Revisiting the Arthritogenic Peptide Theory: Quantitative Not Qualitative Changes in the Peptide Repertoire of HLA–B27 Allotypes

The association of HLA–B27 with spondyloarthropathy is one of the strongest documented for any autoimmune disease. A common hypothesis for this association is the arthritogenic peptide concept. This dictates that differences in the peptide binding preferences of disease‐associated and non–disease‐associated HLA–B27 allotypes underlie the presentation of bacterial and self‐peptides, leading to cross‐reactive T cell immunity and subsequent autoimmune attack of affected tissues. The aim of this study was to analyze and compare self‐peptides from 8 HLA–B27 allotypes, to increase existing data sets of HLA–B27 ligands, to refine and compare their consensus‐binding motifs, and to reveal similarities and differences in the peptide repertoire of the HLA–B27 subtypes.

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