Primary tumours of the ciliary body include adenoma ,

Primary tumours of the ciliary body include adenoma, Fuch’s adenoma, and adenocarcinoma. The adenoma can be easily distinguished by lack of infiltrative behaviour and relatively rare mitosis. Similarly, ciliary body adenocarcinomas—including those arising from NPCE—are rare and have been reported in all age groups. It has been believed that these arise as a reactive proliferation secondary to trauma or inflammation. These ciliary body masses are nonpigmented and irregular, have the tendency to cause localized cataract changes, and can be associated with sentinel vessels. Differential diagnosis of this tumour includes medulloepitheloma, adenoma, melanoma, and metastasis. IHC studies have shown that these tumours stain positive with S-100 protein and vimentin as they originate from NPCE. They can show positivity with Kermix, CAM 5.2, and CK7. Since we have encountered the aforementioned 2 cases in which the adenocarcinoma had originated from 2 different intraocular structures, we have summarized the differentiating features between those tumours arising from the NPCE and the ones arising from RPE in Table 1. In conclusion, intraocular adenocarcinomas may constitute diagnostic challenge to the ophthalmic pathologist. Good knowledge of the characteristic features and careful examination of routine evisceration tissue are a must to avoid overlooking such tumours or misdiagnosis especially when an underlying neoplasm is unsuspected.