Nucleocytoplasmic trafficking and transcription effects of huntingtin in Huntington's disease
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[1] Michael P. Cusack,et al. Huntingtin Phosphorylation Sites Mapped by Mass Spectrometry , 2006, Journal of Biological Chemistry.
[2] K. Shinoda,et al. Huntingtin-associated protein 1 (HAP1) interacts with androgen receptor (AR) and suppresses SBMA-mutant-AR-induced apoptosis. , 2006, Human molecular genetics.
[3] U. Stelzl,et al. Huntingtin interacts with the receptor sorting family protein GASP2 , 2006, Journal of Neural Transmission.
[4] T. Ebner,et al. Bidirectional expression of CUG and CAG expansion transcripts and intranuclear polyglutamine inclusions in spinocerebellar ataxia type 8 , 2006, Nature Genetics.
[5] S. Hersch,et al. Sp1 Is Up-regulated in Cellular and Transgenic Models of Huntington Disease, and Its Reduction Is Neuroprotective* , 2006, Journal of Biological Chemistry.
[6] T. Cooper,et al. RNA-mediated neuromuscular disorders. , 2006, Annual review of neuroscience.
[7] L. Raymond,et al. Cleavage at the Caspase-6 Site Is Required for Neuronal Dysfunction and Degeneration Due to Mutant Huntingtin , 2006, Cell.
[8] K. Jones,et al. Wnt signaling: is the party in the nucleus? , 2006, Genes & development.
[9] Lu Gan,et al. Palmitoylation of huntingtin by HIP14is essential for its trafficking and function , 2006, Nature Neuroscience.
[10] M. MacDonald,et al. Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease , 2006, Neurobiology of Disease.
[11] In-Hyun Park,et al. A Nuclear Transport Signal in Mammalian Target of Rapamycin Is Critical for Its Cytoplasmic Signaling to S6 Kinase 1* , 2006, Journal of Biological Chemistry.
[12] R. Berges,et al. Effect of a new leuprorelin formulation on testosterone levels in patients with advanced prostate cancer , 2006, Current medical research and opinion.
[13] A. Shevchenko,et al. Huntingtin–HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease , 2006, The Journal of cell biology.
[14] L. Ellerby,et al. Ataxin-7 Can Export from the Nucleus via a Conserved Exportin-dependent Signal* , 2006, Journal of Biological Chemistry.
[15] Walter Birchmeier,et al. Balancing cell adhesion and Wnt signaling, the key role of β-catenin , 2006 .
[16] E. Wanker,et al. Interaction of huntingtin fragments with brain membranes – clues to early dysfunction in Huntington's disease , 2006, Journal of neurochemistry.
[17] J. Sutcliffe,et al. Selective deficits in the expression of striatal‐enriched mRNAs in Huntington's disease , 2006, Journal of neurochemistry.
[18] A. Levine,et al. p53 tumor suppressor protein regulates the levels of huntingtin gene expression , 2006, Oncogene.
[19] J. Mallet,et al. Lentiviral‐mediated gene transfer of brain‐derived neurotrophic factor is neuroprotective in a mouse model of neonatal excitotoxic challenge , 2006, Journal of neuroscience research.
[20] C. Chiang,et al. The General Transcription Machinery and General Cofactors , 2006, Critical reviews in biochemistry and molecular biology.
[21] R. Snell,et al. TATA-binding protein in neurodegenerative disease , 2005, Neuroscience.
[22] Elena Cattaneo,et al. Normal huntingtin function: an alternative approach to Huntington's disease , 2005, Nature Reviews Neuroscience.
[23] Emmanuel Brouillet,et al. Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment , 2005, Neurobiology of Disease.
[24] W. H. Goldmann,et al. Huntingtin Associates with Acidic Phospholipids at the Plasma Membrane* , 2005, Journal of Biological Chemistry.
[25] S. Cregan,et al. Inhibition of Metabotropic Glutamate Receptor Signaling by the Huntingtin-binding Protein Optineurin* , 2005, Journal of Biological Chemistry.
[26] A. El-Husseini,et al. Modulation of neuronal protein trafficking and function by palmitoylation , 2005, Current Opinion in Neurobiology.
