Neuroendocrinology of the hair follicle: principles and clinical perspectives.

[1]  Y. Ramot,et al.  Harnessing neuroendocrine controls of keratin expression: A new therapeutic strategy for skin diseases? , 2014, BioEssays : news and reviews in molecular, cellular and developmental biology.

[2]  R. Paus,et al.  α‐Melanocyte‐stimulating hormone: a protective peptide against chemotherapy‐induced hair follicle damage? , 2014, The British journal of dermatology.

[3]  R. Paus,et al.  A meeting of two chronobiological systems: circadian proteins Period1 and BMAL1 modulate the human hair cycle clock. , 2014, The Journal of investigative dermatology.

[4]  N. Binart,et al.  Prolactin and adipose tissue. , 2014, Biochimie.

[5]  R. Latif,et al.  Targeting thyroid diseases with TSH receptor analogs. , 2013, Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion.

[6]  R. Paus,et al.  Lichen planopilaris is characterized by immune privilege collapse of the hair follicle's epithelial stem cell niche , 2013, The Journal of pathology.

[7]  D. Tobin,et al.  Key role of CRF in the skin stress response system. , 2013, Endocrine reviews.

[8]  R. Paus.  Migrating melanocyte stem cells: masters of disaster? , 2013, Nature Network Boston.

[9]  J. Shapiro,et al.  Somatostatin expression in human hair follicles and its potential role in immune privilege. , 2013, The Journal of investigative dermatology.

[10]  R. Paus,et al.  Cannabinoid receptor 1 controls human mucosal-type mast cell degranulation and maturation in situ. , 2013, The Journal of allergy and clinical immunology.

[11]  T. Bíró,et al.  Is thyrotropin‐releasing hormone a novel neuroendocrine modulator of keratin expression in human skin? , 2013, The British journal of dermatology.

[12]  Piul S. Rabbani,et al.  Direct migration of follicular melanocyte stem cells to the epidermis after wounding or UVB irradiation is dependent on Mc1r signaling , 2013, Nature Medicine.

[13]  C. Chuong,et al.  Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling , 2013, Proceedings of the National Academy of Sciences.

[14]  K. Murao,et al.  Chronic Restraint Stress Inhibits Hair Growth via Substance P Mediated by Reactive Oxygen Species in Mice , 2013, PloS one.

[15]  R. Paus,et al.  Tumour Necrosis Factor Alpha, Interferon Gamma and Substance P Are Novel Modulators of Extrapituitary Prolactin Expression in Human Skin , 2013, PloS one.

[16]  S. Inui,et al.  Androgen actions on the human hair follicle: perspectives , 2013, Experimental dermatology.

[17]  J. Kloepper,et al.  Dopamine is a novel, direct inducer of catagen in human scalp hair follicles in vitro , 2013, British Journal of Dermatology.

[18]  Y. Ramot,et al.  A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ , 2013, PeerJ.

[19]  P. Coulombe,et al.  The expanding significance of keratin intermediate filaments in normal and diseased epithelia. , 2013, Current opinion in cell biology.

[20]  Ralf Paus,et al.  Pathobiology of chemotherapy-induced hair loss. , 2013, The Lancet. Oncology.

[21]  M. Mildner,et al.  Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model , 2012, Allergy.

[22]  B. McEwen,et al.  Brain on stress: How the social environment gets under the skin , 2012, Proceedings of the National Academy of Sciences.

[23]  M. Goodfellow,et al.  A prototypic mathematical model of the human hair cycle. , 2012, Journal of Theoretical Biology.

[24]  R. Paus,et al.  Neural controls of human hair growth: calcitonin gene-related peptide (CGRP) induces catagen. , 2012, Journal of dermatological science.

[25]  R. H. Costa-e-Sousa,et al.  Minireview: The neural regulation of the hypothalamic-pituitary-thyroid axis. , 2012, Endocrinology.

[26]  R. Paus,et al.  The neuropeptide galanin is a novel inhibitor of human hair growth , 2012, The British journal of dermatology.

[27]  Ralf Paus,et al.  Utilizing the hair follicle to dissect the regulation and autocrine/paracrine activities of prolactin in humans. , 2012, American Journal of Physiology. Endocrinology and Metabolism.

[28]  G. Gutiérrez-Ospina,et al.  Modulatory Role of Sensory Innervation on Hair Follicle Stem Cell Progeny during Wound Healing of the Rat Skin , 2012, PloS one.

[29]  C. Clapp,et al.  Prolactin and blood vessels: a comparative endocrinology perspective. , 2012, General and comparative endocrinology.

[30]  Annik Prat,et al.  The biology and therapeutic targeting of the proprotein convertases , 2012, Nature Reviews Drug Discovery.

[31]  R. Paus,et al.  Endocannabinoids limit excessive mast cell maturation and activation in human skin. , 2012, The Journal of allergy and clinical immunology.

