Local palmitoylation cycles define activity-regulated postsynaptic subdomains

Local palmitoylation machinery has an instructive role in creating activity-responsive PSD-95 nanodomains, which contribute to postsynaptic density (re)organization.

[1]  Franck Perez,et al.  Synchronization of secretory protein traffic in populations of cells , 2012, Nature Methods.

[2]  R. Huganir,et al.  Palmitoylation by DHHC5/8 Targets GRIP1 to Dendritic Endosomes to Regulate AMPA-R Trafficking , 2012, Neuron.

[3]  G. R. Prescott,et al.  Endoplasmic Reticulum Localization of DHHC Palmitoyltransferases Mediated by Lysine-based Sorting Signals* , 2011, The Journal of Biological Chemistry.

[4]  J. Greaves,et al.  The palmitoyl transferase DHHC2 targets a dynamic membrane cycling pathway: regulation by a C-terminal domain , 2011, Molecular biology of the cell.

[5]  H. Gainer,et al.  PSD-95 Is Required to Sustain the Molecular Organization of the Postsynaptic Density , 2011, The Journal of Neuroscience.

[6]  J. Greaves,et al.  The intracellular dynamic of protein palmitoylation , 2010, The Journal of cell biology.

[7]  X. Zhuang,et al.  Superresolution Imaging of Chemical Synapses in the Brain , 2010, Neuron.

[8]  S. Snyder,et al.  Protein modifications involved in neurotransmitter and gasotransmitter signaling , 2010, Trends in Neurosciences.

[9]  M. Waxham,et al.  Structure and composition of the postsynaptic density during development , 2010, The Journal of comparative neurology.

[10]  J. Rain,et al.  Characterization of single chain antibody targets through yeast two hybrid , 2010, BMC biotechnology.

[11]  S. Tomita,et al.  TARP Phosphorylation Regulates Synaptic AMPA Receptors through Lipid Bilayers , 2010, Neuron.

[12]  M. Fukata,et al.  Protein palmitoylation in neuronal development and synaptic plasticity , 2010, Nature Reviews Neuroscience.

[13]  D. Bredt,et al.  Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95 , 2009, The Journal of cell biology.

[14]  Huilin Li,et al.  The Postsynaptic Density Proteins Homer and Shank Form a Polymeric Network Structure , 2009, Cell.

[15]  S. Dübel,et al.  A multi-Fc-species system for recombinant antibody production , 2009, BMC Biotechnology.

[16]  Suliana Manley,et al.  Photoactivatable mCherry for high-resolution two-color fluorescence microscopy , 2009, Nature Methods.

[17]  Franck Perez,et al.  Detection of GTP-Tubulin Conformation in Vivo Reveals a Role for GTP Remnants in Microtubule Rescues , 2008, Science.

[18]  F. Perez,et al.  Identification of G Protein α Subunit-Palmitoylating Enzyme , 2008, Molecular and Cellular Biology.

[19]  John R. Yates,et al.  Neural Palmitoyl-Proteomics Reveals Dynamic Synaptic Palmitoylation , 2008, Nature.

[20]  Michael D. Ehlers,et al.  Structural plasticity with preserved topology in the postsynaptic protein network , 2008, Proceedings of the National Academy of Sciences.

[21]  Rafael Yuste,et al.  Ultrastructure of Dendritic Spines: Correlation Between Synaptic and Spine Morphologies , 2007, Front. Neurosci..

[22]  D. Saini,et al.  Shuttling of G Protein Subunits between the Plasma Membrane and Intracellular Membranes* , 2007, Journal of Biological Chemistry.

[23]  R. Nicoll,et al.  Synaptic trafficking of glutamate receptors by MAGUK scaffolding proteins. , 2007, Trends in cell biology.

[24]  R. Malinow,et al.  PSD-95 is required for activity-driven synapse stabilization , 2007, Proceedings of the National Academy of Sciences.

[25]  R. Huganir,et al.  Synapse-specific regulation of AMPA receptor function by PSD-95 , 2006, Proceedings of the National Academy of Sciences.

[26]  M. Resh.  Palmitoylation of Ligands, Receptors, and Intracellular Signaling Molecules , 2006, Science's STKE.

[27]  Lars Funke,et al.  Synapse-Specific and Developmentally Regulated Targeting of AMPA Receptors by a Family of MAGUK Scaffolding Proteins , 2006, Neuron.

[28]  Thomas C. Südhof,et al.  Neuroligins Determine Synapse Maturation and Function , 2006, Neuron.

[29]  Shigeo Okabe,et al.  Differential Control of Postsynaptic Density Scaffolds via Actin-Dependent and -Independent Mechanisms , 2006, The Journal of Neuroscience.