[27] M. Chesselet,et al. Early behavioral deficits in R6/2 mice suitable for use in preclinical drug testing , 2005, Neurobiology of Disease.
[28] Elena Cattaneo,et al. Progressive loss of BDNF in a mouse model of Huntington's disease and rescue by BDNF delivery. , 2005, Pharmacological research.
[29] I. Mills,et al. Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors , 2005, The Journal of cell biology.
[30] S. Snyder,et al. p53 Mediates Cellular Dysfunction and Behavioral Abnormalities in Huntington’s Disease , 2005, Neuron.
[31] B. Chait,et al. Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[32] Yoshiyuki Matsuura,et al. Structural basis for nuclear import complex dissociation by RanGTP , 2005, Nature.
[33] A. Aguilera. Cotranscriptional mRNP assembly: from the DNA to the nuclear pore. , 2005, Current opinion in cell biology.
[34] Harry T Orr,et al. A cell-based screen for modulators of ataxin-1 phosphorylation. , 2005, Human molecular genetics.
[35] R. Margolis,et al. Huntington's disease like-2: review and update. , 2005, Acta neurologica Taiwanica.
[36] Holger Wesche,et al. High throughput screening for protein kinase inhibitors. , 2005, Combinatorial chemistry & high throughput screening.
[37] Fumiaki Tanaka,et al. Widespread nuclear and cytoplasmic accumulation of mutant androgen receptor in SBMA patients. , 2005, Brain : a journal of neurology.
[38] A. Young,et al. A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[39] M. MacDonald,et al. Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation , 2005, BMC Neuroscience.
[40] Harry T Orr,et al. RNA association and nucleocytoplasmic shuttling by ataxin-1 , 2005, Journal of Cell Science.
[41] A. Hopkins,et al. Navigating chemical space for biology and medicine , 2004, Nature.
[42] U. Moens,et al. What turns CREB on? , 2004, Cellular signalling.
[43] Harry T Orr,et al. Recovery from Polyglutamine-Induced Neurodegeneration in Conditional SCA1 Transgenic Mice , 2004, The Journal of Neuroscience.
[44] M. Fainzilber,et al. Integration of Retrograde Axonal and Nuclear Transport Mechanisms in Neurons: Implications for Therapeutics , 2004, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.
[45] Ilya Bezprozvanny,et al. Deranged neuronal calcium signaling and Huntington disease. , 2004, Biochemical and biophysical research communications.
[46] C. Dargemont,et al. Nuclear export of RNA , 2004, Biology of the cell.
[47] H. Lehrach,et al. A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. , 2004, Molecular cell.
[48] P. Patterson,et al. Activation of the IκB Kinase Complex and Nuclear Factor-κB Contributes to Mutant Huntingtin Neurotoxicity , 2004, The Journal of Neuroscience.
[49] D. Borchelt,et al. Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice. , 2004, Human molecular genetics.
[50] Fabrice P Cordelières,et al. Huntingtin Controls Neurotrophic Support and Survival of Neurons by Enhancing BDNF Vesicular Transport along Microtubules , 2004, Cell.
[51] M. Hayden,et al. Inhibition of Calpain Cleavage of Huntingtin Reduces Toxicity , 2004, Journal of Biological Chemistry.
[52] Thorsten Schmidt,et al. Autosomal dominant cerebellar ataxias: clinical features, genetics, and pathogenesis , 2004, The Lancet Neurology.
[53] J. Littleton,et al. Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[54] Fumiaki Tanaka,et al. Spinal and bulbar muscular atrophy: ligand-dependent pathogenesis and therapeutic perspectives , 2004, Journal of Molecular Medicine.
[55] Christine Klein,et al. Focal dystonia as a presenting sign of spinocerebellar ataxia 17 , 2004, Movement disorders : official journal of the Movement Disorder Society.
[56] M. Hayden,et al. Huntingtin Bodies Sequester Vesicle-Associated Proteins by a Polyproline-Dependent Interaction , 2004, The Journal of Neuroscience.
[57] John D. Aitchison,et al. Cell Cycle Regulated Transport Controlled by Alterations in the Nuclear Pore Complex , 2003, Cell.
[58] M. Koltzenburg,et al. Axoplasmic Importins Enable Retrograde Injury Signaling in Lesioned Nerve , 2003, Neuron.
