Dibenzocyclooctadiene Lignans from Artemisia sieversiana and Their Nitric Oxide Inhibitory Effects

Two previously undescribed dibenzocyclooctadiene lignans, named sieverlignans D–E (1-2), as well as eight known ones (3-10), were isolated from the aerial parts of Artemisia sieversiana. Their structures were elucidated from extensive spectroscopic analysis, including HRMS, NMR and circular dichroism experiments. This study is the first to report dibenzocyclooctadiene lignans in the genus Artemisia and this plant. All the compounds were evaluated for their anti-neuroinflammatory effects on the lipopolysaccharides (LPS)-induced nitric oxide production in BV-2 murine microglial cells. Compounds 1 and 6 exhibited the moderate activity with their IC50 values of 47.7 and 21.9 μM, compared to a positive control quercetin with the IC50 value of 16.0 μM.

[1]  Kewu Zeng,et al.  New terpenoids and thiophene derivatives from the aerial parts of Artemisia sieversiana. , 2017, Bioorganic & medicinal chemistry letters.

[2]  Kewu Zeng,et al.  Artesin A, a new cage-shaped dimeric guaianolide from Artemisia sieversiana , 2015 .

[3]  K. Lee,et al.  Neglschisandrins E–F: Two New Lignans and Related Cytotoxic Lignans from Schisandra neglecta , 2013, Molecules.

[4]  Da-yuan Zhu,et al.  Two new lignans from Celastrus flagellaris Rupr. , 2012, Journal of Asian natural products research.

[5]  Pei Yue-hu.  Application of CD in study of the absolute configuration of lignans , 2010 .

[6]  K. Lee,et al.  Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora. , 2006, Journal of natural products.

[7]  Wei‐Lie Xiao,et al.  Anti2HIV Lignans from Schisandra micrantha , 2005 .

[8]  Long-zhen Piao,et al.  Dibenzocyclooctene lignan compounds isolated from the fruits of Schisandra chinensis Baill , 2005 .

[9]  Jiang Si.  Sphenanlignan ,a New Lignan from the Seeds of Schisandra sphenanthera , 2005 .

[10]  Chen Hai-yong.  An NMR Study of Two Lignans Isolated from Schisandra Chinensis , 2005 .

[11]  W. Qin.  Studies on the chemical constituents of Artemisia sieversiana and their anticancer activities , 2004 .

[12]  R. Tan,et al.  Terpenoids and flavonoids from Artemisia species. , 2000, Planta medica.

[13]  R. Tan,et al.  Lignans and sesquiterpene lactones from Artemisia sieversiana and Inula racemosa. , 1998, Phytochemistry.

[14]  I. Yosioka,et al.  The constituents of Schizandra chinensis Baill. VI. 13C nuclear magnetic resonance spectroscopy of dibenzocyclooctadiene lignans. , 1980 .