“STUDY OF COAGULATION PROFILE IN CLINICALLY DIAGNOSED CASES OF ACUTE DISSEMINATED INTRAVASCULAR COAGULATION USING ISTH

Disseminated Intravascular Coagulation (DIC) is a pathological activation of coagulation (blood clotting) mechanisms that happens in response to a variety of diseases. It involves the generation of intravascular fibrin (small blood clots) and the consumption of pro-coagulants and platelets. It results in the disruption of normal coagulation mechanism and abnormal bleeding occurs from the skin, the gastrointestinal tract, the respiratory tract and surgical wounds. It was the prospective study of 60 patients of acute DIC, in which coagulation profile were studied from December 2010 to October 2012. 40 controls were studied. Control group include healthy voluntary blood donors. The coagulation profile was studied and DIC scoring was performed using the International Society on Thrombosis and Haemostasis [ISTH] criteria. Among the coagulation profile, the sensitivity and specificity of the parameters to diagnose and to assess the severity of DIC, in the decreasing order of frequency were of platelet count, D-dimer, PT and APTT. Fibrinogen level was not depleted below the significant level (<1 gm/l) in majority cases of DIC. According to the ISTH criteria, DIC scores among cases was ≥ 5.