Extrarenal perivascular epithelioid cell tumors (PEComas) respond to mTOR inhibition: Clinical and molecular correlates
暂无分享,去创建一个
[1] P. Argani,et al. Perivascular epithelioid cell tumors (PEComas) harboring TFE3 gene rearrangements lack the TSC2 alterations characteristic of conventional PEComas: further evidence for a biological distinction. , 2012, The American journal of surgical pathology.
[2] L. Macconaill,et al. Angiomyolipoma Have Common Mutations in TSC2 but No Other Common Genetic Events , 2011, PloS one.
[3] J. Manola,et al. Multicenter Phase 2 Trial of Sirolimus for Tuberous Sclerosis: Kidney Angiomyolipomas and Other Tumors Regress and VEGF- D Levels Decrease , 2011, PloS one.
[4] M. Rubin,et al. Validation of a TFE3 Break-apart FISH Assay for Xp11.2 Translocation Renal Cell Carcinomas , 2011, Diagnostic molecular pathology : the American journal of surgical pathology, part B.
[5] C. Burger. Efficacy and safety of sirolimus in lymphangioleiomyomatosis. , 2011, The New England journal of medicine.
[6] K. Pointon,et al. Sirolimus Therapy for Angiomyolipoma in Tuberous Sclerosis and Sporadic Lymphangioleiomyomatosis: A Phase 2 Trial , 2011, Clinical Cancer Research.
[7] J. Blay. Updating progress in sarcoma therapy with mTOR inhibitors. , 2011, Annals of oncology : official journal of the European Society for Medical Oncology.
[8] D. Sabatini,et al. mTOR: from growth signal integration to cancer, diabetes and ageing , 2010, Nature Reviews Molecular Cell Biology.
[9] J. Manola,et al. Combination mTOR and IGF-1R Inhibition: Phase I Trial of Everolimus and Figitumumab in Patients with Advanced Sarcomas and Other Solid Tumors , 2010, Clinical Cancer Research.
[10] M. Ladanyi,et al. A Distinctive Subset of PEComas Harbors TFE3 Gene Fusions , 2010, The American journal of surgical pathology.
[11] R. Kurzrock,et al. Resistance to mammalian target of rapamycin inhibitor therapy in perivascular epithelioid cell tumors. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[12] B. Bui,et al. Treatment with the mTOR inhibitor temsirolimus in patients with malignant PEComa. , 2010, Annals of oncology : official journal of the European Society for Medical Oncology.
[13] D. Kwiatkowski,et al. Tuberous Sclerosis Complex: Genes, Clinical Features and Therapeutics , 2010 .
[14] C. Antonescu,et al. Clinical activity of mTOR inhibition with sirolimus in malignant perivascular epithelioid cell tumors: targeting the pathogenic activation of mTORC1 in tumors. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[15] A. Folpe,et al. Perivascular epithelioid cell neoplasms: pathology and pathogenesis. , 2010, Human pathology.
[16] H. Lane,et al. Equivalent benefit of mTORC1 blockade and combined PI3K-mTOR blockade in a mouse model of tuberous sclerosis , 2009, Molecular Cancer.
[17] D. Guertin,et al. The Pharmacology of mTOR Inhibition , 2009, Science Signaling.
[18] C. Pan,et al. Constant allelic alteration on chromosome 16p (TSC2 gene) in perivascular epithelioid cell tumour (PEComa): genetic evidence for the relationship of PEComa with angiomyolipoma , 2008, The Journal of pathology.
[19] Vincent J Schmithorst,et al. Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. , 2008, The New England journal of medicine.
[20] G. Zamboni,et al. PEComas: the past, the present and the future , 2007, Virchows Archiv.
[21] A. Folpe,et al. Activation of the mTOR pathway in sporadic angiomyolipomas and other perivascular epithelioid cell neoplasms. , 2007, Human pathology.
[22] P. Crino,et al. The tuberous sclerosis complex. , 2006, The New England journal of medicine.
[23] Hongbing Zhang,et al. Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin. , 2003, Cancer research.
[24] Hongbing Zhang,et al. Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma , 2003, The Lancet.
[25] L. Aicher,et al. Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors. , 2002, Cancer research.
[26] E. Henske,et al. Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[27] B. Scheithauer,et al. Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of tuberous sclerosis tumors. , 1997, The American journal of pathology.