Elimination of 125I‐Trypsin α‐Macroglobulin Complexes from Blood by Reticuloendothelial Cells in Dog

Complexes of 125I-labelled bovine trypsin and the α1- and α2-macroglobulins of the dog were prepared and injected into 3 dogs. The rate of elimination of the radioactivity with a half time of only 8 min fitted a single exponential curve. About 80 % of the radioactivity in the whelps and about 85 % in the adult dog was recovered in the reticuloendothelial cells of the liver, spleen and bone marrow.