Microfluidic‐Assisted Self‐Assembly of Complex Dendritic Polyethylene Drug Delivery Nanocapsules

Microfluidic platform for the synthesis of complex nanocapsules is presented via a controlled self-assembly. The monodisperse nanocapsules in the range of 50-200 nm consist of a dendritic polyethylene core and a Pluronic copolymer shell. The resultant nanocarriers encapsulate large amount of hydrophobic anticancer drug like paclitaxel while providing a low complement activation as well as sustained release profile with high tunability.

[1]  Piet Gros,et al.  Structure of C3b reveals conformational changes that underlie complement activity , 2006, Nature.

[2]  S. Moein Moghimi,et al.  Nanomedicine and the complement paradigm. , 2013, Nanomedicine : nanotechnology, biology, and medicine.

[3]  Robert Langer,et al.  Microfluidic technologies for accelerating the clinical translation of nanoparticles. , 2012, Nature nanotechnology.

[4]  Ashutosh Chilkoti,et al.  Nanomaterials for Drug Delivery , 2012, Science.

[5]  Mohammad Mahdi Hasani-Sadrabadi,et al.  Microfluidic synthesis of chitosan-based nanoparticles for fuel cell applications. , 2012, Chemical communications.

[6]  R. Duncan,et al.  Dendrimer biocompatibility and toxicity. , 2005, Advanced drug delivery reviews.

[7]  Erfan Dashtimoghadam,et al.  Microfluidic self-assembly of polymeric nanoparticles with tunable compactness for controlled drug delivery , 2013 .

[8]  Z. Guan,et al.  Tandem chain walking polymerization and atom transfer radical polymerization for efficient synthesis of dendritic nanoparticles for bioconjugation. , 2006, Journal of the American Chemical Society.

[9]  Wyatt N Vreeland,et al.  Microfluidic directed formation of liposomes of controlled size. , 2007, Langmuir : the ACS journal of surfaces and colloids.

[10]  Zhilong Hu,et al.  Synthesis of amphiphilic copolymers with a dendritic polyethylene core and poly(ethylene oxide) arms and their self-assembled nanostructures , 2013 .

[11]  O. Ikkala,et al.  Functional Materials Based on Self-Assembly of Polymeric Supramolecules , 2002, Science.

[12]  Davoud Ahmadvand,et al.  Material properties in complement activation. , 2011, Advanced drug delivery reviews.

[13]  R. Zengerle,et al.  Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications. , 2010, Chemical Society reviews.

[14]  Kinam Park,et al.  Hydrotropic polymer micelle system for delivery of paclitaxel. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[15]  Mohammad Mahdi Hasani-Sadrabadi,et al.  Microfluidic assisted self-assembly of chitosan based nanoparticles as drug delivery agents. , 2013, Lab on a chip.

[16]  Wei Zhang,et al.  Paclitaxel-loaded micelles composed of folate-poly(ethylene glycol) and poly(γ-benzyl l-glutamate) diblock copolymer , 2010 .

[17]  R. Haag,et al.  Tandem Coordination, Ring-Opening, Hyperbranched Polymerization for the Synthesis of Water-Soluble Core-Shell Unimolecular Transporters. , 2012, ACS macro letters.

[18]  Maurice Brookhart,et al.  New Pd(II)- and Ni(II)-Based Catalysts for Polymerization of Ethylene and .alpha.-Olefins , 1995 .

[19]  Anil K Patri,et al.  Dendritic polymer macromolecular carriers for drug delivery. , 2002, Current opinion in chemical biology.

[20]  P. Renaud,et al.  Morphological tuning of polymeric nanoparticles via microfluidic platform for fuel cell applications. , 2012, Journal of the American Chemical Society.

[21]  Mauro Ferrari,et al.  Nanomedicine--challenge and perspectives. , 2009, Angewandte Chemie.

[22]  K. Jacob,et al.  A microfluidic approach to synthesizing high-performance microfibers with tunable anhydrous proton conductivity. , 2013, Lab on a chip.

[23]  G. Whitesides The origins and the future of microfluidics , 2006, Nature.

[24]  M. Dobrovolskaia,et al.  Immunological properties of engineered nanomaterials , 2007, Nature Nanotechnology.

[25]  V. Torchilin,et al.  Palmitoyl ascorbate-modified liposomes as nanoparticle platform for ascorbate-mediated cytotoxicity and paclitaxel co-delivery. , 2010, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[26]  B. Vincent,et al.  Controlled release of 4-nitroanisole from poly(lactic acid) nanoparticles. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[27]  Z. Guan Recent progress of catalytic polymerization for controlling polymer topology. , 2010, Chemistry, an Asian journal.

[28]  Robert Langer,et al.  Microfluidic platform for controlled synthesis of polymeric nanoparticles. , 2008, Nano letters.

[29]  R. Schwartz Paul Ehrlich's magic bullets. , 2004, The New England journal of medicine.

[30]  S. Mecking,et al.  Mechanistic Studies of the Palladium-Catalyzed Copolymerization of Ethylene and α-Olefins with Methyl Acrylate , 1998 .

[31]  Wyatt N Vreeland,et al.  Microfluidic mixing and the formation of nanoscale lipid vesicles. , 2010, ACS nano.

[32]  Yongfeng Zhou,et al.  Influence of branching architecture on polymer properties , 2011 .

[33]  Thomas Vorup-Jensen,et al.  Curvature of Synthetic and Natural Surfaces Is an Important Target Feature in Classical Pathway Complement Activation , 2010, The Journal of Immunology.

[34]  Daniel A. Heller,et al.  Treating metastatic cancer with nanotechnology , 2011, Nature Reviews Cancer.

[35]  Omid C Farokhzad,et al.  Targeted polymeric therapeutic nanoparticles: design, development and clinical translation. , 2012, Chemical Society reviews.

[36]  M. Gijs,et al.  Controlled synthesis of fluorescent silica nanoparticles inside microfluidic droplets. , 2012, Lab on a chip.

[37]  Yanbin Fan,et al.  The intranuclear release of a potential anticancer drug from small nanoparticles that are derived from intracellular dissociation of large nanoparticles. , 2012, Biomaterials.

[38]  Z. Guan,et al.  Efficient catalytic synthesis of dendritic polymers having internal fluorescence labels for bioconjugation. , 2008, Biomacromolecules.

[39]  Tongwen Xu,et al.  Design of biocompatible dendrimers for cancer diagnosis and therapy: current status and future perspectives. , 2011, Chemical Society reviews.

[40]  Kinam Park,et al.  A new hydrotropic block copolymer micelle system for aqueous solubilization of paclitaxel. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[41]  Renjith P. Johnson,et al.  Biocompatible Poly(2‐hydroxyethyl methacrylate)‐b‐poly(L‐histidine) Hybrid Materials for pH‐Sensitive Intracellular Anticancer Drug Delivery , 2012 .

[42]  Z. Guan,et al.  Cascade Chain-Walking Polymerization to Generate Large Dendritic Nanoparticles , 2010 .

[43]  Johnson V. John,et al.  Dual stimuli-responsive poly(N-isopropylacrylamide)-b-poly(L-histidine) chimeric materials for the controlled delivery of doxorubicin into liver carcinoma. , 2013, Biomacromolecules.

[44]  Zhibin Ye,et al.  Hyperbranched polyethylenes by chain walking polymerization: synthesis, properties, functionalization, and applications , 2012 .

[45]  S M Moghimi,et al.  Long-circulating and target-specific nanoparticles: theory to practice. , 2001, Pharmacological reviews.

[46]  McLain,et al.  Chain walking: A new strategy to control polymer topology , 1999, Science.