Three or more routes for leukocyte migration into the central nervous system

[1]  P PamelaSwain,et al.  A new view , 2004 .

[2]  W. Fierz,et al.  T cell approach to demyelinating diseases , 2004, Springer Seminars in Immunopathology.

[3]  R. Ransohoff,et al.  Human cerebrospinal fluid central memory CD4+ T cells: Evidence for trafficking through choroid plexus and meninges via P-selectin , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[4]  David H. Miller,et al.  A controlled trial of natalizumab for relapsing multiple sclerosis. , 2003, The New England journal of medicine.

[5]  Christophe Longépé.  The participants and their roles , 2003 .

[6]  L. Boon,et al.  Transfer of Central Nervous System Autoantigens and Presentation in Secondary Lymphoid Organs1 , 2002, The Journal of Immunology.

[7]  Rena Li,et al.  Microglia and inflammatory mechanisms in the clearance of amyloid β peptide , 2002 .

[8]  G. Garden.  Microglia in human immunodeficiency virus‐associated neurodegeneration , 2002, Glia.

[9]  R. Veerhuis,et al.  Neuroinflammation in Alzheimer's disease and prion disease , 2002, Glia.

[10]  A. Cardona,et al.  γ/δ T Cell-Deficient Mice Exhibit Reduced Disease Severity and Decreased Inflammatory Response in the Brain in Murine Neurocysticercosis , 2002, The Journal of Immunology.

[11]  K. Frei,et al.  Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation. , 2002, The Journal of infectious diseases.

[12]  R. Rudick,et al.  T‐cells in the cerebrospinal fluid express a similar repertoire of inflammatory chemokine receptors in the absence or presence of CNS inflammation: implications for CNS trafficking , 2002, Clinical and experimental immunology.

[13]  C. Janeway,et al.  Role of genetic background in P selectin-dependent immune surveillance of the central nervous system , 2002, Journal of Neuroimmunology.

[14]  S. Jander,et al.  Dendritic cells and dendritic-like microglia in focal cortical ischemia of the mouse brain , 2002, Journal of Neuroimmunology.

[15]  P. Kubes,et al.  Overlapping Roles of P-Selectin and α4 Integrin to Recruit Leukocytes to the Central Nervous System in Experimental Autoimmune Encephalomyelitis1 , 2002, The Journal of Immunology.

[16]  L. Massacesi.  Compartmentalization of the immune response in the central nervous system and natural history of multiple sclerosis. Implications for therapy , 2002, Clinical Neurology and Neurosurgery.

[17]  P. Stevenson,et al.  Uncoupling of virus-induced inflammation and anti-viral immunity in the brain parenchyma. , 2002, The Journal of general virology.

[18]  R. Ransohoff,et al.  Monocyte recruitment and myelin removal are delayed following spinal cord injury in mice with CCR2 chemokine receptor deletion , 2002, Journal of neuroscience research.

[19]  K. Matsushima,et al.  Neutralization of IFN‐inducible protein 10/CXCL10 exacerbates experimental autoimmune encephalomyelitis , 2002, European journal of immunology.

[20]  H. Neumann,et al.  Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases , 2002, Trends in Neurosciences.

[21]  Kouji Matsushima,et al.  Pivotal Role of Dendritic Cell–derived CXCL10 in the Retention of T Helper Cell 1 Lymphocytes in Secondary Lymph Nodes , 2002, The Journal of experimental medicine.

[22]  M. Weller,et al.  A Functional Role of HLA-G Expression in Human Gliomas: An Alternative Strategy of Immune Escape1 , 2002, The Journal of Immunology.

[23]  Eugene C. Butcher,et al.  Molecular Mechanisms Involved in Lymphocyte Recruitment in Inflamed Brain Microvessels: Critical Roles for P-Selectin Glycoprotein Ligand-1 and Heterotrimeric Gi-Linked Receptors1 , 2002, The Journal of Immunology.

[24]  G. Gores,et al.  Mechanisms of hepatotoxicity. , 2002, Toxicological sciences : an official journal of the Society of Toxicology.

[25]  B. Engelhardt,et al.  Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice. , 2002, The Journal of clinical investigation.