[59] P. Giannakakou,et al. The importance of p53 location: nuclear or cytoplasmic zip code? , 2003, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.
[60] V. Bolivar,et al. Exploratory activity and fear conditioning abnormalities develop early in R6/2 Huntington's disease transgenic mice. , 2003, Behavioral neuroscience.
[61] Leslie Michels Thompson,et al. A Rapid Cellular FRET Assay of Polyglutamine Aggregation Identifies a Novel Inhibitor , 2003, Neuron.
[62] G. Sobue. [Development of therapeutics for spinal and bulbar muscular atrophy (SBMA)]. , 2003, Rinsho shinkeigaku = Clinical neurology.
[63] Qiuheng Zhang,et al. Identification and Characterization of a Ligand-regulated Nuclear Export Signal in Androgen Receptor* , 2003, Journal of Biological Chemistry.
[64] Martin Drozda,et al. Depletion of wild‐type huntingtin in mouse models of neurologic diseases , 2003, Journal of neurochemistry.
[65] J. Roh,et al. Huntingtin is degraded to small fragments by calpain after ischemic injury☆ , 2003, Experimental Neurology.
[66] Andrea Crotti,et al. Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes , 2003, Nature Genetics.
[67] P. Chaudhary,et al. Use of adeno-associated viral vector for delivery of small interfering RNA , 2003, Oncogene.
[68] R. Truant,et al. Huntingtin contains a highly conserved nuclear export signal. , 2003, Human molecular genetics.
[69] Deborah L. Johnson,et al. The TATA-Binding Protein as a Regulator of Cellular Transformation , 2003, Cell cycle.
[70] Effat S. Emamian,et al. Serine 776 of Ataxin-1 Is Critical for Polyglutamine-Induced Disease in SCA1 Transgenic Mice , 2003, Neuron.
[71] L. Farrell,et al. Mutant huntingtin increases nuclear corepressor function and enhances ligand-dependent nuclear hormone receptor activation , 2003, Molecular and Cellular Neuroscience.
[72] M. Hayden,et al. Nuclear Localization of a Non-caspase Truncation Product of Atrophin-1, with an Expanded Polyglutamine Repeat, Increases Cellular Toxicity* , 2003, The Journal of Biological Chemistry.
[73] T. Littlewood,et al. GLFG and FxFG Nucleoporins Bind to Overlapping Sites on Importin-β* , 2002, The Journal of Biological Chemistry.
[74] S. Hersch,et al. HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis. , 2002, Human molecular genetics.
[75] J. Gusella,et al. The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor , 2002, BMC Neuroscience.
[76] Richard I. Morimoto,et al. Polyglutamine protein aggregates are dynamic , 2002, Nature Cell Biology.
[77] M. Mancini,et al. Intranuclear ataxin1 inclusions contain both fast- and slow-exchanging components , 2002, Nature Cell Biology.
[78] G. Sobue,et al. Testosterone Reduction Prevents Phenotypic Expression in a Transgenic Mouse Model of Spinal and Bulbar Muscular Atrophy , 2002, Neuron.
[79] J. Olson,et al. Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects. , 2002, Human molecular genetics.
[80] J. Olson,et al. Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease. , 2002, Human molecular genetics.
[81] M. Hetzer,et al. The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly , 2002, Nature Cell Biology.
[82] H. Paulson,et al. Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[83] D. Görlich,et al. The permeability barrier of nuclear pore complexes appears to operate via hydrophobic exclusion , 2002, The EMBO journal.
[84] K. Wilson,et al. The nuclear envelope, lamins and nuclear assembly. , 2002, Current opinion in cell biology.
[85] M. Hayden,et al. Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior. , 2002, Human molecular genetics.
[86] J. Alberch,et al. Neuroprotection by neurotrophins and GDNF family members in the excitotoxic model of Huntington’s disease , 2002, Brain Research Bulletin.
[87] D. Housman,et al. A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila , 2002, Nature Genetics.
[88] J. Nevins,et al. Huntingtin Is Present in the Nucleus, Interacts with the Transcriptional Corepressor C-terminal Binding Protein, and Represses Transcription* , 2002, The Journal of Biological Chemistry.
