Effect of cushing response on systemic arterial pressure

This work investigates the complex relationships between cerebrovascular dynamics, intracranial pressure (ICP), Cushing response, and short-term systemic regulation via an original mathematical model. The model has been used to analyze the effects of Cushing response on cardiovascular and cerebrovascular quantities during constant ICP elevation and during the occurrence of ICP plateau waves and to investigate the conditions leading to system instability with the formation of slow (0.05-0.1 Hz) arterial pressure waves. The model may be of value to assist clinicians in finding the balance between clinical benefits of Cushing response and its shortcomings.

[1]  M Ursino.  Modelling the interaction among several mechanisms in the short-term arterial pressure control. , 2000, Studies in health technology and informatics.

[2]  A A Shoukas,et al.  Control of Total Systemic Vascular Capacity by the Carotid Sinus Baroreceptor Reflex , 1973, Circulation research.

[3]  M. Ursino,et al.  A mathematical model of the relationship between cerebral blood volume and intracranial pressure changes: The generation of plateau waves , 2006, Annals of Biomedical Engineering.

[4]  L Beydon,et al.  Cerebral hemodynamics during arterial and CO(2) pressure changes: in vivo prediction by a mathematical model. , 2000, American journal of physiology. Heart and circulatory physiology.

[5]  R. Koehler,et al.  Influence of CO2 on cardiovascular response to hypoxia in conscious dogs. , 1980, The American journal of physiology.

[6]  G. Bouma,et al.  Cerebral blood flow, cerebral blood volume, and cerebrovascular reactivity after severe head injury. , 1992, Journal of neurotrauma.

[7]  T. Ducker,et al.  Increased Intracranial Pressure and Pulmonary Edema Part 2 : The Hemodynamic Response of Dogs and Monkeys to Increased Intracranial Pressure , 2022 .

[8]  Charles Tator,et al.  Increased intracranial pressure elicits hypertension, increased sympathetic activity, electrocardiographic abnormalities and myocardial damage in rats. , 1988, Journal of the American College of Cardiology.

[9]  E Magosso,et al.  A mathematical model of CO2 effect on cardiovascular regulation. , 2001, American journal of physiology. Heart and circulatory physiology.

[10]  佐川 喜一,et al.  Cardiac contraction and the pressure-volume relationship , 1988 .

[11]  H. I. Chen,et al.  Systemic and pulmonary hemodynamic responses to intracranial hypertension. , 1984, The American journal of physiology.

[12]  N. Lundberg,et al.  Continuous recording and control of ventricular fluid pressure in neurosurgical practice. , 1962, Acta psychiatrica Scandinavica. Supplementum.

[13]  A C GUYTON,et al.  Vasomotor waves possibly resulting from CNS ischemic reflex oscillation. , 1952, The American journal of physiology.

[14]  E. Feigl.  Neural Control of Coronary Blood Flow , 1998, Journal of Vascular Research.

[15]  J. Patterson,et al.  Responses of cerebral arteries and arterioles to acute hypotension and hypertension. , 1978, The American journal of physiology.

[16]  A A Shoukas,et al.  Epinephrine and the Carotid Sinus Baroreceptor Reflex: Influence on Capacitive and Resistive Properties of the Total Systemic Vascular Bed of the Dog , 1980, Circulation research.

[17]  Peter E Hammer,et al.  Resonance in a mathematical model of baroreflex control: arterial blood pressure waves accompanying postural stress. , 2005, American journal of physiology. Regulatory, integrative and comparative physiology.

[18]  M. Rosner,et al.  Origin and evolution of plateau waves. Experimental observations and a theoretical model. , 1984, Journal of neurosurgery.

[19]  C. Plets.  Arterial hypertension in neurosurgical emergencies. , 1989, The American journal of cardiology.

[20]  N. Secher,et al.  Point:Counterpoint: Sympathetic activity does/does not influence cerebral blood flow. Point: Sympathetic activity does influence cerebral blood flow. , 2008, Journal of applied physiology.

[21]  Ming-Che Lee,et al.  A severe vicious cycle in uncontrolled subarachnoid hemorrhage: the effects on cerebral blood flow and hemodynamic responses upon intracranial hypertension. , 2006, The Chinese journal of physiology.

[22]  E Magosso,et al.  Acute cardiovascular response to isocapnic hypoxia. I. A mathematical model. , 2000, American journal of physiology. Heart and circulatory physiology.

[23]  M. Ursino,et al.  Interaction among autoregulation, CO2 reactivity, and intracranial pressure: a mathematical model. , 1998, American journal of physiology. Heart and circulatory physiology.

[24]  T. Ducker,et al.  Increased intracranial pressure and pulmonary edema. 2. The hemodynamic response of dogs and monkeys to increased intracranial pressure. , 1968, Journal of neurosurgery.

[25]  R. M'Dowall.  A CHEMICAL CONTROL OF THE HEART‐RATE , 1933 .

[26]  N. Hirano,et al.  Relationship of hypotension and cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage , 2006, Neurological research.

[27]  L A Marshman,et al.  Cushing's 'variant' response (acute hypotension) after subarachnoid hemorrhage. Association with moderate intracranial tensions and subacute cardiovascular collapse. , 1997, Stroke.

[28]  M. Ursino,et al.  A simple mathematical model of the interaction between intracranial pressure and cerebral hemodynamics. , 1997, Journal of applied physiology.

[29]  C. Su,et al.  EFFECTS OF INTRACRANIAL HYPERTENSION ON STEADY AND PULSATILE HAEMODYNAMICS IN DOGS , 1999, Clinical and experimental pharmacology & physiology.

[30]  M. Ursino,et al.  Interaction between carotid baroregulation and the pulsating heart : a mathematical model , 1998 .

[31]  C. Julien.  The enigma of Mayer waves: Facts and models. , 2006, Cardiovascular research.