Corneal sub‐basal whorl‐like nerve plexus: a landmark for early and follow‐up evaluation in transthyretin familial amyloid polyneuropathy

Small‐fiber nerves are the first to be involved in transthyretin familial amyloid polyneuropathy (TTR‐FAP) patients. In vivo corneal confocal microscopy (CCM) is a noninvasive technique to detect small‐fiber polyneuropathy (SFN) by quantifying corneal nerve morphology. The characteristic whorl‐like pattern of the corneal nerve provides a static landmark for observation. We aimed to evaluate whether CCM images of the whorl‐like plexus can sensitively evaluate and monitor disease progression in FAP patients.

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