[32]  R. Paus,et al.  Calcitonin gene‐related peptide (CGRP) may award relative protection from interferon‐γ‐induced collapse of human hair follicle immune privilege , 2012, Experimental dermatology.

[33]  M. Bernadet,et al.  Prolactin receptor antagonism in mouse anterior pituitary: effects on cell turnover and prolactin receptor expression. , 2012, American journal of physiology. Endocrinology and metabolism.

[34]  R. Paus,et al.  Thyrotropin-releasing hormone controls mitochondrial biology in human epidermis. , 2012, The Journal of clinical endocrinology and metabolism.

[35]  G. Lutz.  Hair loss and hyperprolactinemia in women , 2012, Dermato-endocrinology.

[36]  R. Paus,et al.  Thyrotropin-releasing hormone selectively stimulates human hair follicle pigmentation. , 2011, The Journal of investigative dermatology.

[37]  I. Jonsdottir,et al.  Prolactin in response to acute psychosocial stress in healthy men and women , 2011, Psychoneuroendocrinology.

[38]  B. Andersen,et al.  Identification of novel telogen markers underscores that telogen is far from a quiescent hair cycle phase , 2011, The Journal of investigative dermatology.

[39]  Kailas S. Khomane,et al.  Novel thyrotropin-releasing hormone analogs: a patent review , 2011, Expert opinion on therapeutic patents.

[40]  Y. Ramot,et al.  TSH is a novel neuroendocrine regulator of selected keratins in the human hair follicle. , 2011, Journal of dermatological science.

[41]  Timothy B. Rowe,et al.  Fossil Evidence on Origin of the Mammalian Brain , 2011, Science.

[42]  A. Joyner,et al.  Nerve-derived sonic hedgehog defines a niche for hair follicle stem cells capable of becoming epidermal stem cells. , 2011, Cell stem cell.

[43]  H. Urbanski.  Role of Circadian Neuroendocrine Rhythms in the Control of Behavior and Physiology , 2011, Neuroendocrinology.

[44]  R. Dores,et al.  Evolution of POMC: origin, phylogeny, posttranslational processing, and the melanocortins , 2011, Annals of the New York Academy of Sciences.

[45]  D. Tobin,et al.  Regulated proenkephalin expression in human skin and cultured skin cells. , 2011, The Journal of investigative dermatology.

[46]  R. Guillemin.  Neuroendocrinology: a short historical review , 2011, Annals of the New York Academy of Sciences.

[47]  Y. Taché,et al.  CRF Receptor Antagonist Astressin-B Reverses and Prevents Alopecia in CRF Over-Expressing Mice , 2011, PloS one.

[48]  R. Paus.  A neuroendocrinological perspective on human hair follicle pigmentation , 2011, Pigment cell & melanoma research.

[49]  R. Paus,et al.  Exploring the "hair growth-wound healing connection": anagen phase promotes wound re-epithelialization. , 2011, The Journal of investigative dermatology.

[50]  T. Kruger,et al.  Prolactin secretion patterns: basic mechanisms and clinical implications for reproduction. , 2010, Reproduction.

[51]  Ralf Paus,et al.  Female pattern hair loss: beyond an androgenic aetiology? , 2010, The British journal of dermatology.

[52]  R. Paus,et al.  Endocrine controls of primary adult human stem cell biology: thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro. , 2010, European journal of cell biology.

[53]  Y. Ramot,et al.  Prolactin: an emerging force along the cutaneous–endocrine axis , 2010, Trends in Endocrinology & Metabolism.

[54]  Y. Ramot,et al.  Prolactin—a novel neuroendocrine regulator of human keratin expression in situ , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[55]  Y. Ramot,et al.  Thyrotropin‐releasing hormone and oestrogen differentially regulate prolactin and prolactin receptor expression in female human skin and hair follicles in vitro , 2010, The British journal of dermatology.

[56]  R. Paus,et al.  Thyrotropin powers human mitochondria , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[57]  Y. Ramot,et al.  Thyroid-stimulating hormone, a novel, locally produced modulator of human epidermal functions, is regulated by thyrotropin-releasing hormone and thyroid hormones. , 2010, Endocrinology.

[58]  R. Paus,et al.  Corticotropin-releasing hormone stimulates the in situ generation of mast cells from precursors in the human hair follicle mesenchyme. , 2010, The Journal of investigative dermatology.

[59]  Y. Ramot,et al.  Mind the (gender) gap: does prolactin exert gender and/or site-specific effects on the human hair follicle? , 2010, The Journal of investigative dermatology.

[60]  R. Paus,et al.  Methods in hair research: how to objectively distinguish between anagen and catagen in human hair follicle organ culture , 2010, Experimental dermatology.