[26]  T. Smirnova,et al.  Recruitment of dendritic cells to the cerebrospinal fluid in bacterial neuroinfections , 2002, Journal of Neuroimmunology.

[27]  J. Cyster,et al.  CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity. , 2002, Immunity.

[28]  C. Brosnan,et al.  γδ T Cells Express Activation Markers in the Central Nervous System of Mice with Chronic-relapsing Experimental Autoimmune Encephalomyelitis , 2001 .

[29]  R. Egleton,et al.  Molecular physiology and pathophysiology of tight junctions in the blood–brain barrier , 2001, Trends in Neurosciences.

[30]  B. Rollins.  Chemokines and atherosclerosis: what Adam Smith has to say about vascular disease. , 2001, The Journal of clinical investigation.

[31]  Steffen Jung,et al.  The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium. , 2001, The Journal of clinical investigation.

[32]  J. Goverman,et al.  A Pathogenic Role for Myelin-Specific Cd8+ T Cells in a Model for Multiple Sclerosis , 2001, The Journal of experimental medicine.

[33]  B. Engelhardt,et al.  Alpha4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels. , 2001, The Journal of clinical investigation.

[34]  A. Falus,et al.  Inhibition of Antigen‐Specific T Cell Trafficking into the Central Nervous System via Blocking PECAM1/CD31 Molecule , 2001, Journal of neuropathology and experimental neurology.

[35]  S. Kunkel,et al.  EncephalomyelitisDuring Experimental Autoimmune Accumulation in the Central Nervous System T Cell + Control of Encephalitogenic CD4 -Inducible Protein-10) g CXCL10 (IFN-and , 2001 .

[36]  James J. Campbell,et al.  Unique Subpopulations of CD56+ NK and NK-T Peripheral Blood Lymphocytes Identified by Chemokine Receptor Expression Repertoire1 , 2001, The Journal of Immunology.

[37]  H. Lassmann,et al.  Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis. , 2001, Immunity.

[38]  V. Kuchroo,et al.  Discordant effects of anti-VLA-4 treatment before and after onset of relapsing experimental autoimmune encephalomyelitis. , 2001, The Journal of clinical investigation.

[39]  W. Hickey,et al.  CXC Chemokine Receptor-2 Ligands Are Required for Neutrophil-Mediated Host Defense in Experimental Brain Abscesses1 , 2001, The Journal of Immunology.

[40]  B. Rollins,et al.  Absence of Monocyte Chemoattractant Protein 1 in Mice Leads to Decreased Local Macrophage Recruitment and Antigen-Specific T Helper Cell Type 1 Immune Response in Experimental Autoimmune Encephalomyelitis , 2001, The Journal of experimental medicine.

[41]  C. Janeway,et al.  CD62L is required on effector cells for local interactions in the CNS to cause myelin damage in experimental allergic encephalomyelitis. , 2001, Immunity.

[42]  V. Kostulas,et al.  Two subsets of dendritic cells are present in human cerebrospinal fluid. , 2001, Brain : a journal of neurology.

[43]  J. Cyster,et al.  Chemokines as regulators of T cell differentiation , 2001, Nature Immunology.

[44]  M B Segal,et al.  Transport of nutrients across the choroid plexus , 2001, Microscopy research and technique.

[45]  P. Kubes,et al.  A Role for Platelets and Endothelial Selectins in Tumor Necrosis Factor-&agr;–Induced Leukocyte Recruitment in the Brain Microvasculature , 2000, Circulation research.

[46]  G. Krissansen,et al.  Prevention of a chronic progressive form of experimental autoimmune encephalomyelitis by an antibody against mucosal addressin cell adhesion molecule‐1, given early in the course of disease progression , 2000, Immunology and cell biology.

[47]  B. Serafini,et al.  Intracerebral recruitment and maturation of dendritic cells in the onset and progression of experimental autoimmune encephalomyelitis. , 2000, The American journal of pathology.

[48]  H. Weiner,et al.  Resistance to Experimental Autoimmune Encephalomyelitis in Mice Lacking the Cc Chemokine Receptor (Ccr2) , 2000, The Journal of experimental medicine.

[49]  J. Goverman,et al.  In Situ Tolerance within the Central Nervous System as a Mechanism for Preventing Autoimmunity , 2000, The Journal of experimental medicine.

