论文信息 - Asymmetric Synthesis of Two Hydroxylated Pyrrolizidines From a C-Allyl Epoxypyrrolidine

Asymmetric Synthesis of Two Hydroxylated Pyrrolizidines From a C-Allyl Epoxypyrrolidine

Abstract The efficient two-step preparation of a new pivotal C-allyl epoxypyrrolidine intermediate from an enantio-enriched epoxyaldehyde precursor is described. The synthetic potential of this building block is demonstrated with the first enantioselective synthesis of two hydroxylated pyrrolizidine relying on a regio- and stereocontrolled epoxide opening reaction. GRAPHICAL ABSTRACT

Y. Génisson | Cécile Baudoin-Dehoux | Tessa Castellan | Emiliano Zapata-Machin

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