Hydrogel nanocomposites as remote-controlled biomaterials.

Nanocomposite hydrogels are a new class of intelligent materials which have recently attracted interest as biomaterials. In this study, magnetic nanocomposites of temperature-sensitive hydrogels have been developed and demonstrated to be responsive to alternating magnetic fields. Nanocomposites were synthesized by incorporation of superparamagnetic Fe(3)O(4) particles in negative temperature-sensitive poly(N-isopropylacrylamide) hydrogels. The systems were characterized for temperature-responsive swelling, remote heating on application of an alternating magnetic field and remote-controlled drug delivery applications. The rise in temperature in external alternating magnetic field depends on the Fe(3)O(4) particle loading of the system. Preliminary studies on remote-controlled drug release showed reduced release in the presence of an alternating magnetic field.

[1]  W. Kaiser,et al.  Physical limits of hyperthermia using magnetite fine particles , 1998 .

[2]  J. Kost,et al.  Magnetically enhanced insulin release in diabetic rats. , 1987, Journal of biomedical materials research.

[3]  J. Z. Hilt,et al.  Synthesis and temperature response analysis of magnetic-hydrogel nanocomposites. , 2007, Journal of biomedical materials research. Part A.

[4]  N. Peppas,et al.  Hydrogels in Pharmaceutical Formulations , 1999 .

[5]  San-Yuan Chen,et al.  Preparation and characterization of smart magnetic hydrogels and its use for drug release , 2006 .

[6]  J. Kost,et al.  Magnetically controlled release systems: effect of polymer composition. , 1985, Journal of biomedical materials research.

[7]  Takashi Miyata,et al.  A reversibly antigen-responsive hydrogel , 1999, Nature.

[8]  H. Gu,et al.  The heating effect of magnetic fluids in an alternating magnetic field , 2005 .

[9]  E. Edelman,et al.  Regulation of drug release from polymer matrices by oscillating magnetic fields. , 1985, Journal of biomedical materials research.

[10]  Edith Mathiowitz,et al.  Encyclopedia of Controlled Drug Delivery , 1999 .

[11]  J. Z. Hilt,et al.  Microfabrication of Intelligent Biomimetic Networks for Recognition of d-Glucose , 2006 .

[12]  T. Okano,et al.  Pulsatile drug delivery systems using hydrogels , 1993 .

[13]  Allan S Hoffman,et al.  Hydrogels for biomedical applications. , 2002, Advanced drug delivery reviews.

[14]  Amit K. Gupta,et al.  Ultrasensitive Biomems Sensors Based on Microcantilevers Patterned with Environmentally Responsive Hydrogels , 2003 .

[15]  Robin H. Liu,et al.  Functional hydrogel structures for autonomous flow control inside microfluidic channels , 2000, Nature.

[16]  J L West,et al.  Independent Optical Control of Microfluidic Valves Formed from Optomechanically Responsive Nanocomposite Hydrogels , 2005, Advanced materials.

[17]  A. Khademhosseini,et al.  Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology , 2006 .

[18]  Buddy D. Ratner,et al.  Biomaterials Science: An Introduction to Materials in Medicine , 1996 .

[19]  M. Zrínyi,et al.  Preparation and Responsive Properties of Magnetically Soft Poly(N-isopropylacrylamide) Gels , 2000 .

[20]  Dean-Mo Liu,et al.  Magnetic-sensitive behavior of intelligent ferrogels for controlled release of drug. , 2006, Langmuir : the ACS journal of surfaces and colloids.

[21]  M. Zrínyi,et al.  Intelligent polymer gels controlled by magnetic fields , 2000 .

[22]  Miklós Zrínyi,et al.  Kinetics of the shape change of magnetic field sensitive polymer gels , 1998 .

[23]  R. Langer,et al.  Magnetic modulation of release of macromolecules from polymers. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[24]  Toyoichi Tanaka,et al.  Volume‐phase transitions of ionized N‐isopropylacrylamide gels , 1987 .

[25]  R. Ramanujan,et al.  Magnetic and hydrogel composite materials for hyperthermia applications , 2004, Journal of materials science. Materials in medicine.

[26]  Oguz H. Elibol,et al.  Micromechanical cantilever as an ultrasensitive pH microsensor , 2002 .

[27]  K. Br,et al.  Current status of DNA vaccines in veterinary medicine. , 2000 .

[28]  Peter Babinec,et al.  SUPERPARAMAGNETIC GEL AS A NOVEL MATERIAL FOR ELECTROMAGNETICALLY INDUCED HYPERTHERMIA , 2001 .

[29]  S. Sershen,et al.  Implantable, polymeric systems for modulated drug delivery. , 2002, Advanced drug delivery reviews.