Requires a Second Signal Mediated by Stat6 CD4+CD25+Foxp3+ Regulatory T Cells Agonist-Driven Development of

FreitasO'Malley, Mark H. Kaplan, Sylvie Garcia and Antonio A. Vanesa Sanchez-Guajardo, Corinne Tanchot, John T.http://www.jimmunol.org/content/178/12/7550J Immunol€2007; 178:7550-7556; ;Referenceshttp://www.jimmunol.org/content/178/12/7550.full#ref-list-1This article cites 47 articles, 20 of which you can access for free at: Subscriptionshttp://jimmunol.org/subscriptionsInformation about subscribing to The Journal of Immunology is online at: Permissionshttp://www.aai.org/ji/copyright.htmlSubmit copyright permission requests at: Email Alertshttp://jimmunol.org/cgi/alerts/etocReceive free email-alerts when new articles cite this article. Sign up at:

[1]  S. Akira,et al.  Essential role of Stat6 in IL-4 signalling , 1996, Nature.

[2]  L. Klein,et al.  Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling , 2005, Nature Immunology.

[3]  S. Akira,et al.  STAT6 deficiency inhibits tubulointerstitial fibrosis in obstructive nephropathy. , 2005, International journal of molecular medicine.

[4]  A. Freitas,et al.  Homeostasis of Peripheral CD4+ T Cells: IL-2Rα and IL-2 Shape a Population of Regulatory Cells That Controls CD4+ T Cell Numbers1 , 2002, The Journal of Immunology.

[5]  Antonio A. Freitas,et al.  Indexation as a Novel Mechanism of Lymphocyte Homeostasis: The Number of CD4+CD25+ Regulatory T Cells Is Indexed to the Number of IL-2-Producing Cells1 , 2006, The Journal of Immunology.

[6]  Mark S. Anderson,et al.  The NOD mouse: a model of immune dysregulation. , 2005, Annual review of immunology.

[7]  Shimon Sakaguchi,et al.  Homeostatic maintenance of natural Foxp3 + CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization , 2005, The Journal of experimental medicine.

[8]  T. Malek,et al.  Selective Availability of IL-2 Is a Major Determinant Controlling the Production of CD4+CD25+Foxp3+ T Regulatory Cells1 , 2006, The Journal of Immunology.

[9]  F. Finkelman,et al.  Differential Contribution of IL-4 and STAT6 vs STAT4 to the Development of Lupus Nephritis1 , 2003, The Journal of Immunology.

[10]  M. Milani,et al.  The Susceptibility to Experimental Myasthenia Gravis of STAT6−/− and STAT4−/− BALB/c Mice Suggests a Pathogenic Role of Th1 Cells 1 , 2004, The Journal of Immunology.

[11]  M. Kaplan.  STAT4: a critical regulator of inflammation in vivo. , 2005, Immunologic research.

[12]  I. Horak,et al.  Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting , 1991, Nature.

[13]  A. Rudensky,et al.  Foxp3 programs the development and function of CD4+CD25+ regulatory T cells , 2003, Nature Immunology.

[14]  L. Klein,et al.  Origin of regulatory T cells with known specificity for antigen , 2002, Nature Immunology.

[15]  H. Kiyono,et al.  Development of colitis in signal transducers and activators of transcription 6-deficient T-cell receptor alpha-deficient mice: a potential role of signal transducers and activators of transcription 6-independent interleukin-4 signaling for the generation of Th2-biased pathological CD4+ betabetaT cel , 2003, The American journal of pathology.

[16]  M. Farrar,et al.  IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells1 , 2007, The Journal of Immunology.

[17]  J. Fung,et al.  Mechanistic Insights into Impaired Dendritic Cell Function by Rapamycin: Inhibition of Jak2/Stat4 Signaling Pathway1 , 2004, The Journal of Immunology.

[18]  Nonredundant roles for Stat5a/b in directly regulating Foxp3. , 2007, Blood.

