Complex regulatory mechanisms mediated by the interplay of multiple post-translational modifications.
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[1] Alma L. Burlingame,et al. Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin , 2017, Nature.
[2] H. Chan,et al. An allosteric conduit facilitates dynamic multisite substrate recognition by the SCFCdc4 ubiquitin ligase , 2017, Nature Communications.
[3] J. Forman-Kay,et al. Liquid-liquid phase separation in cellular signaling systems. , 2016, Current opinion in structural biology.
[4] Ronald D. Vale,et al. Phase separation of signaling molecules promotes T cell receptor signal transduction , 2016, Science.
[5] A. Kanagaraj,et al. Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization , 2015, Cell.
[6] C. Brangwynne,et al. The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics , 2015, Proceedings of the National Academy of Sciences.
[7] A. V. Zaytsev,et al. Multisite phosphorylation of the NDC80 complex gradually tunes its microtubule-binding affinity , 2015, Molecular biology of the cell.
[8] Timothy D. Craggs,et al. Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles , 2015, Molecular cell.
[9] Rui Jiang,et al. Systematic Characterization and Prediction of Post-Translational Modification Cross-Talk* , 2015, Molecular & Cellular Proteomics.
[10] L. Kay,et al. Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch , 2014, Nature.
[11] E. Betzig,et al. Author response: Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans , 2014 .
[12] P. Wright,et al. Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation , 2014, Proceedings of the National Academy of Sciences.
[13] J. Ferrell,et al. Ultrasensitivity part II: multisite phosphorylation, stoichiometric inhibitors, and positive feedback. , 2014, Trends in biochemical sciences.
[14] Sudeep Banjade,et al. Phase transitions of multivalent proteins can promote clustering of membrane receptors , 2014, eLife.
[15] J. Mellor,et al. Lysine Acetylation Controls Local Protein Conformation by Influencing Proline Isomerization , 2014, Molecular cell.
[16] Jennifer M. Bui,et al. Phosphorylation of an intrinsically disordered segment in Ets1 shifts conformational sampling toward binding-competent substates. , 2014, Structure.
[17] Predrag Radivojac,et al. The structural and functional signatures of proteins that undergo multiple events of post‐translational modification , 2014, Protein science : a publication of the Protein Society.
[18] L. McIntosh,et al. Synergy of aromatic residues and phosphoserines within the intrinsically disordered DNA-binding inhibitory elements of the Ets-1 transcription factor , 2014, Proceedings of the National Academy of Sciences.
[19] I. Aifantis,et al. “ Ubiquitylation : mechanism and functions ” Review series Regulation of stem cell function by protein ubiquitylation , 2014 .
[20] P. Bork,et al. Evolution and functional cross‐talk of protein post‐translational modifications , 2013, Molecular systems biology.
[21] S. Bicciato,et al. Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast , 2013, EMBO molecular medicine.
[22] N. Sonenberg,et al. Interaction of the eukaryotic initiation factor 4E with 4E-BP2 at a dynamic bipartite interface. , 2013, Structure.
[23] Ailan Guo,et al. Immunoaffinity Enrichment and Mass Spectrometry Analysis of Protein Methylation , 2013, Molecular & Cellular Proteomics.
[24] S. Reed,et al. Ubiquitin ligases and cell cycle control. , 2013, Annual review of biochemistry.
[25] Xing Li,et al. A method for systematic mapping of protein lysine methylation identifies functions for HP1β in DNA damage response. , 2013, Molecular cell.
[26] Matthew P Torres,et al. Deciphering post‐translational modification codes , 2013, FEBS letters.
[27] Ulrich Stelzl,et al. Dual Coordination of Post Translational Modifications in Human Protein Networks , 2013, PLoS Comput. Biol..
[28] A Keith Dunker,et al. The alphabet of intrinsic disorder , 2013, Intrinsically disordered proteins.
[29] A. Yamaguchi,et al. The Effect of PRMT1-Mediated Arginine Methylation on the Subcellular Localization, Stress Granules, and Detergent-Insoluble Aggregates of FUS/TLS , 2012, PloS one.
[30] R. Nussinov,et al. Allosteric post-translational modification codes. , 2012, Trends in biochemical sciences.