[50]  W. Kuziel,et al.  Cc Chemokine Receptor 2 Is Critical for Induction of Experimental Autoimmune Encephalomyelitis , 2000, The Journal of experimental medicine.

[51]  Hans Lassmann,et al.  Clonal Expansions of Cd8+ T Cells Dominate the T Cell Infiltrate in Active Multiple Sclerosis Lesions as Shown by Micromanipulation and Single Cell Polymerase Chain Reaction , 2000, The Journal of experimental medicine.

[52]  H. Weiner,et al.  Leukocyte recruitment during onset of experimental allergic encephalomyelitis is CCR1 dependent , 2000, European journal of immunology.

[53]  W. Hickey,et al.  Proinflammatory cytokine, chemokine, and cellular adhesion molecule expression during the acute phase of experimental brain abscess development. , 2000, The American journal of pathology.

[54]  J. Ghersi-Egea,et al.  Choroid Plexus in the Central Nervous System: Biology and Physiopathology , 2000, Journal of neuropathology and experimental neurology.

[55]  C. Janeway,et al.  Differential adhesion molecule requirements for immune surveillance and inflammatory recruitment. , 2000, Brain : a journal of neurology.

[56]  E. Butcher,et al.  Chemokines in tissue-specific and microenvironment-specific lymphocyte homing. , 2000, Current opinion in immunology.

[57]  G. Reichmann,et al.  Phenotype and Functions of Brain Dendritic Cells Emerging During Chronic Infection of Mice with Toxoplasma gondii1 , 2000, The Journal of Immunology.

[58]  W. Kuziel,et al.  Induction of experimental autoimmune encephalomyelitis in C57BL / 6 mice deficient in either the chemokine macrophage inflammatory protein‐1α or its CCR5 receptor , 2000, European journal of immunology.

[59]  E. Leung,et al.  β7 integrins contribute to demyelinating disease of the central nervous system , 2000, Journal of Neuroimmunology.

[60]  G. Nuki,et al.  CD44 is involved in selective leucocyte extravasation during inflammatory central nervous system disease , 1999, Immunology.

[61]  Jacqueline Palace,et al.  The effect of anti-α4 integrin antibody on brain lesion activity in MS , 1999, Neurology.

[62]  I. Weissman,et al.  Antibodies to CD44 and integrin alpha4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[63]  W. Hickey,et al.  Leukocyte traffic in the central nervous system: the participants and their roles. , 1999, Seminars in immunology.

[64]  P. McMenamin,et al.  Distribution and phenotype of dendritic cells and resident tissue macrophages in the dura mater, leptomeninges, and choroid plexus of the rat brain as demonstrated in wholemount preparations , 1999, The Journal of comparative neurology.

[65]  M. Boulton,et al.  Contribution of extracranial lymphatics and arachnoid villi to the clearance of a CSF tracer in the rat. , 1999, American journal of physiology. Regulatory, integrative and comparative physiology.

[66]  A. Cardona,et al.  Development of an Animal Model for Neurocysticercosis: Immune Response in the Central Nervous System Is Characterized by a Predominance of γδ T Cells , 1999, The Journal of Immunology.

[67]  E. Butcher,et al.  L-selectin–mediated Leukocyte Adhesion In Vivo: Microvillous Distribution Determines Tethering Efficiency, But Not Rolling Velocity , 1999, The Journal of experimental medicine.

[68]  B. Engelhardt,et al.  The development of experimental autoimmune encephalomyelitis in the mouse requires alpha4-integrin but not alpha4beta7-integrin. , 1998, The Journal of clinical investigation.

[69]  Y. Chen,et al.  Experimental autoimmune encephalomyelitis in intercellular adhesion molecule-1-deficient mice. , 1998, Cellular immunology.

[70]  P. Loetscher,et al.  Lymphocyte‐specific chemokine receptor CXCR3: regulation, chemokine binding and gene localization , 1998, European journal of immunology.

[71]  R. Weller.  Pathology of Cerebrospinal Fluid and Interstitial Fluid of the CNS: Significance for Alzheimer Disease, Prion Disorders and Multiple Sclerosis , 1998, Journal of neuropathology and experimental neurology.