[61]  Y. Ramot,et al.  Thyrotropin releasing hormone (TRH): a new player in human hair‐growth control , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[62]  R. Paus,et al.  The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities. , 2009, Trends in pharmacological sciences.

[63]  R. Paus,et al.  Profiling the response of human hair follicles to ultraviolet radiation. , 2009, The Journal of investigative dermatology.

[64]  Padhraic Smyth,et al.  Circadian Clock Genes Contribute to the Regulation of Hair Follicle Cycling , 2009, PLoS genetics.

[65]  P. Arck,et al.  Neuroendocrine perspectives in alopecia areata: does stress play a role? , 2009, The Journal of investigative dermatology.

[66]  R. Paus,et al.  Human female hair follicles are a direct, nonclassical target for thyroid-stimulating hormone. , 2009, The Journal of investigative dermatology.

[67]  S. Güler,et al.  Skin findings in thyroid diseases. , 2009, European journal of internal medicine.

[68]  Ralf Paus,et al.  The Hair Follicle as a Dynamic Miniorgan , 2009, Current Biology.

[69]  R. Paus,et al.  Thyroid hormones directly alter human hair follicle functions: anagen prolongation and stimulation of both hair matrix keratinocyte proliferation and hair pigmentation. , 2008, The Journal of clinical endocrinology and metabolism.

[70]  R. Paus,et al.  Evidence that the bulge region is a site of relative immune privilege in human hair follicles , 2008, The British journal of dermatology.

[71]  T. Luger,et al.  Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases. , 2008, Endocrine reviews.

[72]  P. Arck,et al.  Probing the effects of stress mediators on the human hair follicle: substance P holds central position. , 2007, The American journal of pathology.

[73]  D. Tobin,et al.  Melatonin and the hair follicle , 2007, Journal of pineal research.

[74]  C. Kruse,et al.  Hair follicle stem cells: walking the maze. , 2007, European journal of cell biology.

[75]  D. Tobin,et al.  Proopiomelanocortin (POMC), the ACTH/ melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[76]  R. Paus,et al.  The M4 muscarinic acetylcholine receptor plays a key role in the control of murine hair follicle cycling and pigmentation. , 2007, Life sciences.

[77]  G. Robinson,et al.  BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction , 2007, Development.

[78]  P. Arck,et al.  Neuroimmunology of stress: skin takes center stage. , 2006, The Journal of investigative dermatology.

[79]  J. Gustafsson,et al.  The hair follicle as an estrogen target and source. , 2006, Endocrine reviews.

[80]  D. Tobin,et al.  Modulation of the human hair follicle pigmentary unit by corticotropin‐releasing hormone and urocortin peptides , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[81]  R. Paus,et al.  Human scalp hair follicles are both a target and a source of prolactin, which serves as an autocrine and/or paracrine promoter of apoptosis-driven hair follicle regression. , 2006, The American journal of pathology.

[82]  D. Tobin,et al.  Hair melanocytes as neuro-endocrine sensors—Pigments for our imagination , 2005, Molecular and Cellular Endocrinology.

[83]  R. Paus,et al.  Human hair follicles display a functional equivalent of the hypothalamic‐pituitary‐adrenal (HPA) axis and synthesize cortisol , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[84]  S. Hunt,et al.  Mast cell deficient and neurokinin-1 receptor knockout mice are protected from stress-induced hair growth inhibition , 2005, Journal of Molecular Medicine.

[85]  D. Tobin,et al.  A fully functional proopiomelanocortin/melanocortin-1 receptor system regulates the differentiation of human scalp hair follicle melanocytes. , 2005, Endocrinology.

[86]  D. Tobin,et al.  The cutaneous serotoninergic/melatoninergic system: securing a place under the sun , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[87]  Achim Peters.  The self-similarity of the melanocortin system. , 2005, Endocrinology.

[88]  R. Paus,et al.  In search of the "hair cycle clock": a guided tour. , 2004, Differentiation; research in biological diversity.

[89]  P. Arck,et al.  Burden of hair loss: stress and the underestimated psychosocial impact of telogen effluvium and androgenetic alopecia. , 2004, The Journal of investigative dermatology.

[90]  D. Tobin,et al.  beta-Endorphin as a regulator of human hair follicle melanocyte biology. , 2004, The Journal of investigative dermatology.

[91]  A. Klausegger,et al.  Expression of neuropeptide galanin and galanin receptors in human skin. , 2004, The Journal of investigative dermatology.

[92]  R. Paus,et al.  Collapse and restoration of MHC class-I-dependent immune privilege: exploiting the human hair follicle as a model. , 2004, The American journal of pathology.

[93]  J. Mazurkiewicz,et al.  Differential expression of a cutaneous corticotropin-releasing hormone system. , 2004, Endocrinology.