[89] P. Silver,et al. Protein and RNA export from the nucleus. , 2002, Developmental cell.
[90] B. Henderson,et al. ARM Domain-dependent Nuclear Import of Adenomatous Polyposis Coli Protein Is Stimulated by the B56α Subunit of Protein Phosphatase 2A* , 2001, The Journal of Biological Chemistry.
[91] I. Macara. Transport into and out of the Nucleus , 2001, Microbiology and Molecular Biology Reviews.
[92] A. Silkov,et al. A Composite Nuclear Export Signal in the TBP-associated Factor TAFII105* , 2001, The Journal of Biological Chemistry.
[93] J. Darnell,et al. Microarray Identification of FMRP-Associated Brain mRNAs and Altered mRNA Translational Profiles in Fragile X Syndrome , 2001, Cell.
[94] B. Majello,et al. Control of RNA polymerase II activity by dedicated CTD kinases and phosphatases. , 2001, Frontiers in bioscience : a journal and virtual library.
[95] P. Marynen,et al. NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation , 2001, Current Biology.
[96] P. Reddy,et al. Polyglutamine-expanded Huntingtin Promotes Sensitization of N-Methyl-d-aspartate Receptors via Post-synaptic Density 95* , 2001, The Journal of Biological Chemistry.
[97] Blair R. Leavitt,et al. Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease , 2001, Science.
[98] T. Littlewood,et al. Molecular mechanism of translocation through nuclear pore complexes during nuclear protein import , 2001, FEBS letters.
[99] T. Wada,et al. The regulation of elongation by eukaryotic RNA polymerase II: a recent view. , 2001, Molecules and cells.
[100] P Bork,et al. Comparison of ARM and HEAT protein repeats. , 2001, Journal of molecular biology.
[101] William I. Weis,et al. The Structure of the β-Catenin/E-Cadherin Complex and the Molecular Basis of Diverse Ligand Recognition by β-Catenin , 2001, Cell.
[102] D. Rigamonti,et al. Huntingtin's Neuroprotective Activity Occurs via Inhibition of Procaspase-9 Processing* , 2001, The Journal of Biological Chemistry.
[103] H. Lehrach,et al. Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation. , 2001, Molecular biology of the cell.
[104] F. Gage,et al. Identities of Sequestered Proteins in Aggregates from Cells with Induced Polyglutamine Expression , 2001, The Journal of cell biology.
[105] C A Ross,et al. Interference by Huntingtin and Atrophin-1 with CBP-Mediated Transcription Leading to Cellular Toxicity , 2001, Science.
[106] K Ribbeck,et al. Kinetic analysis of translocation through nuclear pore complexes , 2001, The EMBO journal.
[107] C. Ross,et al. Isolation of a 40-kDa Huntingtin-associated Protein* , 2001, The Journal of Biological Chemistry.
[108] J. Hodgson,et al. Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo. , 2001, American journal of human genetics.
[109] M. MacDonald,et al. Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles. , 2000, Human molecular genetics.
[110] B. Cullen,et al. Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[111] K. Arahata,et al. Nuclear envelope proteins and associated diseases , 2000, Current opinion in neurology.
[112] B. Henderson. Nuclear-cytoplasmic shuttling of APC regulates β-catenin subcellular localization and turnover , 2000, Nature Cell Biology.
[113] M. MacDonald,et al. Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis. , 2000, Human molecular genetics.
[114] Mariann Bienz,et al. The APC tumour suppressor has a nuclear export function , 2000, Nature.
[115] D. Housman,et al. The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[116] S. Wente. Gatekeepers of the nucleus. , 2000, Science.
[117] S. Pulst,et al. A novel protein with RNA-binding motifs interacts with ataxin-2. , 2000, Human molecular genetics.
[118] A. Hackam,et al. Wild-Type Huntingtin Protects from Apoptosis Upstream of Caspase-3 , 2000, The Journal of Neuroscience.
[119] H. Zoghbi,et al. Fourteen and counting: unraveling trinucleotide repeat diseases. , 2000, Human molecular genetics.
[120] René Hen,et al. Reversal of Neuropathology and Motor Dysfunction in a Conditional Model of Huntington's Disease , 2000, Cell.
