A comparison of iopamidol and metrizamide for cervical myelography in the dog.

Cervical myelography using iopamidol, a new nonionic contrast medium, was studied in nine dogs. Postmyelographic seizure activity, motor evoked potentials, and rectal temperatures were monitored, and myelographic quality was subjectively evaluated. The results were compared with data from eight dogs that had metrizamide myelography. The iopamidol group had fewer seizures (p < 0.01) but exhibited no difference in motor evoked potential or rectal temperature recordings. Myelographic quality was similar for iopamidol and metrizamide. The study suggests that iopamidol was less neurotoxic than metrizamide for canine cervical myelography.

[1]  S. Ekholm,et al.  Iopamidol and neural tissue metabolism. A comparative in vitro study. , 1986, Investigative radiology.

[2]  M. Walker,et al.  Prevention of postmetrizamide myelographic seizures in dogs, using 5% dextrose solution. , 1986, Journal of the American Veterinary Medical Association.

[3]  F. H. Cox,et al.  The use of iopamidol for myelography in dogs: a study of twenty-seven cases , 1986 .

[4]  G. Johnson,et al.  Transient leakage across the blood-cerebrospinal fluid barrier after intrathecal metrizamide administration to dogs. , 1985, American journal of veterinary research.

[5]  S. Wheeler,et al.  Iohexol myelography in the dog and cat: a series of one hundred cases, and a comparison with metrizamide and iopamidol , 1985 .

[6]  S. Ekholm,et al.  Neurotoxicity of metrizamide. , 1985, Archives of neurology.

[7]  P. Turski,et al.  Clinical Comparison of Metrizamide and Iopamidol for Myelography , 1984 .

[8]  A. Sudilovsky,et al.  Overview of U.S. Clinical Experience on Intrathecal Application of Iopamidol , 1984 .

[9]  E. Felder.  Chemistry of Iopamidol , 1984 .

[10]  B. Drayer,et al.  Comparative Safety of Intrathecal lopamidol vs. Metrizamide for Myelography and Cisternography , 1984 .

[11]  R. Bryan,et al.  Neuronal effects of water-soluble contrast agents. , 1984, Investigative radiology.

[12]  W. J. Hamilton,et al.  Irreversible neurologic complications of metrizamide myelography , 1984, Neurology.

[13]  R. Bryan,et al.  Neurotoxic effects of water-soluble contrast agents on rat hippocampus. , 1984, Investigative radiology.

[14]  R. Conrad.  METRIZAMIDE MYELOGRAPHY OF THE EQUINE CERVICAL SPINE , 1984 .

[15]  S. Ekholm,et al.  The effect of iohexol on glucose metabolism compared with metrizamide. , 1983, Investigative radiology.

[16]  L. Hayman,et al.  Concentration of intrathecal 3H-labeled metrizamide in normal dog brain: age-related differences. , 1983, AJNR. American journal of neuroradiology.

[17]  S. Ekholm,et al.  Metrizamide--a potential in vivo inhibitor of glucose metabolism. , 1983, Radiology.

[18]  I. Kricheff,et al.  Comparison of radiographic quality and adverse reactions in myelography with iopamidol and metrizamide. , 1983, AJNR. American journal of neuroradiology.

[19]  E. Marder,et al.  Cholinergic actions of metrizamide. , 1983, AJNR. American journal of neuroradiology.

[20]  J. Kaude,et al.  Neurotoxicologic effects of the nonionic contrast agent iopamidol on the leptomeninges of the dog. , 1982, American journal of veterinary research.

[21]  R. Bryan,et al.  Neurotoxicity of iohexol: a new nonionic contrast medium. , 1982, Radiology.

[22]  J. Bertoni,et al.  Competitive inhibition of brain hexokinase by metrizamide , 1982, Neurology.

[23]  J. M. Creighton,et al.  Ioglucomide: a new nonionic myelographic agent. Preclinical studies. , 1981, Radiology.

[24]  W. Adams,et al.  COMPLICATIONS OF METRIZAMIDE MYELOGRAPHY IN THE DOG: A SUMMARY OF 107 CLINICAL CASE HISTORIES , 1981 .

[25]  R. Pool,et al.  Metrizamide myelography in the horse: clinical, radiographic, and pathologic changes. , 1980, American journal of veterinary research.

[26]  Stowater Jl,et al.  Clinical evaluation of metrizamide as a myelographic agent in the dog. , 1979 .

[27]  J. Beech.  Metrizamide Myelography in the Horse1 , 1979 .

[28]  J. E. Bartels,et al.  An Experimental Evaluation of a Non‐ionic Agent Amipaque (Metrizamide) as a Neuroradiologic Medium in the Dog , 1977 .

[29]  S. Gilman,et al.  Effect of isotonic contrast agents on spinal reflexes in the cat. , 1977, Radiology.

[30]  S. Olsson,et al.  Myelography with Metrizamide in the Dog: A Clinical Study on Its Use for the Demonstration of Spinal Cord Lesions other Than Those Caused by Intervertebral Disk Protrusions1 , 1976 .

[31]  T. Hindmarsh.  Myelography with the Non-Ionic Water-Soluble Contrast Medium Metrizamide , 1975, Acta radiologica: diagnosis.