One of the major problems in the analysis of Electro-Cardiogram (ECG) signal compression is the accurate detection of R-peak. It is due to the difficulties varied by the time varying morphology of ECG, the physiological variations due to the patient and the noise contamination. However, it includes power line interface, muscle contraction noise, poor electrode contact, patient movement, and baseline wandering due to respiration. R-peak applications require accurate heart beat monitoring systems including intensive care units, operating rooms, implantable pacemakers and defibrillators. Moreover, it detects a QRS complex when ECG amplitude exceeds a threshold level. If the threshold is too high, true beats can be missed. If the threshold is too low, false detection can result during EMG artifact and external interface. So, during these artifacts, the magnitude of the noise can become larger than the signal, QRS detection based on amplitude threshold alone is not satisfactory. The problem was due to the detection threshold used, not the matched filter implementation. The R peak detection threshold was two-thirds of the average value of the output of the matched filter for the specific feature of interest. To overcome this problem, R peak detection has been proposed because it is adaptive to the nonlinear and time varying features of ECG signal. It can be trained to recognize the normal waveform and filter out the unnecessary artifacts and noises. Usually R-peak detection in QRS complex can be improved by considering multiple features, including RR interval, pulse duration and amplitude. In this research paper, is to take the difference of maximum original signal and minimum original signal to obtain the filtered R-peak ECG signal after 1 st and 2 nd pass to observe noise for 512 sample points at sampling frequency of 1 KHz using High Order Statistics Algorithm.Once the Rpeak is detected, compute the Mean Square Error (MSE) and Peak Signal to Noise Ratio (PSNR). From analytical perspective of this research, it appears to be exceedingly robust, correctly detects R-peaks even aberrant QRS complexes in noise-corrupted ECG signal compression. Keywords—component; ECG, R-Peak, QRS, FFT, High Order Statistics Algorithm, Threshold, Skewness, Kurtosis, Power Spectrum Density,
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