Regulation of drug-metabolizing enzymes by local and systemic liver injuries

ABSTRACT Introduction: Drug metabolism and disposition are critical in maintaining the chemical and functional homeostasis of xenobiotics/drugs and endobiotics. The liver plays an essential role in drug metabolism and disposition due to its abundant expression of drug-metabolizing enzymes (DMEs) and transporters. There is growing evidence to suggest that many hepatic and systemic diseases can affect drug metabolism and disposition by regulating the expression and/or activity of DMEs and transporters in the liver. Areas covered: This review focuses on the recent progress on the regulation of DMEs by local and systemic liver injuries. Liver ischemia and reperfusion (I/R) and sepsis are used as examples of local and systemic injury, respectively. The reciprocal effect of the expression and activity of DMEs on animals’ sensitivity to local and systemic liver injuries is also discussed. Expert opinion: Local and systemic liver injuries have a major effect on the expression and activity of DMEs in the liver. Understanding the disease effect on DMEs is clinically important due to the concern of disease-drug interactions. Future studies are necessary to understand the mechanism by which liver injury regulates DMEs. Human studies are also urgently needed in order to determine whether the results in animals can be replicated in human patients.

[1]  M. Huang,et al.  Estrogen sulfotransferase ablation sensitizes mice to sepsis , 2015, Nature Communications.

[2]  U. Hofmann,et al.  Inflammation-Associated MicroRNA-130b Down-Regulates Cytochrome P450 Activities and Directly Targets CYP2C9 , 2015, Drug Metabolism and Disposition.

[3]  M. Huang,et al.  Estrogen Sulfotransferase Is an Oxidative Stress-responsive Gene That Gender-specifically Affects Liver Ischemia/Reperfusion Injury* , 2015, The Journal of Biological Chemistry.

[4]  Edward T Chouchani,et al.  Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS , 2014, Nature.

[5]  Y. Liu,et al.  Assessment of effects of IR and IPC on activities of cytochrome P450 isozymes in rats by a five-drug cocktail approach , 2014, Drug development and industrial pharmacy.

[6]  M. Singer.  The role of mitochondrial dysfunction in sepsis-induced multi-organ failure , 2013, Virulence.

[7]  M. Joannidis,et al.  Histologic Pathologies of the Myocardium in Septic Shock: A Prospective Observational Study , 2013, Shock.

[8]  H. Fujino,et al.  Effect of lipopolysaccharide on the xenobiotic-induced expression and activity of hepatic cytochrome P450 in mice. , 2012, Biological & pharmaceutical bulletin.

[9]  T. Eckle,et al.  Ischemia and reperfusion—from mechanism to translation , 2011, Nature Medicine.

[10]  Y. Zhai,et al.  Liver Ischemia and Reperfusion Injury: New Insights into Mechanisms of Innate—Adaptive Immune‐Mediated Tissue Inflammation , 2011, American Journal of Transplantation.

[11]  Sun-Mee Lee,et al.  Role of Kupffer cells in pathogenesis of sepsis‐induced drug metabolizing dysfunction , 2011, The FEBS journal.

[12]  J. Hoeijmakers,et al.  Preoperative fasting protects mice against hepatic ischemia/reperfusion injury: mechanisms and effects on liver regeneration , 2011, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[13]  S. Shyue,et al.  Impaired Cd14 and Cd36 Expression, Bacterial Clearance, and Toll-Like Receptor 4-Myd88 Signaling in Caveolin-1-Deleted Macrophages and Mice , 2011, Shock.

[14]  K. Langa,et al.  Long-term cognitive impairment and functional disability among survivors of severe sepsis. , 2010, JAMA.

[15]  A. Tsung,et al.  Molecular biology of liver ischemia/reperfusion injury: established mechanisms and recent advancements. , 2010, The Surgical clinics of North America.

[16]  S. Batra,et al.  Both TRIF- and MyD88-Dependent Signaling Contribute to Host Defense against Pulmonary Klebsiella Infection1 , 2009, The Journal of Immunology.

