. Wang,et al.  The inhibition of osteogenesis with human bone marrow mesenchymal stem cells by CdSe/ZnS quantum dot labels. , 2006, Biomaterials.

[110]  James R. Johnson,et al.  Quantum dot probes for bacteria distinguish Escherichia coli mutants and permit in vivo imaging. , 2008, Chemical communications.

[111]  Microwave synthesis of highly aligned ultra narrow semiconductor rods and wires. , 2006 .

[112]  Paras N Prasad,et al.  Folate-receptor-mediated delivery of InP quantum dots for bioimaging using confocal and two-photon microscopy. , 2005, Journal of the American Chemical Society.

[113]  M. El-Sayed,et al.  Chemistry and properties of nanocrystals of different shapes. , 2005, Chemical reviews.

[114]  Sang Cheon Lee,et al.  Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection. , 2008, Biomaterials.

[115]  A Paul Alivisatos,et al.  Discrete nanostructures of quantum dots/Au with DNA. , 2004, Journal of the American Chemical Society.

[116]  U. Banin,et al.  Synthesis of hybrid CdS-Au colloidal nanostructures. , 2006, The journal of physical chemistry. B.

[117]  Charles M Lieber,et al.  Synthesis of CdS and ZnS nanowires using single-source molecular precursors. , 2003, Journal of the American Chemical Society.

[118]  Kemin Wang,et al.  Immunofluorescent labeling of cancer cells with quantum dots synthesized in aqueous solution. , 2006, Analytical biochemistry.

[119]  A. Göpferich,et al.  Polymer coating of quantum dots--a powerful tool toward diagnostics and sensorics. , 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[120]  Catherine J. Murphy,et al.  Wet Chemical Synthesis of High Aspect Ratio Cylindrical Gold Nanorods , 2001 .

[121]  Timothy Thatt Yang Tan,et al.  Size control, shape evolution, and silica coating of near-infrared-emitting PbSe quantum dots , 2007 .

[122]  P. Prasad,et al.  Formation of ZnTe Nanowires by Oriented Attachment , 2007 .

[123]  Sanjiv S Gambhir,et al.  Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects. , 2006, Nano letters.

[124]  Dong-Hwang Chen,et al.  Formation and characterization of Au–Ag bimetallic nanoparticles in water-in-oil microemulsions , 2002 .

[125]  J. Jang,et al.  Solvothermal Synthesis of CdS Nanowires for Photocatalytic Hydrogen and Electricity Production , 2007 .

[126]  Vincent Noireaux,et al.  In Vivo Imaging of Quantum Dots Encapsulated in Phospholipid Micelles , 2002, Science.

[127]  Jennifer A Hollingsworth,et al.  Pushing the band gap envelope: mid-infrared emitting colloidal PbSe quantum dots. , 2004, Journal of the American Chemical Society.

[128]  Hong Ding,et al.  Gold Nanorods Coated with Multilayer Polyelectrolyte as Contrast Agents for Multimodal Imaging , 2007 .

[129]  Peidong Yang,et al.  Interfacing silicon nanowires with mammalian cells. , 2007, Journal of the American Chemical Society.

[130]  Hong Ding,et al.  Optically and Magnetically Doped Organically Modified Silica Nanoparticles as Efficient Magnetically Guided Biomarkers for Two-Photon Imaging of Live Cancer Cells† , 2008 .

[131]  M. Bawendi,et al.  Renal clearance of quantum dots , 2007, Nature Biotechnology.

[132]  Shuming Nie,et al.  Quantum dots: emerging applications in urologic oncology. , 2008, Urologic oncology.

[133]  A Paul Alivisatos,et al.  Room-temperature single-nucleotide polymorphism and multiallele DNA detection using fluorescent nanocrystals and microarrays. , 2003, Analytical chemistry.

[134]  Xiaogang Peng,et al.  Epitaxial Growth of Highly Luminescent CdSe/CdS Core/Shell Nanocrystals with Photostability and Electronic Accessibility , 1997 .

[135]  D. Zhao,et al.  Controlled Synthesis of Semiconductor PbS Nanocrystals and Nanowires Inside Mesoporous Silica SBA-15 Phase , 2001 .

[136]  Shimon Weiss,et al.  Synthesis and Properties of Biocompatible Water-Soluble Silica-Coated CdSe/ZnS Semiconductor Quantum Dots† , 2001 .

[137]  M. Breunig,et al.  Quantum dots - nano-sized probes for the exploration of cellular and intracellular targeting. , 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[138]  R. Langer,et al.  Intracellular delivery of core-shell fluorescent silica nanoparticles. , 2008, Biomaterials.

[139]  Yong Zhang,et al.  Upconversion fluorescence imaging of cells and small animals using lanthanide doped nanocrystals. , 2008, Biomaterials.

