The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics

[1]  J. Schneider,et al.  Autophagy and Metabolism , 2016 .

[2]  K. Tracey,et al.  Tanshinone IIA sodium sulfonate facilitates endocytic HMGB1 uptake. , 2012, Biochemical pharmacology.

[3]  A. Krasinskas,et al.  The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia , 2012, Proceedings of the National Academy of Sciences.

[4]  Simon C Watkins,et al.  p53/HMGB1 complexes regulate autophagy and apoptosis. , 2012, Cancer research.

[5]  A. Schmidt,et al.  Signal transduction in receptor for advanced glycation end products (RAGE). SOLUTION STRUCTURE OF C-TERMINAL RAGE (ctRAGE) AND ITS BINDING TO mDia1. , 2012, Journal of Biological Chemistry.

[6]  R. Kang RAGE Expression is Permissive for Early Pancreatic Neoplasia , 2012 .

[7]  M. Lotze,et al.  The Receptor for Advanced Glycation End-products (RAGE) protects pancreatic tumor cells against oxidative injury. , 2011, Antioxidants & redox signaling.

[8]  G. Kroemer,et al.  High-mobility group box 1 is essential for mitochondrial quality control. , 2011, Cell metabolism.

[9]  K. Tracey,et al.  HMGB1 is a therapeutic target for sterile inflammation and infection. , 2011, Annual review of immunology.

[10]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[11]  K. Tracey,et al.  Endogenous HMGB1 regulates autophagy , 2010, The Journal of cell biology.

[12]  K. Tracey,et al.  HMGB1 Release and Redox Regulates Autophagy and Apoptosis in Cancer Cells , 2010, Oncogene.

[13]  J. Poderoso,et al.  Mitochondrial kinases in cell signaling: Facts and perspectives. , 2009, Advanced drug delivery reviews.

[14]  L. Opitz,et al.  A New Paradigm for MAPK: Structural Interactions of hERK1 with Mitochondria in HeLa Cells , 2009, PloS one.

[15]  M. Lotze,et al.  The Receptor for Advanced Glycation End-products (RAGE) Sustains Autophagy and Limits Apoptosis, Promoting Pancreatic Tumor Cell Survival , 2009, Cell Death and Differentiation.

[16]  M. Bianchi,et al.  HMGB1 loves company , 2009, Journal of leukocyte biology.

[17]  L. Cantley,et al.  Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation , 2009, Science.

[18]  M. Fink,et al.  Comparison of distinct protein isoforms of the receptor for advanced glycation end-products expressed in murine tissues and cell lines , 2009, Cell and Tissue Research.

[19]  Herbert J Zeh,et al.  Journal of Translational Medicine BioMed Central Review , 2009 .

[20]  P. Fawcett,et al.  Function of Mitochondrial Stat3 in Cellular Respiration , 2009, Science.

[21]  V. D’Agati,et al.  Interaction of the RAGE Cytoplasmic Domain with Diaphanous-1 Is Required for Ligand-stimulated Cellular Migration through Activation of Rac1 and Cdc42* , 2008, Journal of Biological Chemistry.

[22]  D. Sabatini,et al.  Cancer Cell Metabolism: Warburg and Beyond , 2008, Cell.

[23]  A. Enk,et al.  RAGE signaling sustains inflammation and promotes tumor development , 2008, The Journal of experimental medicine.

[24]  L. Porto,et al.  Mitochondrial localization of non‐histone protein HMGB1 during human endothelial cell–Toxoplasma gondii infection , 2008, Cell biology international.

[25]  S. Galli,et al.  A Mitochondrial Kinase Complex Is Essential to Mediate an ERK1/2-Dependent Phosphorylation of a Key Regulatory Protein in Steroid Biosynthesis , 2008, PloS one.

[26]  E. Chavakis,et al.  A novel pathway of HMGB1‐mediated inflammatory cell recruitment that requires Mac‐1‐integrin , 2007, The EMBO journal.

[27]  M. Manjili,et al.  Comment on “Tumor Progression Can Occur despite the Induction of Very High Levels of Self/Tumor Antigen-Specific CD8+ T Cells in Patients with Melanoma” , 2006, The Journal of Immunology.

[28]  Kevin J. Tracey,et al.  High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal , 2005, Nature Reviews Immunology.

[29]  Michael T. Lotze,et al.  Inflammation and necrosis promote tumour growth , 2004, Nature Reviews Immunology.

[30]  E. Schleicher,et al.  Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response. , 2004, The Journal of clinical investigation.

[31]  M. Bianchi,et al.  Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation , 2004, The Journal of cell biology.

[32]  J. Medina,et al.  Mitochondrial extracellular signal‐regulated kinases 1/2 (ERK1/2) are modulated during brain development , 2004, Journal of neurochemistry.

[33]  Suwei Wang,et al.  Activation of nuclear factor-kappaB during doxorubicin-induced apoptosis in endothelial cells and myocytes is pro-apoptotic: the role of hydrogen peroxide. , 2002, The Biochemical journal.

[34]  K. Tracey,et al.  Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[35]  T. Misteli,et al.  Release of chromatin protein HMGB1 by necrotic cells triggers inflammation , 2002, Nature.

[36]  A. Schmidt,et al.  The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses. , 2001, The Journal of clinical investigation.

[37]  A. Aguzzi,et al.  The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice , 1999, Nature Genetics.

[38]  R. Gerard,et al.  Reduction of tumor cell migration and metastasis by adenoviral gene transfer of plasminogen activator inhibitors , 1999, Gene Therapy.

[39]  D. Tang,et al.  HMGB1 promotes drug resistance in osteosarcoma. , 2012, Cancer research.

[40]  L. Cantley,et al.  Cancer Cell Metabolism , 2012 .

[41]  Y. Zou,et al.  RAGE Gene Deletion Inhibits the Development and Progression of Ductal Neoplasia and Prolongs Survival in a Murine Model of Pancreatic Cancer , 2011, Journal of Gastrointestinal Surgery.

[42]  Herbert J Zeh,et al.  High-mobility group box 1 and cancer. , 2010, Biochimica et biophysica acta.

[43]  A. Mantovani,et al.  Cancer: Inflaming metastasis , 2008, Nature.

[44]  J. Dixon,et al.  Mitochondrial modulation: reversible phosphorylation takes center stage? , 2006, Trends in biochemical sciences.