[31] W. Lim,et al. Systematic Functional Prioritization of Protein Posttranslational Modifications , 2012, Cell.
[32] M. Tyers,et al. Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase , 2012, Proceedings of the National Academy of Sciences.
[33] I. Landrieu,et al. Structural characterization by nuclear magnetic resonance of the impact of phosphorylation in the proline‐rich region of the disordered Tau protein , 2012, Proteins.
[34] Paul S. Russo,et al. Phase Transitions in the Assembly of MultiValent Signaling Proteins , 2016 .
[35] M. Stallcup,et al. Functional interplay between p53 acetylation and H1.2 phosphorylation in p53-regulated transcription , 2011, Oncogene.
[36] Stefani N. Thomas,et al. Dual modification of Alzheimer’s disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach , 2011, Acta Neuropathologica.
[37] Y. Liou,et al. Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins. , 2011, Trends in biochemical sciences.
[38] T. Höfer,et al. Circadian conformational change of the Neurospora clock protein FREQUENCY triggered by clustered hyperphosphorylation of a basic domain. , 2011, Molecular cell.
[39] L. Sistonen,et al. Regulation of HSF1 function in the heat stress response: implications in aging and disease. , 2011, Annual review of biochemistry.
[40] G. Hart,et al. Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease. , 2011, Annual review of biochemistry.
[41] G. Manfioletti,et al. Conformational role for the C-terminal tail of the intrinsically disordered high mobility group A (HMGA) chromatin factors. , 2011, Journal of proteome research.
[42] Hidenori Akutsu,et al. A Distinct Role for Pin1 in the Induction and Maintenance of Pluripotency* , 2011, The Journal of Biological Chemistry.
[43] Ikuko Nishikawa,et al. Computational Prediction of O-linked Glycosylation Sites That Preferentially Map on Intrinsically Disordered Regions of Extracellular Proteins , 2010, International journal of molecular sciences.
[44] Peter E. Wright,et al. Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation , 2010, Proceedings of the National Academy of Sciences.
[45] G. Guy,et al. Additional Serine/Threonine Phosphorylation Reduces Binding Affinity but Preserves Interface Topography of Substrate Proteins to the c-Cbl TKB Domain , 2010, PloS one.
[46] G. Hart,et al. O-GlcNAc Transferase Regulates Mitotic Chromatin Dynamics* , 2010, The Journal of Biological Chemistry.
[47] T. Pawson,et al. Post-translational modifications in signal integration , 2010, Nature Structural &Molecular Biology.
[48] J. Shabanowitz,et al. Extensive Crosstalk Between O-GlcNAcylation and Phosphorylation Regulates Cytokinesis , 2010, Science Signaling.
[49] M. Mann,et al. Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions , 2009, Science.
[50] B. Benayoun,et al. A post-translational modification code for transcription factors: sorting through a sea of signals. , 2009, Trends in cell biology.
[51] Mike Tyers,et al. Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor , 2008, Proceedings of the National Academy of Sciences.
[52] G. Hart,et al. Cross-talk between GlcNAcylation and phosphorylation: Site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc , 2008, Proceedings of the National Academy of Sciences.
[53] John A Latham,et al. Cross-regulation of histone modifications , 2007, Nature Structural &Molecular Biology.
[54] Xiao Zhen Zhou,et al. The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease , 2007, Nature Reviews Molecular Cell Biology.
[55] A. Pandey,et al. Dynamic Interplay between O-Linked N-Acetylglucosaminylation and Glycogen Synthase Kinase-3-dependent Phosphorylation* , 2007, Molecular & Cellular Proteomics.
[56] H. Chan,et al. Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity , 2007, Proceedings of the National Academy of Sciences.
[57] Gerald W. Hart,et al. Cycling of O-linked β-N-acetylglucosamine on nucleocytoplasmic proteins , 2007, Nature.
[58] Pier Paolo Pandolfi,et al. The mechanisms of PML-nuclear body formation. , 2006, Molecular cell.
[59] S. Berger,et al. Repression of p53 activity by Smyd2-mediated methylation , 2006, Nature.
[60] W. Yang,et al. Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability , 2006, Nature Cell Biology.
