Quantitative Analysis of Lung Ultrasonography for the Detection of Community-Acquired Pneumonia: A Pilot Study

Background and Objective. Chest X-ray is recommended for routine use in patients with suspected pneumonia, but its use in emergency settings is limited. In this study, the diagnostic performance of a new method for quantitative analysis of lung ultrasonography was compared with bedside chest X-ray and visual lung ultrasonography for detection of community-acquired pneumonia, using thoracic computed tomography as a gold standard. Methods. Thirty-two spontaneously breathing patients with suspected community-acquired pneumonia, undergoing computed tomography examination, were consecutively enrolled. Each hemithorax was evaluated for the presence or absence of abnormalities by chest X-ray and quantitative or visual ultrasonography. Results. Quantitative ultrasonography showed higher sensitivity (93%), specificity (95%), and diagnostic accuracy (94%) than chest X-ray (64%, 80%, and 69%, resp.), visual ultrasonography (68%, 95%, and 77%, resp.), or their combination (77%, 75%, and 77%, resp.). Conclusions. Quantitative lung ultrasonography was considerably more accurate than either chest X-ray or visual ultrasonography in the diagnosis of community-acquired pneumonia and it may represent a useful first-line approach for confirmation of clinical diagnosis in emergency settings.

[1]  T. Schacker,et al.  Clinical and Epidemiologic Features of Primary HIV Infection , 1996, Annals of Internal Medicine.

[2]  H. Hoyer,et al.  Lung ultrasound in the diagnosis and follow-up of community-acquired pneumonia: a prospective, multicenter, diagnostic accuracy study. , 2012, Chest.

[3]  A. Reissig,et al.  The role of lung ultrasound in the diagnosis and follow-up of community-acquired pneumonia. , 2012, European journal of internal medicine.

[4]  J. Bartlett,et al.  Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in Adults , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[5]  Kunio Doi,et al.  Computer-aided diagnosis in medical imaging: Historical review, current status and future potential , 2007, Comput. Medical Imaging Graph..

[6]  S. Stevens,et al.  Radiation and chest CT scan examinations: what do we know? , 2012, Chest.

[7]  J. Austin,et al.  Glossary of terms for CT of the lungs: recommendations of the Nomenclature Committee of the Fleischner Society. , 1996, Radiology.

[8]  A. Sargsyan,et al.  International evidence-based recommendations for point-of-care lung ultrasound , 2012, Intensive Care Medicine.

[9]  Jacob Cohen A Coefficient of Agreement for Nominal Scales , 1960 .

[10]  Gerhard Osius,et al.  Normal Goodness-of-Fit Tests for Multinomial Models with Large Degrees of Freedom , 1992 .

[11]  D. Lichtenstein,et al.  Ultrasound diagnosis of alveolar consolidation in the critically ill , 2004, Intensive Care Medicine.

[12]  Stefano Di Bartolomeo,et al.  Evaluation of lung ultrasound for the diagnosis of pneumonia in the ED. , 2009, The American journal of emergency medicine.

[13]  Michael J Pentecost,et al.  American College of Radiology white paper on radiation dose in medicine. , 2007, Journal of the American College of Radiology : JACR.

[14]  T. Schaberg,et al.  Guidelines for the management of adult lower respiratory tract infections ‐ Full version , 2011, Clinical Microbiology and Infection.

[15]  J. R. Landis,et al.  The measurement of observer agreement for categorical data. , 1977, Biometrics.

[16]  I. Bolíbar,et al.  Epidemiology of community-acquired pneumonia in adults: a population-based study. , 2000, The European respiratory journal.

[17]  C A Britton,et al.  Interobserver reliability of the chest radiograph in community-acquired pneumonia. PORT Investigators. , 1996, Chest.

[18]  T. Schaberg,et al.  Guidelines for the management of adult lower respiratory tract infections--summary. , 2011, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[19]  J. Riancho,et al.  CURB-65 as an initial prognostic score in Internal Medicine patients. , 2013, European journal of internal medicine.

[20]  M. Copetti,et al.  Clinical application of transthoracic ultrasonography in inpatients with pneumonia , 2011, European journal of clinical investigation.

[21]  Interobserver reliability of radiologists' interpretations of mobile chest radiographs for nursing home-acquired pneumonia. , 2006, Journal of the American Medical Directors Association.

[22]  M. A. Chavez,et al.  Lung ultrasound for the diagnosis of pneumonia in adults: a systematic review and meta-analysis , 2014, Respiratory Research.

[23]  A. Reissig,et al.  Sonographic Diagnosis and Follow-Up of Pneumonia: A Prospective Study , 2007, Respiration.

[24]  W. Lim,et al.  Severity prediction rules in community acquired pneumonia: a validation study , 2000, Thorax.

[25]  M. Fine,et al.  Guidelines for the management of adults with community-acquired pneumonia. Diagnosis, assessment of severity, antimicrobial therapy, and prevention. , 2001, American journal of respiratory and critical care medicine.

[26]  I. Suramo,et al.  High-resolution computed tomography for the diagnosis of community-acquired pneumonia. , 1998, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[27]  Cynthia A. Britton,et al.  Clinical Investigations: InfectionInterobserver Reliability of the Chest Radiograph in Community-Acquired Pneumonia , 1996 .

[28]  A. Kopf,et al.  Ultrasound imaging of pneumonia. , 1995, Ultrasound in medicine & biology.

[29]  R. Rothman,et al.  Emergency management of community-acquired bacterial pneumonia: what is new since the 2007 Infectious Diseases Society of America/American Thoracic Society guidelines. , 2013, The American journal of emergency medicine.

[30]  M. Matthay,et al.  The acute respiratory distress syndrome. , 1996, The New England journal of medicine.

[31]  Sheldon P Stone,et al.  Community-acquired pneumonia , 1998, The Lancet.

[32]  V. Brusasco,et al.  Assessment of extravascular lung water by quantitative ultrasound and CT in isolated bovine lung , 2013, Respiratory Physiology & Neurobiology.

[33]  Michael J Fine,et al.  Testing Strategies in the Initial Management of Patients with Community-Acquired Pneumonia , 2002, Annals of Internal Medicine.

[34]  M. Fine,et al.  Quality of care, process, and outcomes in elderly patients with pneumonia. , 1997, JAMA.

[35]  J. Mayo,et al.  Radiation exposure at chest CT: a statement of the Fleischner Society. , 2003, Radiology.

[36]  M. Balaan,et al.  Acute Respiratory Distress Syndrome , 2016, Critical care nursing quarterly.

[37]  K. Zou,et al.  Smooth non-parametric receiver operating characteristic (ROC) curves for continuous diagnostic tests. , 1997, Statistics in medicine.

[38]  S. Szpunar,et al.  Clinical value of chest computerized tomography scans in patients admitted with pneumonia. , 2014, Journal of hospital medicine.

[39]  G. Rouan,et al.  Admission Chest Radiograph Lacks Sensitivity in the Diagnosis of Community-Acquired Pneumonia , 2009, The American journal of the medical sciences.

[40]  M. Zweig,et al.  Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. , 1993, Clinical chemistry.

[41]  P. Duca,et al.  Lung ultrasound is an accurate diagnostic tool for the diagnosis of pneumonia in the emergency department , 2010, Emergency Medicine Journal.