[30]  D. Rowlands,et al.  Tagging of NS5A expressed from a functional hepatitis C virus replicon. , 2006, The Journal of general virology.

[31]  Nathan C Shaner,et al.  A guide to choosing fluorescent proteins , 2005, Nature Methods.

[32]  D. Bredt,et al.  Membrane-associated guanylate kinases regulate adhesion and plasticity at cell junctions. , 2005, Annual review of biochemistry.

[33]  Lu Chen,et al.  Postsynaptic assembly induced by neurexin-neuroligin interaction and neurotransmitter , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[34]  Herbert Waldmann,et al.  An Acylation Cycle Regulates Localization and Activity of Palmitoylated Ras Isoforms , 2005, Science.

[35]  P. Scheiffele,et al.  Control of Excitatory and Inhibitory Synapse Formation by Neuroligins , 2005, Science.

[36]  Ann Marie Craig,et al.  Neurexins Induce Differentiation of GABA and Glutamate Postsynaptic Specializations via Neuroligins , 2004, Cell.

[37]  Hillel Adesnik,et al.  Identification of PSD-95 Palmitoylating Enzymes , 2004, Neuron.

[38]  Asher Mullard,et al.  Presynaptic Trafficking of Synaptotagmin I Is Regulated by Protein Palmitoylation* , 2004, Journal of Biological Chemistry.

[39]  M. Sheng,et al.  Quaternary Structure, Protein Dynamics, and Synaptic Function of SAP97 Controlled by L27 Domain Interactions , 2004, Neuron.

[40]  K. Beam,et al.  Metabolic Biotinylation as a Probe of Supramolecular Structure of the Triad Junction in Skeletal Muscle* , 2004, Journal of Biological Chemistry.

[41]  M. Sheng,et al.  PDZ domain proteins of synapses , 2004, Nature Reviews Neuroscience.

[42]  R. Nicoll,et al.  Dynamic Interaction of Stargazin-like TARPs with Cycling AMPA Receptors at Synapses , 2004, Science.

[43]  Xiaobing Chen,et al.  Distribution of Postsynaptic Density (PSD)-95 and Ca2+/Calmodulin-Dependent Protein Kinase II at the PSD , 2003, The Journal of Neuroscience.

[44]  B. Goud,et al.  Recombinant Antibodies Against Subcellular Fractions Used to Track Endogenous Golgi Protein Dynamics in Vivo , 2003, Traffic.

[45]  R. Nicoll,et al.  Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins , 2003, The Journal of cell biology.

[46]  B. Goud,et al.  Recombinant Antibodies to the Small GTPase Rab6 as Conformation Sensors , 2003, Science.

[47]  D. Bredt,et al.  Protein palmitoylation: a regulator of neuronal development and function , 2002, Nature Reviews Neuroscience.

[48]  Neal Sweeney,et al.  Synaptic Strength Regulated by Palmitate Cycling on PSD-95 , 2002, Cell.

[49]  Jacques Noël,et al.  Transient synaptic activation of NMDA receptors leads to the insertion of native AMPA receptors at hippocampal neuronal plasma membranes , 2001, Neuropharmacology.

[50]  R. Weinberg,et al.  Laminar Organization of the NMDA Receptor Complex within the Postsynaptic Density , 2001, The Journal of Neuroscience.

[51]  R. Nicoll,et al.  PSD-95 involvement in maturation of excitatory synapses. , 2000, Science.

[52]  Dane M. Chetkovich,et al.  Dual Palmitoylation of Psd-95 Mediates Its Vesiculotubular Sorting, Postsynaptic Targeting, and Ion Channel Clustering , 2000, The Journal of cell biology.

[53]  R. Nicoll,et al.  Dynamin-dependent endocytosis of ionotropic glutamate receptors. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[54]  D. Bredt,et al.  Synaptic Targeting of the Postsynaptic Density Protein PSD-95 Mediated by Lipid and Protein Motifs , 1999, Neuron.

[55]  Gero Miesenböck,et al.  Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins , 1998, Nature.

[56]  M. Sheng,et al.  Heterogeneity in the Molecular Composition of Excitatory Postsynaptic Sites during Development of Hippocampal Neurons in Culture , 1998, The Journal of Neuroscience.

[57]  D. Bredt,et al.  N-Terminal Palmitoylation of PSD-95 Regulates Association with Cell Membranes and Interaction with K+ Channel Kv1.4 , 1998, Neuron.

[58]  R. Deschenes,et al.  Palmitoylation: policing protein stability and traffic , 2007, Nature Reviews Molecular Cell Biology.