[94]  R. Paus,et al.  Prolactin and its receptor are expressed in murine hair follicle epithelium, show hair cycle-dependent expression, and induce catagen. , 2003, The American journal of pathology.

[95]  J. Foley,et al.  Hair-cycle-dependent expression of parathyroid hormone-related protein and its type I receptor: evidence for regulation at the anagen to catagen transition. , 2003, The Journal of investigative dermatology.

[96]  D. Tobin,et al.  Expression of hypothalamic-pituitary-thyroid axis related genes in the human skin. , 2002, The Journal of investigative dermatology.

[97]  X. Tong,et al.  Keratin 17 null mice exhibit age- and strain-dependent alopecia. , 2002, Genes & development.

[98]  R. Paus,et al.  Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. , 2000, Physiological reviews.

[99]  A. Messenger.  Thyroid hormone and hair growth , 2000, The British journal of dermatology.

[100]  G. Nagy,et al.  Prolactin: structure, function, and regulation of secretion. , 2000, Physiological reviews.

[101]  R. Paus,et al.  Hair cycle-dependent changes in adrenergic skin innervation, and hair growth modulation by adrenergic drugs. , 1999, The Journal of investigative dermatology.

[102]  R. Boissy,et al.  What's the use of generating melanin? , 1999, Experimental dermatology.

[103]  A. Chakraborty,et al.  Hair cycle-dependent production of ACTH in mouse skin. , 1998, Biochimica et biophysica acta.

[104]  R. Paus,et al.  Hair cycle-dependent expression of corticotropin-releasing factor (CRF) and CRF receptors in murine skin. , 1998, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[105]  R. Paus,et al.  Activated skin mast cells are involved in murine hair follicle regression (catagen). , 1997, Laboratory investigation; a journal of technical methods and pathology.

[106]  S. Eichmüller,et al.  A murine model for inducing and manipulating hair follicle regression (catagen): effects of dexamethasone and cyclosporin A. , 1994, The Journal of investigative dermatology.

[107]  R. Paus,et al.  Hair growth induction by substance P. , 1994, Laboratory investigation; a journal of technical methods and pathology.

[108]  R. Paus,et al.  Mast cell involvement in murine hair growth. , 1994, Developmental biology.

[109]  R. Paus,et al.  Nerve growth factor modulates keratinocyte proliferation in murine skin organ culture , 1994, The British journal of dermatology.

[110]  D. Schadendorf,et al.  Melanocytes as "sensory" and regulatory cells in the epidermis. , 1993, Journal of theoretical biology.

[111]  J. Mazurkiewicz,et al.  Proopiomelanocortin expression in the skin during induced hair growth in mice , 1992, Experientia.

[112]  R. Paus,et al.  Hypothalamic-pituitary-thyroid axis hormones stimulate mitochondrial function and biogenesis in human hair follicles. , 2014, The Journal of investigative dermatology.

[113]  V. L. Goryachkina,et al.  [Regulation of hair follicle cycle]. , 2014, Morfologiia.

[114]  J. Levine.  An Introduction to Neuroendocrine Systems , 2012 .

[115]  N. Sharma,et al.  Biochemical association of hyperprolactinemia with hypothyroidism in infertile women. , 2012, Clinical laboratory.

[116]  M. Novotny,et al.  Identification of markers for nipple epidermis: changes in expression during pregnancy and lactation. , 2007, Differentiation; research in biological diversity.

[117]  J. Schweizer,et al.  Keratins of the human hair follicle. , 2005, International review of cytology.

[118]  R. Paus,et al.  A 'hairy' privilege. , 2005, Trends in immunology.

[119]  R. Paus,et al.  The human hair bulb is a source and target of CRH. , 2004, The Journal of investigative dermatology.

[120]  L. Sumanovski,et al.  Different Expression of μ-Opiate Receptor in Chronic and Acute Wounds and the Effect of β-Endorphin on Transforming Growth Factor β Type II Receptor and Cytokeratin 16 Expression , 2003 .

[121]  R Paus,et al.  Controls of hair follicle cycling. , 2001, Physiological reviews.

[122]  G. Chrousos,et al.  Corticotropin-Releasing Hormone Induces Skin Mast Cell Degranulation and Increased Vascular Permeability, A Possible Explanation for Its Proinflammatory Effects. , 1998, Endocrinology.

[123]  S. Eichmüller,et al.  Neural mechanisms of hair growth control. , 1997, The journal of investigative dermatology. Symposium proceedings.

[124]  R. Paus,et al.  Sequential expression of glutathione-S-transferase isoenzymes during hair growth phases in mice and their relationship to caldesmon, phosphotyrosinase and VIP receptor protein. , 1995, Histology and histopathology.

[125]  R. Lobo,et al.  Prolactin modulates peripheral androgen metabolism. , 1986, Fertility and sterility.