Bilateral proliferative retinopathy in B-cell acute lymphoblastic leukemia

A 4-year-old child with B-cell acute lymphoblastic leukemia presented with vitreous hemorrhage due to proliferative retinopathy in both eyes. Pars plana vitrectomy was performed in both eyes to clear nonresolving vitreous hemorrhage after systemic stabilization. Visual recovery was limited by the disc drag in the right eye and subfoveal exudation in the left eye. Etiopathogenesis and management of proliferative retinopathy in acute leukemias are discussed.

[1]  Katherine E. Talcott,et al.  Ophthalmic manifestations of leukemia , 2016, Current opinion in ophthalmology.

[2]  Tomomi Metoki,et al.  A Case of Childhood Vitrectomy Performed for Dense Vitreous Hemorrhage Secondary to Leukemia Therapy and Tumor Lysis Syndrome , 2015, Case Reports in Ophthalmology.

[3]  Miguel Gomes,et al.  Bilateral Proliferative Retinopathy as the Initial Presentation of Chronic Myeloid Leukemia , 2013, Middle East African journal of ophthalmology.

[4]  J. Chhablani,et al.  Vitreous hemorrhage in children and adolescents in India. , 2013, Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus.

[5]  Deborah M. Costakos,et al.  Chronic myelogenous leukemia manifested as bilateral proliferative retinopathy. , 2005, Archives of ophthalmology.

[6]  B. J. Klevering,et al.  Peripheral retinal nonperfusion associated with chronic myeloid leukemia. , 2003, American journal of ophthalmology.

[7]  A. Levy,et al.  OCCLUSIVE MICROVASCULAR RETINOPATHY WITH OPTIC DISC AND RETINAL NEOVASCULARIZATION IN ACUTE LYMPHOCYTIC LEUKEMIA , 1994, Retina.

[8]  E. de Juan,et al.  OPTIC DISC NEOVASCULARIZATION ASSOCIATED WITH OCULAR INVOLVEMENT IN ACUTE LYMPHOCYTIC LEUKEMIA , 1982, Retina.

[9]  R. Frank,et al.  Peripheral retinal neovascularization with chronic myelogenous leukemia. , 1972, Archives of ophthalmology.

[10]  T. Kuwabara LEUKEMIC MILIARY NODULES IN THE RETINA. , 1964, Archives of ophthalmology.