[121] B. Chait,et al. The Yeast Nuclear Pore Complex: Composition, Architecture, and Transport Mechanism , 2000 .
[122] D. Andrews,et al. Identification of the Endoplasmic Reticulum Targeting Signal in Vesicle-associated Membrane Proteins* , 1999, The Journal of Biological Chemistry.
[123] T. Hope,et al. An N‐terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IκBα , 1999 .
[124] B. Rayet,et al. Aberrant rel/nfkb genes and activity in human cancer , 1999, Oncogene.
[125] B. Cullen,et al. The Human Tap Nuclear RNA Export Factor Contains a Novel Transportin-dependent Nuclear Localization Signal That Lacks Nuclear Export Signal Function* , 1999, The Journal of Biological Chemistry.
[126] M. Azumano,et al. Nuclear localization of transcription factor Sp1. , 1999, Nucleic acids symposium series.
[127] M. MacDonald,et al. Mutant Huntingtin Forms in Vivo Complexes with Distinct Context-Dependent Conformations of the Polyglutamine Segment , 1999, Neurobiology of Disease.
[128] G. Suske. The Sp-family of transcription factors. , 1999, Gene.
[129] J. M. Boutell,et al. Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin. , 1999, Human molecular genetics.
[130] D. Borchelt,et al. Nuclear Accumulation of Truncated Atrophin-1 Fragments in a Transgenic Mouse Model of DRPLA , 1999, Neuron.
[131] M. Nachury,et al. The direction of transport through the nuclear pore can be inverted. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[132] C. Ross,et al. Nuclear Targeting of Mutant Huntingtin Increases Toxicity , 1999, Molecular and Cellular Neuroscience.
[133] D. Housman,et al. Evidence for a recruitment and sequestration mechanism in Huntington's disease. , 1999, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.
[134] Jones Al. The localization and interactions of huntingtin , 1999 .
[135] Claire-Anne Gutekunst,et al. A YAC Mouse Model for Huntington’s Disease with Full-Length Mutant Huntingtin, Cytoplasmic Toxicity, and Selective Striatal Neurodegeneration , 1999, Neuron.
[136] R. Myers,et al. Impaired synaptic plasticity in mice carrying the Huntington's disease mutation. , 1999, Human molecular genetics.
[137] G. Wahl,et al. A leucine‐rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking , 1999, The EMBO journal.
[138] R. Truant,et al. Nuclear Import of Cdk/Cyclin Complexes: Identification of Distinct Mechanisms for Import of Cdk2/Cyclin E and Cdc2/Cyclin B1 , 1999, The Journal of cell biology.
[139] K. Moulder,et al. Generation of Neuronal Intranuclear Inclusions by Polyglutamine-GFP: Analysis of Inclusion Clearance and Toxicity as a Function of Polyglutamine Length , 1999, The Journal of Neuroscience.
[140] L. Poellinger,et al. Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of theCBP/p300 coactivator by the hypoxia‐induciblefactor‐1α , 1998, The EMBO journal.
[141] Harry T Orr,et al. Ataxin-1 Nuclear Localization and Aggregation Role in Polyglutamine-Induced Disease in SCA1 Transgenic Mice , 1998, Cell.
[142] Steven Finkbeiner,et al. Huntingtin Acts in the Nucleus to Induce Apoptosis but Death Does Not Correlate with the Formation of Intranuclear Inclusions , 1998, Cell.
[143] M. MacDonald,et al. Huntingtin interacts with a family of WW domain proteins. , 1998, Human molecular genetics.
[144] G. Stein,et al. Interrelationships of nuclear structure and transcriptional control: Functional consequences of being in the right place at the right time , 1998, Journal of cellular biochemistry.
[145] M. Yanagida,et al. Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. , 1998, Experimental cell research.
[146] M. MacDonald,et al. Huntingtin: a single bait hooks many species , 1998, Current Opinion in Neurobiology.
[147] G. Blobel,et al. Transport routes through the nuclear pore complex. , 1998, Current opinion in cell biology.
[148] M. Rout,et al. Karyopherins and kissing cousins. , 1998, Trends in cell biology.
[149] C. Ross,et al. HAP1‐huntingtin interactions do not contribute to the molecular pathology in Huntington's disease transgenic mice , 1998, FEBS letters.
