The Impact of Recent Technological Advances on the Trueness and Precision of DXA to Assess Body Composition

The introduction of dual‐energy X‐ray absorptiometry (DXA) in the 1980s for the assessment of areal bone mineral density (BMD) greatly benefited the field of bone imaging and the ability to diagnose and monitor osteoporosis. The additional capability of DXA to differentiate between bone mineral, fat tissue, and lean tissue has contributed to its emergence as a popular tool to assess body composition. Throughout the past 2 decades, technological advancements such as the transition from the original pencil‐beam densitometers to the most recent narrow fan‐beam densitometers have allowed for faster scan times and better resolution. The majority of reports that have compared DXA‐derived body composition measurements to the gold standard method of body composition appraisal, the four‐compartment model, have observed significant differences with this criterion method; however, the extent to which the technological advancements of the DXA have impacted its ability to accurately assess body composition remains unclear. Thus, this paper reviews the evidence regarding the trueness and precision of DXA body composition measurements from the pencil‐beam to the narrow fan‐beam densitometers.

[1]  R B Mazess,et al.  Dual-energy x-ray absorptiometry for total-body and regional bone-mineral and soft-tissue composition. , 1990, The American journal of clinical nutrition.

[2]  M. Helba,et al.  Pediatric body composition analysis with dual-energy X-ray absorptiometry , 2009, Pediatric Radiology.

[3]  G. Blake,et al.  Dual X-ray absorptiometry: a comparison between fan beam and pencil beam scans. , 1993, The British journal of radiology.

[4]  J. Yanovski,et al.  Comparison of methods to assess change in children's body composition. , 2004, The American journal of clinical nutrition.

[5]  H. S. Bayley,et al.  Validation and application of dual-energy x-ray absorptiometry to measure bone mass and body composition in small infants. , 1993, The American journal of clinical nutrition.

[6]  P. Sparling,et al.  Comparison of body composition and bone mineral measurements from two DXA instruments in young men. , 1996, The American journal of clinical nutrition.

[7]  E. Evans,et al.  Body-composition changes with diet and exercise in obese women: a comparison of estimates from clinical methods and a 4-component model. , 1999, The American journal of clinical nutrition.

[8]  Zhi-Li Zhang,et al.  Measurement precision of body composition variables using the lunar DPX-L densitometer. , 2000, Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.

[9]  R. Shepherd,et al.  Lack of sensitivity of weight targets compared with body cell mass for determining recovery from malnutrition in adolescents with anorexia nervosa. , 1998, The International journal of eating disorders.

[10]  S. Heymsfield,et al.  Accuracy of DXA in estimating body composition changes in elite athletes using a four compartment model as the reference method , 2010, Nutrition & metabolism.

[11]  S B Heymsfield,et al.  Dual-energy X-ray absorptiometry body composition model: review of physical concepts. , 1996, The American journal of physiology.

[12]  W. D. van Marken Lichtenbelt,et al.  Body composition changes in bodybuilders: a method comparison. , 2004, Medicine and science in sports and exercise.

[13]  N. Bishop,et al.  DXA in Adults and Children , 2013 .

[14]  S B Heymsfield,et al.  Use of dual-energy x-ray absorptiometry in body-composition studies: not yet a "gold standard". , 1993, The American journal of clinical nutrition.

[15]  P. Teixeira,et al.  Usefulness of different techniques for measuring body composition changes during weight loss in overweight and obese women , 2008, British Journal of Nutrition.

[16]  D. Haroun,et al.  Evaluation of Lunar Prodigy dual-energy X-ray absorptiometry for assessing body composition in healthy persons and patients by comparison with the criterion 4-component model. , 2006, The American journal of clinical nutrition.

[17]  K. Ward,et al.  Tools for Measuring Bone in Children and Adolescents , 2007 .

[18]  H. Genant,et al.  Clinical applications of body composition measurements using DXA. , 2003, Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.

[19]  R. Shepherd,et al.  Change in body mass index does not predict change in body composition in adolescent girls with anorexia nervosa. , 2000, Journal of the American Dietetic Association.

[20]  M. A. Collins,et al.  Impact of bone mineral estimates on percent fat estimates from a four-component model. , 1999, Medicine and science in sports and exercise.