[17]  M. Jeschke.  The Hepatic Response to Thermal Injury: Is the Liver Important for Postburn Outcomes? , 2009, Molecular medicine.

[18]  Myung G. Lee,et al.  Effects of endotoxin derived from Escherichia coli lipopolysaccharide on the pharmacokinetics of drugs , 2008, Archives of pharmacal research.

[19]  X. Chen,et al.  Tumor necrosis factor alpha partially contributes to lipopolysaccharide-induced downregulation of CYP3A in fetal liver: its repression by a low dose LPS pretreatment. , 2008, Toxicology letters.

[20]  M. Beaussier,et al.  Hypoxia-induced changes in the expression of rat hepatobiliary transporter genes. , 2007, American journal of physiology. Gastrointestinal and liver physiology.

[21]  J. Ferrières,et al.  Metabolic Endotoxemia Initiates Obesity and Insulin Resistance , 2007, Diabetes.

[22]  M. Negishi,et al.  CAR and PXR: The xenobiotic-sensing receptors , 2007, Steroids.

[23]  Sun-Mee Lee,et al.  Role of nitric oxide in the inhibition of liver cytochrome P450 during sepsis. , 2006, Nitric oxide : biology and chemistry.

[24]  Si Y. Wang,et al.  Effect of Ligustrazine on liver injury after burn trauma. , 2006, Burns : journal of the International Society for Burn Injuries.

[25]  Sun-Mee Lee,et al.  Vitamins C and E protect hepatic cytochrome P450 dysfunction induced by polymicrobial sepsis. , 2006, European journal of pharmacology.

[26]  T. A. Richardson,et al.  EXPRESSION OF UDP-GLUCURONOSYLTRANSFERASE ISOFORM mRNAS DURING INFLAMMATION AND INFECTION IN MOUSE LIVER AND KIDNEY , 2006, Drug Metabolism and Disposition.

[27]  R. Hayes,et al.  Identification and preliminary validation of novel biomarkers of acute hepatic ischaemia/reperfusion injury using dual-platform proteomic/degradomic approaches , 2006, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

[28]  M. Déry,et al.  Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators. , 2005, The international journal of biochemistry & cell biology.

[29]  Sun-Mee Lee,et al.  SUPPRESSION OF HEPATIC CYTOCHROME P450-MEDIATED DRUG METABOLISM DURING THE LATE STAGE OF SEPSIS IN RATS , 2005, Shock.

[30]  K. Feingold,et al.  Suppression of DHEA sulfotransferase (Sult2A1) during the acute-phase response. , 2004, American journal of physiology. Endocrinology and metabolism.

[31]  Sun-Mee Lee,et al.  Effects of Trolox on the activity and gene expression of cytochrome P450 in hepatic ischemia/reperfusion , 2004, British journal of pharmacology.

[32]  R. Gottlieb.  Cytochrome P450: major player in reperfusion injury. , 2003, Archives of biochemistry and biophysics.

[33]  W. Song.  Biochemistry and Reproductive Endocrinology of Estrogen Sulfotransferase , 2001, Annals of the New York Academy of Sciences.

[34]  J. Goldstein,et al.  Clinical relevance of genetic polymorphisms in the human CYP2C subfamily. , 2001, British journal of clinical pharmacology.

[35]  N. Javitt,et al.  Cholesterol and hydroxycholesterol sulfotransferases: identification, distinction from dehydroepiandrosterone sulfotransferase, and differential tissue expression. , 2001, Endocrinology.

[36]  E. Morgan,et al.  Effects of bacterial lipopolysaccharide on phenobarbital-induced CYP2B expression in mice. , 2001, Drug metabolism and disposition: the biological fate of chemicals.

[37]  A. Peitzman,et al.  The Impact of Liver Dysfunction on Outcome in Patients with Multiple Injuries , 2001, The American surgeon.

[38]  X. Li,et al.  Effect of ginsenoside on IL-1 beta and IL-6 mRNA expression in hippocampal neurons in chronic inflammation model of aged rats. , 2000, Acta pharmacologica Sinica.