[150] Dale E. Bredesen,et al. Caspase Cleavage of Gene Products Associated with Triplet Expansion Disorders Generates Truncated Fragments Containing the Polyglutamine Tract* , 1998, The Journal of Biological Chemistry.
[151] B. Cullen,et al. Identification and Functional Characterization of a Novel Nuclear Localization Signal Present in the Yeast Nab2 Poly(A)+ RNA Binding Protein , 1998, Molecular and Cellular Biology.
[152] R. Albin,et al. Ectopically Expressed CAG Repeats Cause Intranuclear Inclusions and a Progressive Late Onset Neurological Phenotype in the Mouse , 1997, Cell.
[153] P. Worley,et al. Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin. , 1997, Human molecular genetics.
[154] S. W. Davies,et al. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. , 1997, Science.
[155] Minoru Yoshida,et al. CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals , 1997, Cell.
[156] R. Vallee,et al. Fast transport and retrograde movement of huntingtin and HAP 1 in axons , 1997, Neuroreport.
[157] Mark Turmaine,et al. Formation of Neuronal Intranuclear Inclusions Underlies the Neurological Dysfunction in Mice Transgenic for the HD Mutation , 1997, Cell.
[158] K. Kinzler,et al. Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma , 1997, Science.
[159] H. Lehrach,et al. HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system. , 1997, Human molecular genetics.
[160] S. W. Davies,et al. Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice , 1996, Cell.
[161] B. Cullen,et al. A nuclear role for the Fragile X mental retardation protein. , 1996, The EMBO journal.
[162] J. D. den Dunnen,et al. Subcellular localization of the Huntington's disease gene product in cell lines by immunofluorescence and biochemical subcellular fractionation. , 1996, Human molecular genetics.
[163] S. Snyder,et al. Huntingtin-associated protein (HAP1): discrete neuronal localizations in the brain resemble those of neuronal nitric oxide synthase. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[164] S. Snyder,et al. A huntingtin-associated protein enriched in brain with implications for pathology , 1995, Nature.
[165] Peer Bork,et al. HEAT repeats in the Huntington's disease protein , 1995, Nature Genetics.
[166] Virginia E. Papaioannou,et al. Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue , 1995, Nature Genetics.
[167] Harry T Orr,et al. SCA1 transgenic mice: A model for neurodegeneration caused by an expanded CAG trinucleotide repeat , 1995, Cell.
[168] R. Carraway,et al. Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons , 1995, Neuron.
[169] F. Masiarz,et al. Association of the APC gene product with beta-catenin. , 1993, Science.
[170] K. Fenger,et al. Trinucleotide repeat elongation in the Huntingtin gene in Huntington disease patients from 71 Danish families. , 1993, Human molecular genetics.
[171] Manish S. Shah,et al. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes , 1993, Cell.
[172] C. Ingles,et al. Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein. , 1993, The Journal of biological chemistry.
[173] J. Greenblatt. Riding high on the TATA box , 1992, Nature.
[174] K. Fischbeck,et al. Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy , 1991, Nature.
[175] R. Ferrante,et al. Neuropathological Classification of Huntington's Disease , 1985, Journal of neuropathology and experimental neurology.
[176] M. Kelly,et al. SNARE complex regulation by phosphorylation , 2006, Cell Biochemistry and Biophysics.
[177] L. Tora,et al. Both normal and polyglutamine- expanded ataxin-7 are components of TFTC-type GCN5 histone acetyltransferase- containing complexes. , 2006, Biochemical Society symposium.
[178] G. Coetzee,et al. The androgen receptor: unlocking the secrets of its unique transactivation domain. , 2005, Vitamins and hormones.
[179] R. Kopito,et al. Impairment of the ubiquitin-proteasome system by protein aggregation. , 2001, Science.
[180] H. Zoghbi,et al. Glutamine repeats and neurodegeneration. , 2000, Annual review of neuroscience.
[181] M. Bissell,et al. Communication between the cell membrane and the nucleus: Role of protein compartmentalization , 1998, Journal of cellular biochemistry.
[182] Y. Wang,et al. Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. , 1997, Chemistry & biology.
[183] Murphy Ea,et al. Familial polyposis coli. , 1980, Progress in medical genetics.