[21]  C. Christiansen,et al.  Accuracy of measurements of body composition by dual-energy x-ray absorptiometry in vivo. , 1993, The American journal of clinical nutrition.

[22]  Bess Dawson-Hughes,et al.  Precision and stability of dual-energy X-ray absorptiometry measurements , 1991, Calcified Tissue International.

[23]  M. Vitolo,et al.  Accuracy of obesity diagnosis in Brazilian adolescents: comparison of Cole et al and Must et al criteria with DXA percentage of fat mass. , 2006, Nutricion hospitalaria.

[24]  P. Tothill,et al.  Comparisons between a pencil beam and two fan beam dual energy X-ray absorptiometers used for measuring total body bone and soft tissue. , 2001, The British journal of radiology.

[25]  B. Salle Bone densitometry in growing patients – guidelines for clinical practice , 2008 .

[26]  P. Tothill,et al.  Comparisons between Hologic, Lunar and Norland dual-energy X-ray absorptiometers and other techniques used for whole-body soft tissue measurements. , 1994, European journal of clinical nutrition.

[27]  S. Norris,et al.  Regression equations to estimate percentage body fat in African prepubertal children aged 9 y. , 2004, The American journal of clinical nutrition.

[28]  M. Griffiths,et al.  Correcting the Magnification Error of Fan Beam Densitometers , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[29]  Tamara B Harris,et al.  Comparisons of percentage body fat, body mass index, waist circumference, and waist-stature ratio in adults. , 2009, The American journal of clinical nutrition.

[30]  D. Ducassou,et al.  Comparison of two Hologic DXA systems (QDR 1000 and QDR 4500/A). , 1997, The British journal of radiology.

[31]  F. Greenway,et al.  Comparison of methods to assess body composition changes during a period of weight loss. , 2005, Obesity research.

[32]  M. Litaker,et al.  Comparison of Hologic QDR-1000/W and 4500W DXA Scanners in 13- to 18-Year Olds. , 2003, Obesity research.

[33]  L. Plank,et al.  Dual-energy X-ray absorptiometry and body composition , 2005, Current opinion in clinical nutrition and metabolic care.

[34]  June Hawkinson,et al.  Technical white paper: bone densitometry. , 2007, Journal of the American College of Radiology : JACR.

[35]  Gregory J Welk,et al.  Assessing body composition among 3- to 8-year-old children: anthropometry, BIA, and DXA. , 2004, Obesity research.

[36]  R. Baumgartner,et al.  Body composition of humans: comparison of two improved four-compartment models that differ in expense, technical complexity, and radiation exposure. , 1990, The American journal of clinical nutrition.

[37]  W. Coward,et al.  Four-component model for the assessment of body composition in humans: comparison with alternative methods, and evaluation of the density and hydration of fat-free mass. , 1992, Clinical science.

[38]  K Engelke,et al.  Quality and performance measures in bone densitometry: part 1: errors and diagnosis. , 2006, Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.

[39]  Martin Torriani,et al.  Comparison of DXA and CT in the Assessment of Body Composition in Premenopausal Women With Obesity and Anorexia Nervosa , 2010, Obesity.

[40]  J. Thorpe,et al.  Image Resolution of the Lunar Expert-XL , 1999, Osteoporosis International.

[41]  M. Goran,et al.  Cross-calibration of fat and lean measurements by dual-energy X-ray absorptiometry to pig carcass analysis in the pediatric body weight range. , 1996, The American journal of clinical nutrition.

[42]  H. Barrera-Saldana,et al.  Critical appraisal of the estimation of body composition via two‐, three‐, and four‐compartment models , 1999, American journal of human biology : the official journal of the Human Biology Council.

[43]  R. Withers,et al.  Validation of DXA Body Composition Estimates in Obese Men and Women , 2009, Obesity.

[44]  T. Nagata,et al.  Altered body fat distribution after recovery of weight in patients with anorexia nervosa. , 1999, The International journal of eating disorders.

[45]  P. Deurenberg,et al.  Measurement of body fat in young and elderly women: comparison between a four-compartment model and widely used reference methods , 1996, British Journal of Nutrition.