[19]  W. Paul,et al.  Stat5 activation plays a critical role in Th2 differentiation. , 2003, Immunity.

[20]  M. Kaplan,et al.  Stat Proteins Control Lymphocyte Proliferation by Regulating p27Kip1 Expression , 1998, Molecular and Cellular Biology.

[21]  M. Kaplan,et al.  Expression of a Constitutively Active Stat6 In Vivo Alters Lymphocyte Homeostasis with Distinct Effects in T and B Cells1 , 2003, The Journal of Immunology.

[22]  F. Uckun,et al.  Effect of targeted disruption of signal transducer and activator of transcription (Stat)4 and Stat6 genes on the autoimmune diabetes development induced by multiple low doses of streptozotocin. , 2005, Clinical immunology.

[23]  J. Petersen,et al.  Autoreactive CD4+ T cells protect from autoimmune diabetes via bystander suppression using the IL-4/Stat6 pathway. , 1999, Immunity.

[24]  P. Rutgeerts,et al.  Effects of interleukin 4 on CD25+CD4+ regulatory T cell function. , 2005, Journal of autoimmunity.

[25]  J. Ritz,et al.  IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. , 2006, Blood.

[26]  R. Schwartz,et al.  CD4+ and CD8+ T cells acquire specific lymphokine secretion potentials during thymic maturation , 1991, Nature.

[27]  M. Goldsmith,et al.  Loss of Tolerance and Autoimmunity Affecting Multiple Organs in STAT5A/5B-Deficient Mice 1 , 2003, The Journal of Immunology.

[28]  K. Nadeau,et al.  Cutting Edge: Decreased Accumulation and Regulatory Function of CD4+CD25high T Cells in Human STAT5b Deficiency1 , 2006, The Journal of Immunology.

[29]  M. Kaplan,et al.  Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice , 1996, Nature.

[30]  T. Malek,et al.  CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. , 2002, Immunity.

[31]  H. Weiner,et al.  Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells , 2006, Nature.

[32]  Ian A. White,et al.  An IL-4-independent and CD25-mediated function of c-maf in promoting the production of Th2 cytokines , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[33]  H. Lee,et al.  Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells. , 1999, Immunity.

[34]  J. Borghans,et al.  Different Competitive Capacities of Stat4- and Stat6-Deficient CD4+ T Cells during Lymphophenia-Driven Proliferation1 , 2005, The Journal of Immunology.

[35]  S. Pai,et al.  Critical roles for transcription factor GATA-3 in thymocyte development. , 2003, Immunity.

[36]  M. Azuma,et al.  Stat6 activation and Th2 cell proliferation driven by CD28 signals , 2000 .

[37]  Minoru Satoh,et al.  Pivotal Role of Stat4 and Stat6 in the Pathogenesis of the Lupus-Like Disease in the New Zealand Mixed 2328 Mice 1 , 2003, The Journal of Immunology.

[38]  W. Paul,et al.  Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis , 1995, Molecular and cellular biology.

[39]  J. Bluestone,et al.  B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. , 2000, Immunity.

[40]  F. Ramsdell,et al.  An essential role for Scurfin in CD4+CD25+ T regulatory cells , 2003, Nature Immunology.

[41]  A. Naji,et al.  Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide , 2001, Nature Immunology.

[42]  Vincent C. Manganiello,et al.  Foxp3-dependent programme of regulatory T-cell differentiation , 2007, Nature.

[43]  S. Sakaguchi.  Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self , 2005, Nature Immunology.

[44]  C. Bona,et al.  Conditions That Induce Tolerance in Mature CD4+ T Cells , 1997, The Journal of experimental medicine.

[45]  A. Rudensky,et al.  A function for interleukin 2 in Foxp3-expressing regulatory T cells , 2005, Nature Immunology.

[46]  M. Kaplan,et al.  Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. , 1996, Immunity.