[39]  C. Deutschman,et al.  Intraabdominal sepsis down-regulates transcription of sodium taurocholate cotransporter and multidrug resistance-associated protein in rats. , 2000, Shock.

[40]  P. Heinrich,et al.  Hepatic cytochrome P450 down‐regulation during aseptic inflammation in the mouse is interleukin 6 dependent , 2000, Hepatology.

[41]  D. Waxman,et al.  P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR. , 1999, Archives of biochemistry and biophysics.

[42]  J. Peters,et al.  Modulation of cytochrome P-450 gene expression in endotoxemic mice is tissue specific and peroxisome proliferator-activated receptor-alpha dependent. , 1999, The Journal of pharmacology and experimental therapeutics.

[43]  P. Ricciardi-Castagnoli,et al.  Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. , 1998, Science.

[44]  I. Chaudry,et al.  A Single Hit Model of Polymicrobial Sepsis: Cecal Ligation and Puncture , 1998 .

[45]  E. Faist,et al.  SYSTEMIC INFLAMMATORY RESPONSE SYNDROME (SIRS), MULTIPLE ORGAN DYSFUNCTION SYNDROME (MODS), MULTIPLE ORGAN FAILURE (MOF): ARE WE WINNING THE BATTLE? , 1998, Shock.

[46]  E. Morgan,et al.  Nitric oxide-independent suppression of P450 2C11 expression by interleukin-1beta and endotoxin in primary rat hepatocytes. , 1997, Biochemical pharmacology.

[47]  O. Khatsenko,et al.  Nitric oxide differentially affects constitutive cytochrome P450 isoforms in rat liver. , 1997, The Journal of pharmacology and experimental therapeutics.

[48]  Slobodan Petar Rendic,et al.  Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors. , 1997, Drug metabolism reviews.

[49]  D. Koop,et al.  Endotoxemia in rats is associated with induction of the P4504A subfamily and suppression of several other forms of cytochrome P450. , 1996, Drug metabolism and disposition: the biological fate of chemicals.

[50]  T. Vales,et al.  Selective suppression of cytochrome P-450 gene expression by interleukins 1 and 6 in rat liver. , 1994, Biochimica et biophysica acta.

[51]  T. Kirikae,et al.  Bacterial endotoxin: molecular relationships of structure to activity and function , 1994, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[52]  L. Corcos,et al.  Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture. , 1993, Molecular pharmacology.

[53]  J. Singer,et al.  A simple multiple system organ failure scoring system predicts mortality of patients who have sepsis syndrome. , 1993, Chest.

[54]  L. Chauvelot‐Moachon,et al.  Effects of interleukin-6 on cytochrome P450-dependent mixed-function oxidases in the rat. , 1992, Biochemical pharmacology.

[55]  R. Weinshilboum,et al.  Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA. , 1992, Molecular pharmacology.

[56]  P. Boekstegers,et al.  Peripheral oxygen availability within skeletal muscle in sepsis and septic shock: Comparison to limited infection and cardiogenic shock , 1991, Infection.

[57]  K. A. Comer,et al.  Human liver steroid sulphotransferase sulphates bile acids. , 1990, The Biochemical journal.

[58]  R. L. Fulton,et al.  Multiple system organ failure. The role of uncontrolled infection. , 1980, Archives of surgery.

[59]  D. Webb.  Animal models of human disease: inflammation. , 2014, Biochemical pharmacology.

[60]  D. Rittirsch,et al.  Immunodesign of experimental sepsis by cecal ligation and puncture , 2008, Nature Protocols.

[61]  S. Asai,et al.  Monitoring expression of cytochrome P450 genes during postischemic rat liver reperfusion using DNA microarrays. , 2005, Journal of pharmacological sciences.

[62]  R. Ulevitch,et al.  Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. , 1995, Annual review of immunology.

[63]  A. Sauaia,et al.  Early predictors of postinjury multiple organ failure. , 1994, Archives of surgery.

[64]  D. Labrecque,et al.  Frequency and characteristics of hyperbilirubinemia associated with bacteremia. , 1985, Reviews of infectious diseases.