[46]  C. Pichard,et al.  Comparison of body weight and composition measured by two different dual energy X-ray absorptiometry devices and three acquisition modes in obese women. , 2006, Clinical nutrition.

[47]  A. Field,et al.  Which metric of relative weight best captures body fatness in children? , 2003, Obesity research.

[48]  J. Picaud,et al.  Evaluation of dual-energy X-ray absorptiometry for body-composition assessment in piglets and term human neonates. , 1996, The American journal of clinical nutrition.

[49]  K. Hind,et al.  In vivo precision of the GE Lunar iDXA densitometer for the measurement of total body composition and fat distribution in adults , 2011, European Journal of Clinical Nutrition.

[50]  D. Schoeller,et al.  QDR 4500A dual-energy X-ray absorptiometer underestimates fat mass in comparison with criterion methods in adults. , 2005, The American journal of clinical nutrition.

[51]  V. Boudousq,et al.  Image resolution and magnification using a cone beam densitometer: optimizing data acquisition for hip morphometric analysis , 2005, Osteoporosis International.

[52]  E. Evans,et al.  In vivo validation of whole body composition estimates from dual-energy X-ray absorptiometry. , 1997, Journal of applied physiology.

[53]  Sheila M. Williams,et al.  Body fat percentages measured by dual-energy X-ray absorptiometry corresponding to recently recommended body mass index cutoffs for overweight and obesity in children and adolescents aged 3-18 y. , 2002, The American journal of clinical nutrition.

[54]  R. Withers,et al.  Percent body fat via DEXA: comparison with a four-compartment model. , 2003, Journal of applied physiology.

[55]  B. Oldroyd,et al.  Cross-calibration of GE/Lunar pencil and fan-beam dual energy densitometers—bone mineral density and body composition studies , 2003, European Journal of Clinical Nutrition.

[56]  K. Westerterp,et al.  Assessment of fat-mass loss during weight reduction in obese women. , 1997, Metabolism: clinical and experimental.

[57]  T. Lohman,et al.  Reproducibility of DXA in obese women. , 2002, Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.

[58]  P. Deurenberg,et al.  Body fat measurement among Singaporean Chinese, Malays and Indians: a comparative study using a four-compartment model and different two-compartment models , 2001, British Journal of Nutrition.

[59]  M. Griffiths,et al.  Magnification error of femoral geometry using fan beam densitometers , 2009, Calcified Tissue International.

[60]  R. Withers,et al.  Comparisons of two-, three-, and four-compartment models of body composition analysis in men and women. , 1998, Journal of applied physiology.

[61]  G. Blake,et al.  Patient dose in dual x-ray absorptiometry , 2006, Osteoporosis International.

[62]  D. Gaudet,et al.  Hypertriglyceridemic waist: A marker of the atherogenic metabolic triad (hyperinsulinemia; hyperapolipoprotein B; small, dense LDL) in men? , 2000, Circulation.

[63]  John A. Kanis Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism , 2000 .

[64]  Paul Zimmet,et al.  The metabolic syndrome—a new worldwide definition , 2005, The Lancet.

[65]  T. Winzenberg,et al.  Dual energy X-ray absorptiometry. , 2011, Australian family physician.

[66]  E. Evans,et al.  Validation of body composition estimates in male and female distance runners using estimates from a four‐component model , 2000, American journal of human biology : the official journal of the Human Biology Council.

[67]  Measurement of body composition changes with weight loss in postmenopausal women: comparison of methods. , 2007, The journal of nutrition, health & aging.

[68]  W. Hannan,et al.  Body mass index as an estimate of body fat. , 1995, The International journal of eating disorders.

[69]  Vuk Vrhovac THE METABOLIC SYNDROME – AN ONGOING STORY , 2010 .

[70]  D Resnick,et al.  Dual-energy radiographic absorptiometry for bone densitometry: current status and perspective. , 1989, AJR. American journal of roentgenology.

[71]  Jack Wang,et al.  iDXA, Prodigy, and DPXL dual-energy X-ray absorptiometry whole-body scans: a cross-calibration study. , 2009, Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.