Abstract Scientific progress in the area of machine learning, in particular advances in deep learning, have led to an increase in interest in eScience and related fields. While such methods achieve great results, an in-depth understanding of these new technologies and concepts is still often lacking and domain knowledge and subject matter expertise play an important role. In regard to space science there are a vast variety of application areas, in particular with regard to analysis of observational data. This chapter aims at introducing a number of promising approaches to analyze time series data, via the introduction query by example, i.e., any signal can be provided to the system, which then responds with a ranked list of datasets containing similar signals. Building on top of this ability the system can then be trained using annotations provided by expert users, with the goal of detecting similar features and hence provide a semiautomated analysis and classification. A prototype built to work on MESSENGER data based on existing background implementations by the Know-Center in cooperation with the Space Research Institute in Graz is presented. Further, several representations of time series data that demonstrated to be required for analysis tasks, as well as techniques for preprocessing, frequent pattern mining, outlier detection, and classification of segmented and unsegmented data, are discussed. Screen shots of the developed prototype, detailing various techniques for the presentation of signals, complete the discussion.