[72]  Christoph Schaniel,et al.  Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation , 1998, European journal of immunology.

[73]  M. Pfaff,et al.  Integrin affinity modulation. , 1998, Trends in cell biology.

[74]  V. Perry,et al.  CXC chemokines generate age-related increases in neutrophil-mediated brain inflammation and blood–brain barrier breakdown , 1998, Current Biology.

[75]  W. Hickey,et al.  Antigen-dependent intrathecal antibody synthesis in the normal rat brain: tissue entry and local retention of antigen-specific B cells. , 1998, Journal of immunology.

[76]  C. Mackay,et al.  Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes , 1998, The Journal of experimental medicine.

[77]  K C Lin,et al.  Very late antigen 4 (VLA4) antagonists as anti-inflammatory agents. , 1998, Current opinion in chemical biology.

[78]  B. Engelhardt,et al.  E- and P-selectin are not involved in the recruitment of inflammatory cells across the blood-brain barrier in experimental autoimmune encephalomyelitis. , 1997, Blood.

[79]  James J. Campbell,et al.  Multistep Navigation and the Combinatorial Control of Leukocyte Chemotaxis , 1997, The Journal of cell biology.

[80]  S. Karlik,et al.  Evidence for a prolonged role of alpha sub 4 integrin throughout active experimental allergic encephalomyelitis , 1996, Neurology.

[81]  V. Perry,et al.  Recombinant Human Adenovirus with Rat MIP‐2 Gene Insertion Causes Prolonged PMN Recruitment to the Murine Brain , 1996, The European journal of neuroscience.

[82]  V. Perry,et al.  The potential role of dendritic cells in immune-mediated inflammatory diseases in the central nervous system , 1996, Neuroscience.

[83]  B. Trapp,et al.  Neutrophil infiltration, glial reaction, and neurological disease in transgenic mice expressing the chemokine N51/KC in oligodendrocytes. , 1996, The Journal of clinical investigation.

[84]  B. Engelhardt,et al.  Lymphocyte Targeting of the Central Nervous System: A Review of Afferent and Efferent CNS‐Immune Pathways , 1996, Brain pathology.

[85]  T. Mayadas,et al.  Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins. , 1996, The Journal of clinical investigation.

[86]  M. Edsbagge,et al.  Lymphocyte phenotype and subset distribution in normal cerebrospinal fluid , 1995, Journal of Neuroimmunology.

[87]  R. Strieter,et al.  An important role for the chemokine macrophage inflammatory protein-1 alpha in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis. , 1995, Journal of immunology.

[88]  Y. Ron,et al.  Bothanti-CD11a(LFA-l) and anti-CD11b (MAC-1) therapy delay the onset and diminish the severity of experimental autoimmune encephalomyelitis , 1995, Journal of Neuroimmunology.

[89]  V. Perry,et al.  Inflammation in the nervous system , 1995, Current Opinion in Neurobiology.

[90]  E. Butcher,et al.  A central role for microvillous receptor presentation in leukocyte adhesion under flow , 1995, Cell.

[91]  M. Miyasaka,et al.  Antibodies against leukocyte function-associated antigen-1 and against intercellular adhesion molecule-1 together suppress the progression of experimental allergic encephalomyelitis. , 1995, Cellular immunology.

[92]  S. Karlik,et al.  A monoclonal antibody to α4 integrin suppresses and reverses active experimental allergic encephalomyelitis , 1995, Journal of Neuroimmunology.

[93]  E. Berg,et al.  α4 integrins mediate lymphocyte attachment and rolling under physiologic flow , 1995, Cell.

[94]  C. Polman,et al.  Analysis of CD27 surface expression on T cell subsets in MS patients and control individuals , 1995, Journal of Neuroimmunology.

[95]  Y. Ron,et al.  Both anti-CD11a (LFA-1) and anti-CD11b (MAC-1) therapy delay the onset and diminish the severity of experimental autoimmune encephalomyelitis. , 1995, Journal of neuroimmunology.

[96]  M. Schwartz,et al.  Integrins: emerging paradigms of signal transduction. , 1995, Annual review of cell and developmental biology.

