Epidural abscess caused by Haemophilus aphrophilus misidentified as Pasteurella species.

Haemophilus aphrophilus is one of the normal oropharyngeal flora and rarely implicated as a pathogen of spinal infection. A case of H. aphrophilus bacteremia complicated with epidural abscess, psoas muscle abscess, and spondylodiscitis is described in this report. The pathogen was mis-identified as Pasteurella spp. at the very start, and was confirmed by the molecular method. He was successfully treated with adequate antibiotics and surgery. The clinical features of sixteen previously reported cases of spinal infection caused by H. aphrophilus are reviewed.

[1]  W. Ko,et al.  Clinical characteristics of invasive Haemophilus aphrophilus infections. , 2005, Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.

[2]  T. Popović-Uroić,et al.  Vertebral osteomyelitis caused byHaemophilus aphrophilus , 1993, European Journal of Clinical Microbiology and Infectious Diseases.

[3]  K. Yuen,et al.  Anaerobic, non-sporulating, Gram-positive bacilli bacteraemia characterized by 16S rRNA gene sequencing. , 2004, Journal of medical microbiology.

[4]  P. Denoel,et al.  Assessment of the Nasopharyngeal Bacterial Flora of Rhesus Macaques: Moraxella, Neisseria, Haemophilus, and Other Genera , 2002, Journal of Clinical Microbiology.

[5]  A. Poullis,et al.  It could only happen to a doctor—Haemophilus aphrophilus septicaemia complicated by a prevertebral infection after dental work , 2001, Postgraduate medical journal.

[6]  W Frederiksen,et al.  Possible misidentification of Haemophilus aphrophilus as Pasteurella gallinarum. , 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[7]  B. La Scola,et al.  Vertebral infections caused by Haemophilus aphrophilus: case report and review. , 2001, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[8]  Robertson De.  Femoral osteomyelitis after tooth extraction. , 1998 .

[9]  D. E. Roberts.  Femoral osteomyelitis after tooth extraction. , 1998, American journal of orthopedics.

[10]  C. Hung,et al.  Haemophilus aphrophilus bacteraemia complicated with vertebral osteomyelitis and spinal epidural abscess in a patient with liver cirrhosis. , 1997, The Journal of infection.

[11]  A. Lennon,et al.  Rapid identification of Actinobacillus actinomycetemcomitans, Haemophilus aphrophilus, and Haemophilus paraphrophilus by restriction enzyme analysis of PCR-amplified 16S rRNA genes , 1997, Journal of clinical microbiology.

[12]  D. Margelli,et al.  [Haemophilus aphrophilus as a rare cause of bacterial spondylitis]. , 1996, Swiss medical weekly.

[13]  A. Bisno,et al.  Antibiotic treatment of adults with infective endocarditis due to streptococci, enterococci, staphylococci, and HACEK microorganisms. American Heart Association. , 1995, JAMA.

[14]  R. George,et al.  Haemophilus aphrophilus discitis and vertebral osteomyelitis. , 1995, Scandinavian journal of infectious diseases.

[15]  X. Chevalier,et al.  Vacuum sign in spondylodiscitis due to H aphrophilus. , 1993, Annals of the Rheumatic Diseases.

[16]  J. Sánchez-Román,et al.  Idiopathic orbital myositis: treatment with cyclosporin. , 1993, Annals of the rheumatic diseases.

[17]  S. Dawson,et al.  Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. , 1992, The Journal of infection.

[18]  F. Dewhirst,et al.  Phylogeny of 54 representative strains of species in the family Pasteurellaceae as determined by comparison of 16S rRNA sequences , 1992, Journal of bacteriology.

[19]  L. Jani,et al.  [Bacterial spondylitis caused by Haemophilus aphrophilus]. , 1991, Immunität und Infektion.

[20]  E. Stephanian,et al.  Intervertebral disc space infection and osteomyelitis due to Hemophilus species: report of two cases and review. , 1989, Journal of spinal disorders.

[21]  M. Weinstein,et al.  Vertebral osteomyelitis due to Haemophilus aphrophilus: treatment with ceftriaxone. , 1989, The Journal of infectious diseases.

[22]  M. Gribble,et al.  Hemophilus aphrophilus vertebral osteomyelitis: a case report and literature review. , 1987, Diagnostic microbiology and infectious disease.

[23]  V. Labombardi,et al.  Controlled, comparative study of ciprofloxacin versus ampicillin in treatment of bacterial respiratory tract infections. , 1987, The American journal of medicine.

[24]  F. Houssiau,et al.  Haemophilus aphrophilus: a rare pathogen in vertebral osteomyelitis. , 1987, Annals of the rheumatic diseases.

[25]  R. Danner,et al.  Update on spinal epidural abscess: 35 cases and review of the literature. , 1987, Reviews of infectious diseases.

[26]  R. Robinson,et al.  Hemophilus aphrophilus meningitis followed by vertebral osteomyelitis and suppurative psoas abscess. , 1985, The American journal of medicine.

[27]  L. Wolff,et al.  Distribution of oral Haemophilus species in dental plaque from a large adult population , 1984, Infection and immunity.

[28]  D. Snydman,et al.  Hemophilus aphrophilus osteomyelitis. , 1984, The American journal of medicine.

[29]  S. Eykyn,et al.  Vertebral osteomyelitis due to coccobacilli of the HB group. , 1983, British medical journal.

[30]  L. Edwards,et al.  Hemophilus aphrophilus endocarditis with a probable primary dental focus of infection. , 1981, Chest.

[31]  Bieger Rc,et al.  Haemophilus aphrophilus : A microbiologic and clinical review and report of 42 cases , 1978 .

[32]  J. Washington,et al.  HAEMOPHILUS APHROPHILUS: A MICROBIOLOGIC AND CLINICAL REVIEW AND REPORT OF 42 CASES , 1978, Medicine.

[33]  Ellen Jo Baron,et al.  Manual of clinical microbiology , 1975 .

[34]  B. Meyers,et al.  Hemophilus aphrophilus endocarditis: review of 23 cases. , 1975, American Journal of Cardiology.

[35]  K. Zinnemann,et al.  The Growth Requirements Of Haemophilus Aphrophilus , 1969 .

[36]  M I Page,et al.  Infection due to Actinobacillus actinomycetemcomitans and Haemophilus aphrophilus. , 1966, The New England journal of medicine.

[37]  O. Khairat.  Endocarditis due to a new species of Hæmophilus , 1940 .