Network regulation in rheumatoid arthritis. Studies of DR+ T cells, anti-DR, antiidiotypic antibodies, and clinical disease activity.

We prospectively studied rheumatoid arthritis patients with various degrees of clinical disease activity, for the presence of DR+ T cells by flow cytometry, for anti-DR using immunoblot analysis, and for antiidiotypic (anti-id) antibodies by enzyme-linked immunosorbent assay using F(ab')2 monoclonal antibody anti-DR L243 as idiotype. DR+ T cells correlated positively with anti-DR, and anti-id correlated negatively with both DR+ T cells and anti-DR. Active clinical disease correlated positively with both DR+ T cells and anti-DR, and correlated negatively with anti-id. This DR antigen/anti-DR/anti-id network may control disease activity in rheumatoid arthritis patients.

[1]  N. Olsen,et al.  High levels of in vitro IgM rheumatoid factor synthesis correlate with HLA-DR4 in normal individuals. , 1987, Arthritis and rheumatism.

[2]  P. Surányi,et al.  Antigen density on the surface of mononuclear cells in SLE. , 1987, Immunology letters.

[3]  E. Reed,et al.  Effect of antiidiotypic antibodies to HLA on graft survival in renal-allograft recipients. , 1987, The New England journal of medicine.

[4]  J. Clot,et al.  Identification of class II HLA alloantibodies in placenta-eluted gamma globulins used for treating rheumatoid arthritis. , 1987, Arthritis and rheumatism.

[5]  R. Searles,et al.  Anti-idiotypic antibodies to anti-DR in patients with rheumatoid arthritis. , 1987, Clinical immunology and immunopathology.

[6]  R. Williams,et al.  Changes in anti-lymphocyte and anti-Ia antibodies during pregnancy in systemic lupus erythematosus. , 1986, Clinical immunology and immunopathology.

[7]  R. Williams,et al.  Studies of anti-F(ab')2 antibodies and possible immunologic control mechanisms in systemic lupus erythematosus. , 1984, Arthritis and rheumatism.

[8]  R. Rossen,et al.  Regulation of antibody release by naturally occurring anti-immunoglobulins in cultures of pokeweed mitogen-stimulated human peripheral blood lymphocytes. , 1984, Journal of immunology.

[9]  S. Meuer,et al.  A monoclonal antibody that blocks class II histocompatibility-related immune interactions. , 1984, Human immunology.

[10]  R. Searles,et al.  Ia specific antilymphocyte antibodies in rheumatoid arthritis. , 1983, Arthritis and rheumatism.

[11]  E. Reed,et al.  Anti-idiotypic antibodies to anti-HLA receptors induced by pregnancy. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[12]  E. Barnett,et al.  Characterization of anti-F(ab')2 antibodies in SLE patients. Evidence for cross-reacting auto-anti-idiotypic antibodies. , 1982, Clinical immunology and immunopathology.

[13]  R. Searles,et al.  Antibodies in the sera of patients with systemic lupus erythematosus that block the binding of monoclonal anti-Ia to Ia-positive targets also inhibit the autologous mixed lymphocyte response. , 1982, Journal of immunology.

[14]  J. Silver,et al.  Biochemical characterization of a second family of human Ia molecules, HLA-DS, equivalent to murine I-A subregion molecules , 1982, The Journal of experimental medicine.

[15]  R. Williams,et al.  Anti-Ia antibody in the sera of normal subjects after in vivo antigenic stimulation , 1982, The Journal of experimental medicine.

[16]  R. Searles,et al.  The presence of Ia antigen on human peripheral blood T cells and T-cell subsets: analysis with monoclonal antibodies and the fluorescence-activated cell sorter. , 1981, Cellular immunology.

[17]  R. Winchester,et al.  Ia+ T cells in synovial fluid and tissues of patients with rheumatoid arthritis. , 1981, Arthritis and rheumatism.

[18]  D. Mitchell,et al.  Preliminary criteria for clinical remission in rheumatoid arthritis. , 1981, Arthritis and rheumatism.

[19]  N. Abdou,et al.  Network theory in autoimmunity. In vitro suppression of serum anti-DNA antibody binding to DNA by anti-idiotypic antibody in systemic lupus erythematosus. , 1981, The Journal of clinical investigation.

[20]  D. Carson,et al.  Inheritance of immunoglobulin M rheumatoid-factor idiotypes. , 1980, The Journal of clinical investigation.

[21]  H. Mcdevitt,et al.  Increased frequency of HLA-Cw3 and HLA-Dw4 in rheumatoid arthritis. , 1977, Arthritis and rheumatism.

[22]  Elizabeth Simpson,et al.  A rapid method for the isolation of functional thymus‐derived murine lymphocytes , 1973, European journal of immunology.

[23]  J. J. Bunim,et al.  ARA NOMENCLATURE AND CLASSIFICATION OF ARTHRITIS AND RHEUMATISM (TENTATIVE). , 1964, Arthritis and rheumatism.

[24]  R. Williams,et al.  In vitro inhibition of anti-DNA producing cells from systemic lupus erythematosus patients by autologous anti-F(ab')2 antibodies. , 1987, Clinical immunology and immunopathology.

[25]  J. Yodoi,et al.  Systemic lupus erythematosus sera antilymphocyte reactivity: detection of antibodies to Tac-antigen positive T cell lines. , 1986, Clinical and experimental immunology.

[26]  R. Tosi,et al.  Anti-Ia reactivity in sera of untreated patients with active Hodgkin's disease. , 1985, Clinical immunology and immunopathology.

[27]  A. Yamada,et al.  Surface antigen specificity of cold-reactive IgM antilymphocyte antibodies in systemic lupus erythematosus. , 1985, Arthritis and rheumatism.

[28]  J. Clot,et al.  Immunomodulating effect of human placenta-eluted gamma globulins in rheumatoid arthritis. , 1982, Arthritis and rheumatism.

[29]  R. Williams,et al.  Anti-Ia reactivity in sera from patients with systemic lupus erythematosus. , 1982, The Journal of clinical investigation.