[140]  Glenn P. Goodrich,et al.  Scattering Spectra of Single Gold Nanoshells , 2004 .

[141]  I. Chen,et al.  The surface modification of silver nanoparticles by phosphoryl disulfides for improved biocompatibility and intracellular uptake. , 2008, Biomaterials.

[142]  K. Jain.  Nanoparticles as targeting ligands. , 2006, Trends in biotechnology.

[143]  Erkki Ruoslahti,et al.  Nanocrystal targeting in vivo , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[144]  Eli Ruckenstein,et al.  Luminescent Silicon Nanoparticles Capped by Conductive Polyaniline through the Self-Assembly Method , 2004 .

[145]  J. Cameron,et al.  Analysis of novel tumor markers in pancreatic and biliary carcinomas using tissue microarrays. , 2004, Human pathology.

[146]  Charles M. Lieber,et al.  A laser ablation method for the synthesis of crystalline semiconductor nanowires , 1998, Science.

[147]  Xiaohua Huang,et al.  Peptide-conjugated gold nanorods for nuclear targeting. , 2007, Bioconjugate chemistry.

[148]  Joseph Kost,et al.  Switchable assembly of ultra narrow CdS nanowires and nanorods. , 2006, Journal of the American Chemical Society.

[149]  S. Kanwal,et al.  Synthesis of aqueous CdTe quantum dots embedded silica nanoparticles and their applications as fluorescence probes. , 2009, Talanta: The International Journal of Pure and Applied Analytical Chemistry.

[150]  J. Zai,et al.  Synthesis of 3-D Hierarchical Dendrites of Lead Chalcogenides in Large Scale via Microwave-Assistant Method , 2007 .

[151]  Paul H. Holloway,et al.  GdIII‐Functionalized Fluorescent Quantum Dots as Multimodal Imaging Probes , 2006 .

[152]  Jie Pan,et al.  Targeting and imaging cancer cells by folate-decorated, quantum dots (QDs)- loaded nanoparticles of biodegradable polymers. , 2009, Biomaterials.

[153]  J. West,et al.  Immunotargeted nanoshells for integrated cancer imaging and therapy. , 2005, Nano letters.

[154]  P. Prasad,et al.  Control of the morphology and size of PbS nanowires using gold nanoparticles , 2006 .

[155]  S. Nie,et al.  Quantum dot bioconjugates for ultrasensitive nonisotopic detection. , 1998, Science.

[156]  Guanghui Yu,et al.  Quantum dot-mediated detection of gamma-aminobutyric acid binding sites on the surface of living pollen protoplasts in tobacco. , 2006, Chemistry & biology.

[157]  Feng Zhao,et al.  Bio-distribution and metabolic paths of silica coated CdSeS quantum dots. , 2008, Toxicology and applied pharmacology.

[158]  Chao Li,et al.  Complementary detection of prostate-specific antigen using In2O3 nanowires and carbon nanotubes. , 2005, Journal of the American Chemical Society.

[159]  Yadong Yin,et al.  Colloidal nanocrystal synthesis and the organic–inorganic interface , 2005, Nature.

[160]  Ken-Tye Yong,et al.  Biocompatible luminescent silicon quantum dots for imaging of cancer cells. , 2008, ACS nano.

[161]  Scott C. Brown,et al.  Nanoparticles for bioimaging. , 2006, Advances in colloid and interface science.

[162]  Y. Huh,et al.  Nanomedical imaging: In vivo imaging with smart nanohybrid , 2006 .

[163]  Kemin Wang,et al.  Dye-doped nanoparticles for bioanalysis , 2007 .

[164]  B. Korgel,et al.  Nucleation and growth of germanium nanowires seeded by organic monolayer-coated gold nanocrystals. , 2002, Journal of the American Chemical Society.

[165]  M. Bawendi,et al.  (CdSe)ZnS Core-Shell Quantum Dots - Synthesis and Characterization of a Size Series of Highly Luminescent Nanocrystallites , 1997 .

[166]  D. Balding,et al.  HLA Sequence Polymorphism and the Origin of Humans , 2006 .

[167]  Robert Sinclair,et al.  Improved QD-BRET conjugates for detection and imaging. , 2008, Biochemical and biophysical research communications.

[168]  Paras N Prasad,et al.  Organically modified silica nanoparticles co-encapsulating photosensitizing drug and aggregation-enhanced two-photon absorbing fluorescent dye aggregates for two-photon photodynamic therapy. , 2007, Journal of the American Chemical Society.

[169]  C. Mirkin,et al.  Thermal desorption behavior and binding properties of DNA bases and nucleosides on gold. , 2002, Journal of the American Chemical Society.

[170]  Jasmina Lovrić,et al.  Fate of micelles and quantum dots in cells. , 2007, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.