Oncogenic KRAS signalling in pancreatic cancer
暂无分享,去创建一个
D Saur | D. Saur | A. Schnieke | G. Schneider | S. Eser | G. Schneider | S Eser | A Schnieke | G Schneider
[1] C. Galbán,et al. Metastatic Pancreatic Cancer Is Dependent on Oncogenic Kras in Mice , 2012, PloS one.
[2] B. Spencer‐Dene,et al. Requirement for Interaction of PI3-Kinase p110α with RAS in Lung Tumor Maintenance , 2013, Cancer cell.
[3] P. Bastiaens,et al. Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling , 2013, Nature.
[4] Julian Downward,et al. Coordinate direct input of both KRAS and IGF1 receptor to activation of PI3 kinase in KRAS-mutant lung cancer. , 2013, Cancer discovery.
[5] Gerald C. Chu,et al. Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism , 2012, Cell.
[6] M. Shipitsin,et al. Activation of RalA is critical for Ras-induced tumorigenesis of human cells. , 2005, Cancer cell.
[7] C. Galbán,et al. Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice. , 2012, The Journal of clinical investigation.
[8] P. Spellman,et al. Subtypes of Pancreatic Ductal Adenocarcinoma and Their Differing Responses to Therapy , 2011, Nature Medicine.
[9] Sarat Chandarlapaty,et al. Negative feedback and adaptive resistance to the targeted therapy of cancer. , 2012, Cancer discovery.
[10] D. Bar-Sagi,et al. RAS oncogenes: weaving a tumorigenic web , 2011, Nature Reviews Cancer.
[11] M. Hebrok,et al. KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma , 2010, Nature Reviews Cancer.
[12] R. Bernards,et al. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR , 2012, Nature.
[13] D. Saur,et al. A Cre-loxP-based mouse model for conditional somatic gene expression and knockdown in vivo by using avian retroviral vectors , 2008, Proceedings of the National Academy of Sciences.
[14] D. Tuveson,et al. C-Raf is required for the initiation of lung cancer by K-Ras(G12D). , 2011, Cancer discovery.
[15] P. Murawa,et al. Erlotinib Plus Gemcitabine Compared With Gemcitabine Alone in Patients With Advanced Pancreatic Cancer: A Phase III Trial of the National Cancer Institute of Canada Clinical Trials Group , 2023, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[16] Travis J Cohoon,et al. Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models. , 2013, Cancer cell.
[17] P. Mazur,et al. Early requirement of Rac1 in a mouse model of pancreatic cancer. , 2011, Gastroenterology.
[18] H. Höfler,et al. Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues , 2012, The Journal of pathology.
[19] C. Sander,et al. V600EBRAF is associated with disabled feedback inhibition of RAF–MEK signaling and elevated transcriptional output of the pathway , 2009, Proceedings of the National Academy of Sciences.
[20] Kevan M. Shokat,et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions , 2013, Nature.
[21] Gerald C. Chu,et al. PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network. , 2011, Cancer discovery.
[22] A. Biankin,et al. Understanding pancreatic cancer genomes , 2013, Journal of hepato-biliary-pancreatic sciences.
[23] Lincoln D. Stein,et al. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes , 2012, Nature.
[24] Dhiraj Yadav,et al. The epidemiology of pancreatitis and pancreatic cancer. , 2013, Gastroenterology.
[25] Qi Sun,et al. Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. , 2012, Angewandte Chemie.
[26] T. Eberlein,et al. Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation , 2012 .
[27] John M. Asara,et al. Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway , 2013, Nature.
[28] M. Barbacid,et al. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. , 2007, Cancer cell.
[29] R. Rad,et al. Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer. , 2013, Cancer cell.
[30] M. Barbacid,et al. c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma. , 2011, Cancer cell.
[31] A. Tolcher,et al. The Clinical Effect of the Dual-Targeting Strategy Involving PI3K/AKT/mTOR and RAS/MEK/ERK Pathways in Patients with Advanced Cancer , 2012, Clinical Cancer Research.
[32] Pierre Michel,et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. , 2011, The New England journal of medicine.
[33] S. Adam,et al. Divergent Roles for RalA and RalB in Malignant Growth of Human Pancreatic Carcinoma Cells , 2006, Current Biology.
[34] S. Sebti,et al. Targeting protein prenylation for cancer therapy , 2011, Nature Reviews Cancer.
[35] K. Moelling,et al. Phosphorylation and regulation of Raf by Akt (protein kinase B). , 1999, Science.
[36] Magnus Bosse,et al. Regulation of Raf-Akt Cross-talk , 2002, The Journal of Biological Chemistry.
[37] H. Friess,et al. StellaTUM: current consensus and discussion on pancreatic stellate cell research , 2011, Gut.
[38] M. Baccarini,et al. MEK1 Is Required for PTEN Membrane Recruitment, AKT Regulation, and the Maintenance of Peripheral Tolerance , 2013, Molecular cell.
[39] B. Spencer‐Dene,et al. Requirement for Interaction of PI3-Kinase p110 alpha with RAS in Lung Tumor Maintenance , 2013 .
[40] Laura M. Heiser,et al. A central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma. , 2012, Cancer discovery.
[41] M. Kanda,et al. Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia. , 2012, Gastroenterology.
[42] Ralph Weissleder,et al. Effective Use of PI3K and MEK Inhibitors to Treat Mutant K-Ras G12D and PIK3CA H1047R Murine Lung Cancers , 2008, Nature Medicine.
[43] G. Feldmann,et al. Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signaling. , 2010, Cancer research.
[44] Julian Downward,et al. RAS Interaction with PI3K: More Than Just Another Effector Pathway. , 2011, Genes & cancer.
[45] N. Jamieson,et al. Exploiting inflammation for therapeutic gain in pancreatic cancer , 2013, British Journal of Cancer.
[46] David Goldstein,et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. , 2013, The New England journal of medicine.
[47] M. Barbacid,et al. EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma. , 2012, Cancer cell.
[48] I. Mellman,et al. Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity , 2012, Proceedings of the National Academy of Sciences.
[49] O. Warburg. [Origin of cancer cells]. , 1956, Oncologia.
[50] E. Petricoin,et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. , 2003, Cancer cell.
[51] Patricia Greninger,et al. A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival. , 2009, Cancer cell.
[52] J. Kleeff,et al. Disclosure of erlotinib as a multikinase inhibitor in pancreatic ductal adenocarcinoma. , 2011, Neoplasia.
[53] G. Parmigiani,et al. Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses , 2008, Science.
[54] Jens T Siveke,et al. EGF receptor is required for KRAS-induced pancreatic tumorigenesis. , 2012, Cancer cell.