[61] Christopher J. Nelson,et al. Proline Isomerization of Histone H3 Regulates Lysine Methylation and Gene Expression , 2006, Cell.
[62] V. Giguère,et al. Control of MEF2 Transcriptional Activity by Coordinated Phosphorylation and Sumoylation* , 2006, Journal of Biological Chemistry.
[63] Sylvie Garneau-Tsodikova,et al. Protein posttranslational modifications: the chemistry of proteome diversifications. , 2005, Angewandte Chemie.
[64] G. Hart,et al. Perturbations in O-linked β-N-Acetylglucosamine Protein Modification Cause Severe Defects in Mitotic Progression and Cytokinesis* , 2005, Journal of Biological Chemistry.
[65] L. Kay,et al. Variable Control of Ets-1 DNA Binding by Multiple Phosphates in an Unstructured Region , 2005, Science.
[66] R. Mantovani,et al. Pin1 links the activities of c-Abl and p300 in regulating p73 function. , 2004, Molecular cell.
[67] Joseph R. Nevins,et al. A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells , 2004, Nature Cell Biology.
[68] W. Gu,et al. Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[69] O. Jensen. Modification-specific proteomics: characterization of post-translational modifications by mass spectrometry. , 2004, Current opinion in chemical biology.
[70] L. Iakoucheva,et al. The importance of intrinsic disorder for protein phosphorylation. , 2004, Nucleic acids research.
[71] R. Blumenthal,et al. Many paths to methyltransfer: a chronicle of convergence. , 2003, Trends in biochemical sciences.
[72] Thomas Höfer,et al. Allosteric regulation of the transcription factor NFAT1 by multiple phosphorylation sites: a mathematical analysis. , 2003, Journal of molecular biology.
[73] Mark Johnston,et al. Methylation of Histone H3 by COMPASS Requires Ubiquitination of Histone H2B by Rad6* , 2002, The Journal of Biological Chemistry.
[74] Matthias Mann,et al. Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway. , 2002, Genes & development.
[75] Y. Liou,et al. Pinning down proline-directed phosphorylation signaling. , 2002, Trends in cell biology.
[76] Hengbin Wang,et al. Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase. , 2001, Molecular cell.
[77] Tony Pawson,et al. Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication , 2001, Nature.
[78] P. Cohen,et al. GSK3 takes centre stage more than 20 years after its discovery. , 2001, The Biochemical journal.
[79] R. Morimoto,et al. Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1 , 2001, The EMBO journal.
[80] Tianhua Niu,et al. Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c‐Jun towards cyclin D1 , 2001, The EMBO journal.
[81] Gerald W. Hart,et al. Glycosylation of Nucleocytoplasmic Proteins: Signal Transduction and O-GlcNAc , 2001, Science.
[82] Brian D. Strahl,et al. Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly , 2001, Science.
[83] G Fischer,et al. Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins. , 2000, Molecular cell.
[84] J. Qin,et al. Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity. , 2000, Molecular cell.
[85] C. Ponting,et al. Regulation of chromatin structure by site-specific histone H3 methyltransferases , 2000, Nature.
[86] C. Allis,et al. The language of covalent histone modifications , 2000, Nature.
[87] A. Wolffe,et al. Chromatin disruption and modification. , 1999, Nucleic acids research.
[88] U. Reimer,et al. Role of phosphorylation in determining the backbone dynamics of the serine/threonine-proline motif and Pin1 substrate recognition. , 1998, Biochemistry.
[89] D. Lane,et al. Small peptides activate the latent sequence-specific DNA binding function of p53 , 1995, Cell.
[90] G. Hart,et al. Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins. , 2007, Nature.
[91] A. Dejean,et al. Conjugation with the ubiquitin‐related modifier SUMO‐1 regulates the partitioning of PML within the nucleus , 1998, The EMBO journal.
[92] A. Otte. Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines , 1997 .
[93] K MURRAY,et al. THE OCCURRENCE OF EPSILON-N-METHYL LYSINE IN HISTONES. , 1964, Biochemistry.
[94] K. Murray,et al. The Occurrence of iε-N-Methyl Lysine in Histones , 1964 .