VALZ‐Pilot: High‐dose valacyclovir treatment in patients with early‐stage Alzheimer's disease

Herpes simplex virus (HSV) may be involved in Alzheimer's disease (AD) pathophysiology. The antiviral valacyclovir inhibits HSV replication.

[1]  M. Roset,et al.  Assessing the Progression of Alzheimer’s Disease in Real-World Settings in Three European Countries , 2021, Journal of Alzheimer's disease : JAD.

[2]  P. Nordström,et al.  Herpesvirus infections, antiviral treatment, and the risk of dementia—a registry‐based cohort study in Sweden , 2021, Alzheimer's & dementia.

[3]  L. Nyberg,et al.  Antiviral treatment associated with reduced risk of clinical Alzheimer's disease—A nested case‐control study , 2021, Alzheimer's & dementia.

[4]  J. Del-Aguila,et al.  Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis , 2020, Science Translational Medicine.

[5]  G. Hallmans,et al.  An Ig γ Marker Genotype Is a Strong Risk Factor for Alzheimer Disease, Independent of Apolipoprotein E ε4 Genotype , 2020, The Journal of Immunology.

[6]  Joon Seo Lim,et al.  Association of herpes zoster with dementia and effect of antiviral therapy on dementia: a population-based cohort study , 2020, European Archives of Psychiatry and Clinical Neuroscience.

[7]  Y. Gustafson,et al.  Measurement error of the Mini-Mental State Examination among individuals with dementia that reside in nursing homes , 2020, European Journal of Ageing.

[8]  Nick C Fox,et al.  Cerebrospinal Fluid Biomarkers in Cerebral Amyloid Angiopathy , 2020, Journal of Alzheimer's disease : JAD.

[9]  L. Schneider.  Pragmatic Trials and Repurposed Drugs for Alzheimer Disease. , 2019, JAMA neurology.

[10]  G. Hallmans,et al.  A genetic signature including apolipoprotein Eε4 potentiates the risk of herpes simplex–associated Alzheimer's disease , 2019, Alzheimer's & dementia.

[11]  M. Weiner,et al.  Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease , 2019, Science Translational Medicine.

[12]  A. Goate,et al.  Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease , 2018, bioRxiv.

[13]  Rudolph E. Tanzi,et al.  Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection , 2018, Neuron.

[14]  Nathan D. Price,et al.  Summary of the 11th International Conference on Human Herpesviruses‐6A, ‐6B, and ‐7 , 2018, Neuron.

[15]  Fu-Huang Lin,et al.  Anti-herpetic Medications and Reduced Risk of Dementia in Patients with Herpes Simplex Virus Infections—a Nationwide, Population-Based Cohort Study in Taiwan , 2018, Neurotherapeutics.

[16]  Brian A. Gordon,et al.  Tau Kinetics in Neurons and the Human Central Nervous System , 2018, Neuron.

[17]  P. Calabresi,et al.  A new enzyme-linked immunosorbent assay for neurofilament light in cerebrospinal fluid: analytical validation and clinical evaluation , 2018, Alzheimer's Research & Therapy.

[18]  R. Adolfsson,et al.  Herpes virus seroepidemiology in the adult Swedish population , 2017, Immunity & Ageing.

[19]  S. Sutton,et al.  Use of High-Dose Oral Valacyclovir During an Intravenous Acyclovir Shortage: A Retrospective Analysis of Tolerability and Drug Shortage Management , 2017, Infectious Diseases and Therapy.

[20]  J. Molinuevo,et al.  Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease , 2016, Alzheimer's & Dementia.

[21]  Hugo Lövheim,et al.  Microbes and Alzheimer's Disease. , 2016, Journal of Alzheimer's disease : JAD.

[22]  K. Blennow,et al.  sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers , 2016, EMBO molecular medicine.

[23]  G. Hallmans,et al.  Herpes simplex infection and the risk of Alzheimer's disease: A nested case-control study , 2015, Alzheimer's & Dementia.

[24]  J. Gilthorpe,et al.  Reactivated herpes simplex infection increases the risk of Alzheimer's disease , 2015, Alzheimer's & Dementia.

[25]  U. Hjalmars,et al.  Human immunoglobulin G levels of viruses and associated glioma risk , 2011, Cancer Causes & Control.

