Adenoid Cystic Carcinoma: Report of Two Cases with Review of the Literature

Adenoid Cystic Carcinoma (ACC) is an indolent, slow-growing malignant tumor which occurs frequently in hard palate associated with minor salivary glands. It is an aggressive neoplasm characterized by early neural invasion and a high incidence of multiple recurrence and distant metastases, which may develop years after the initial resection. Surgery followed by radiotherapy seems to be the best treatment. ACC patients have a limited prognosis, even after radical surgery and radiotherapy. Present article describes two cases involving adenoid cystic carcinoma of the maxilla with different treatment modalities.

[1]  B. Adeyemi,et al.  A review of 413 salivary gland tumours in the head and neck region , 2013, Journal of clinical and experimental dentistry.

[2]  N. Kakimoto,et al.  Perineural spread of adenoid cystic carcinoma in the oral and maxillofacial regions: evaluation with contrast-enhanced CT and MRI. , 2012, Dento maxillo facial radiology.

[3]  J. Buatti,et al.  Role of radiotherapy in adenoid cystic carcinoma of the head and neck , 2009, The Journal of Laryngology & Otology.

[4]  Dong Jin Lee,et al.  Necrotizing Sialometaplasia Accompanied by Adenoid Cystic Carcinoma on the Soft Palate , 2009, Clinical and experimental otorhinolaryngology.

[5]  R. Mesquita,et al.  Adenoid cystic carcinoma in palate and maxillary sinus , 2006, Brazilian journal of otorhinolaryngology.

[6]  L. Thompson,et al.  World Health Organization Classification of Tumours: Pathology and Genetics of Head and Neck Tumours , 2006, Ear, nose, & throat journal.

[7]  P. Bradley.  Adenoid cystic carcinoma of the head and neck: a review , 2004, Current opinion in otolaryngology & head and neck surgery.

[8]  D. Ross,et al.  Adenoid cystic carcinoma: A retrospective clinical review , 2001, International journal of cancer.

[9]  D. Migliari,et al.  Hard palate perforation: an unusual finding in paracoccidioidomycosis , 2001, International journal of dermatology.

[10]  H. Goepfert,et al.  Adenoid cystic carcinoma of the head and neck: Predictors of morbidity and mortality , 1999 .

[11]  Horton,et al.  Metastatic Adenoid Cystic Carcinoma of Salivary Glands: Case Reports and Review of the Literature. , 1996, Cancer control : journal of the Moffitt Cancer Center.

[12]  R. Spiro,et al.  Adenoid cystic carcinoma of salivary origin. A clinicopathologic study of 242 cases. , 1974, American journal of surgery.

[13]  H. W. Baker,et al.  Adenoid cystic carcinoma of the head and neck. , 1972, Cancer.

[14]  E. Shinohara,et al.  An unusual case of adenoid cystic carcinoma with hard palate perforation. , 2011, Minerva stomatologica.

[15]  A. Eckardt,et al.  Adenoid cystic carcinoma of the head and neck--a 20 years experience. , 2004, International journal of oral and maxillofacial surgery.