NEW ANTIFUNGAL ANTIBIOTIC

In the course of our screening programs for new antifungal antibiotics, a new fungal metabolite, synerazol* was isolated. The producing organism of synerazol was identified as Aspergillus fumigatus, which was isolated from a soil sample collected in Thailand. Synerazol was active against fungi including Candida albicans. The activity was highly potentiated by the presence of a low concentration of azole antifungal agents. In this paper, the taxonomy of a producing strain, isolation, physico-chemical properties, structure elucidation, and biological activity of synerazol are described.

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