[26]  J. Farrar,et al.  Valacyclovir for Herpes Simplex Encephalitis , 2011, Antimicrobial Agents and Chemotherapy.

[27]  M. Bullido,et al.  Apolipoprotein E genotyping method by Real Time PCR, a fast and cost-effective alternative to the TaqMan® and FRET assays , 2009, Journal of Neuroscience Methods.

[28]  MA Wozniak,et al.  Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques , 2009, The Journal of pathology.

[29]  P. Barberger‐Gateau,et al.  Seropositivity to Herpes Simplex Virus Antibodies and Risk of Alzheimer's Disease: A Population-Based Cohort Study , 2008, PloS one.

[30]  P. Bhattarakosol,et al.  Acyclovir susceptibility of herpes simplex virus isolates at King Chulalongkorn Memorial Hospital, Bangkok. , 2008, Journal of the Medical Association of Thailand = Chotmaihet thangphaet.

[31]  L. Hutt-Fletcher.  Faculty Opinions recommendation of PILRalpha is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B. , 2008 .

[32]  L. Lanier,et al.  PILRα Is a Herpes Simplex Virus-1 Entry Coreceptor That Associates with Glycoprotein B , 2008, Cell.

[33]  M. Wozniak,et al.  Herpes simplex virus infection causes cellular β-amyloid accumulation and secretase upregulation , 2007, Neuroscience Letters.

[34]  J. Julien,et al.  New movements in neurofilament transport, turnover and disease. , 2007, Experimental cell research.

[35]  A. Wald,et al.  Valacyclovir and acyclovir for suppression of shedding of herpes simplex virus in the genital tract. , 2004, The Journal of infectious diseases.

[36]  L. Ståhle,et al.  Acyclovir Levels in Serum and Cerebrospinal Fluid after Oral Administration of Valacyclovir , 2003, Antimicrobial Agents and Chemotherapy.

[37]  L. Guse,et al.  An examination of psychometric properties of the mini-mental state examination and the standardized mini-mental state examination: implications for clinical practice. , 2000, Applied nursing research : ANR.

[38]  S. Tyring,et al.  Antiviral therapy for herpes zoster: randomized, controlled clinical trial of valacyclovir and famciclovir therapy in immunocompetent patients 50 years and older. , 2000, Archives of family medicine.

[39]  L. Corey,et al.  A Randomized, Placebo-Controlled Comparison of Oral Valacyclovir and Acyclovir in Immunocompetent Patients With Recurrent Genital Herpes Infections , 1998 .

[40]  G. Wilcock,et al.  Herpes simplex virus type 1 in brain and risk of Alzheimer's disease , 1997, The Lancet.

[41]  D. Friedman,et al.  Valaciclovir compared with acyclovir for improved therapy for herpes zoster in immunocompetent adults , 1995, Antimicrobial agents and chemotherapy.

[42]  C. Gillberg,et al.  A sensitive ELISA for glial fibrillary acidic protein: application in CSF of children , 1992, Journal of Neuroscience Methods.

[43]  P. Juto,et al.  Specific serum IgA, IgG and IgM antibody determination by a modified indirect ELISA-technique in primary and recurrent herpes simplex virus infection. , 1988, Journal of virological methods.

[44]  M. Ball.  “Limbic Predilection in Alzheimer Dementia: Is Reactivated Herpesvirus Involved?” , 1982, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[45]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[46]  L. Nyberg,et al.  Herpes Simplex Virus, APOEɛ4, and Cognitive Decline in Old Age: Results from the Betula Cohort Study. , 2019, Journal of Alzheimer's disease : JAD.

[47]  G. Hallmans,et al.  Interaction between Cytomegalovirus and Herpes Simplex Virus Type 1 Associated with the Risk of Alzheimer's Disease Development. , 2018, Journal of Alzheimer's disease : JAD.

[48]  Henrik Zetterberg,et al.  Association of Cerebrospinal Fluid Neurofilament Light Concentration With Alzheimer Disease Progression. , 2016, JAMA neurology.

[49]  G. Eslick,et al.  Herpes Viruses Increase the Risk of Alzheimer's Disease: A Meta-Analysis. , 2015, Journal of Alzheimer's disease : JAD.