[97]  J. Olschowka,et al.  Expression of ICAM-1, VCAM-1, L-selectin, and leukosialin in the mouse central nervous system during the induction and remission stages of experimental allergic encephalomyelitis , 1994, Journal of Neuroimmunology.

[98]  B. Engelhardt,et al.  Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse. , 1994, The American journal of pathology.

[99]  B. Trapp,et al.  Detection of MHC class II-antigens on macrophages and microglia, but not on astrocytes and endothelia in active multiple sclerosis lesions , 1994, Journal of Neuroimmunology.

[100]  T. Springer.  Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm , 1994, Cell.

[101]  V. Kuchroo,et al.  Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis. , 1993, Journal of immunology.

[102]  G. Hansson,et al.  Adhesion molecule expression on cerebrospinal fluid T lymphocytes: Evidence for common recruitment mechanisms in multiple sclerosis, aseptic meningitis, and normal controls , 1993, Annals of neurology.

[103]  H. Hartung,et al.  Inhibition of experimental autoimmune encephalomyelitis by an antibody to the intercellular adhesion molecule ICAM‐1 , 1993, Annals of neurology.

[104]  Changhee Kim,et al.  Homing of T cells to the central nervous system throughout the course of relapsing experimental autoimmune encephalomyelitis in Thy-1 congenic mice , 1993, Journal of Neuroimmunology.

[105]  A. Cross,et al.  Anti-adhesion molecule therapy in experimental autoimmune encephalomyelitis , 1993, Journal of Neuroimmunology.

[106]  M. Miyasaka,et al.  ICAM-1-dependent pathway is not critically involved in the inflammatory process of autoimmune encephalomyelitis or in cytokine-induced inflammation of the central nervous system , 1993, Journal of Neuroimmunology.

[107]  J. Rose,et al.  Augmentation of adoptively transferred experimental allergic encephalomyelitis by administration of a monoclonal antibody specific for LFA-1α , 1993, Journal of Neuroimmunology.

[108]  H. Lassmann,et al.  Bone marrow derived elements and resident microglia in brain inflammation , 1993, Glia.

[109]  C. Janeway,et al.  Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma , 1993, The Journal of experimental medicine.

[110]  V. Perry,et al.  The inflammatory response in the CNS , 1992, Neuropathology and applied neurobiology.

[111]  R O Weller,et al.  Pathways of Fluid Drainage from the Brain ‐ Morphological Aspects and Immunological Significance in Rat and Man , 1992, Brain pathology.

[112]  T. Owens,et al.  Direct demonstration of the infiltration of murine central nervous system by Pgp-1/CD44high CD45RBlow CD4+ T cells that induce experimental allergic encephalomyelitis , 1992, Journal of Neuroimmunology.

[113]  F. Sánchez‐Madrid,et al.  Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin , 1992, Nature.

[114]  P. Knopf,et al.  Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view. , 1992, Immunology today.

[115]  W. Hickey.  Migration of Hematogenous Cells Through the Blood‐Brain Barrier and the Initiation of CNS Inflammation , 1991, Brain pathology.

[116]  B. Uitdehaag,et al.  Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages , 1990, The Journal of experimental medicine.

[117]  Sunhee C. Lee,et al.  Multiple Sclerosis: A Role for Astroglia in Active Demyelination Suggested by Class II MHC Expression and Ultrastructural Study , 1990, Journal of neuropathology and experimental neurology.

[118]  B. Johansson,et al.  Immune Response in Deep Cervical Lymph Nodes and Spleen in the Mouse after Antigen Deposition in Different Intracerebral Sites , 1988, Scandinavian journal of immunology.

[119]  W. Hickey,et al.  Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. , 1988, Science.

[120]  W. Griffin,et al.  Functional capacity of solid tissue transplants in the brain: evidence for immunological privilege , 1985, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[121]  D. Linthicum,et al.  Acute experimental autoimmune encephalomyelitis in mice. I. Adjuvant action of Bordetella pertussis is due to vasoactive amine sensitization and increased vascular permeability of the central nervous system. , 1982, Cellular immunology.

[122]  C. Brosnan,et al.  The effects of macrophage depletion on the clinical and pathologic expression of experimental allergic encephalomyelitis. , 1981, Journal of immunology.