Extracellular material in adenoid cystic carcinoma of the salivary glands: A comparative cytological study with other salivary myoepithelial tumors

The objective of this study was to clarify extracellular materials (ECMs) in adenoid cystic carcinoma (AdCC) and compare these to those found in other salivary gland tumors with myoepithelial differentiation. The ECM was examined with Papanicolaou, May‐Grünwald‐Giemsa (MGG), and alcian blue stain at pH 2.5. The ECM in AdCC was classified into three types according to their staining patterns: clear, hyalinized, and membrane type. The incidence of clear‐type globule material with magenta on MGG was low in other salivary gland tumors with myoepithelial differentiation. The ECM was identified in other salivary gland tumors with myoepithelial differentiation. However, AdCC has the greatest variety of ECM. These findings are useful to understand the character of AdCC and differential diagnosis of the other salivary gland tumors with myoepithelial differentiation. Diagn. Cytopathol. 2004;31:14–18. © 2004 Wiley‐Liss, Inc.

[1]  M. Kage,et al.  Cytomorphologic Features of a Polymorphous Low Grade Adenocarcinoma of the Palate , 2003, Acta Cytologica.

[2]  R. Raitz,et al.  Polymorphous low‐grade adenocarcinoma and adenoid cystic carcinoma: distinct architectural composition revealed by collagen IV, laminin and their integrin ligands (α2β1 and α3β1) , 2000 .

[3]  P. Ip,et al.  Fine Needle Aspiration Cytology of Epithelial-Myoepithelial Carcinoma of Salivary Glands , 1999, Acta Cytologica.

[4]  R. Laskawi,et al.  Cytologic diagnosis of adenoid cystic carcinoma of salivary glands , 1999, Diagnostic cytopathology.

[5]  R. Ashfaq,et al.  Fine‐needle aspiration findings in patients with polymorphous low grade adenocarcinoma of the salivary glands , 1999, Cancer.

[6]  J. Klijanienko,et al.  Fine‐needle sampling of salivary gland lesions III. cytologic and histologic correlation of 75 cases of adenoid cystic carcinoma: Review and experience at the Institut Curie with emphasis on cytologic pitfalls , 1997, Diagnostic cytopathology.

[7]  J. Jang,et al.  Differential diagnosis of adenoid cystic carcinoma from pleomorphic adenoma of the salivary gland on fine needle aspiration cytology. , 1996, Acta cytologica.

[8]  L. Layfield,et al.  Epithelial‐myoepithelial cell carcinoma of the parotid gland: A case report and comparison of cytologic features with other stromal, epithelial, and myoepithelial cell containing lesions of the salivary glands , 1996, Diagnostic cytopathology.

[9]  J. Klijanienko,et al.  Fine‐needle sampling of salivary gland lesions I. Cytology and histology correlation of 412 cases of pleomorphic adenoma , 1996, Diagnostic cytopathology.

[10]  C. Ballestín,et al.  Fine‐needle aspiration cytology of a membranous basal cell adenoma arising in an intraparotid lymph node , 1993, Diagnostic cytopathology.

[11]  T. Saku,et al.  Basement membranes in adenoid cystic carcinoma an immunohistochemical study , 1992, Cancer.

[12]  M. Stanley,et al.  Basal‐cell adenoma of the salivary gland: A benign adenoma that cytologically mimics adenoid cystic carcinoma , 1988, Diagnostic cytopathology.

[13]  J. Orenstein,et al.  Ultrastructural similarities of adenoid cystic carcinoma and pleomorphic adenoma , 1985, Histopathology.

[14]  B. Tandler.  Ultrastructure of adenoid cystic carcinoma of salivary gland origin. , 1971, Laboratory investigation; a journal of technical methods and pathology.