The stress/strain and fatigue behaviour of glutaraldehyde preserved heart-valve tissue.

Abstract Static tensile tests and accelerated fatigue tests were used to investigate the mechanical durability of glutaraldehyde preserved bovine and porcine mitral tissue with a view to gaining some understanding of the long-term functional behaviour of preserved heterografts. As well as there being a reduction in the tissue compliance following fixation, the effects of cyclic loading over a wide range of peak stresses were to reduce further the tissue compliance. Fatigue induced structural changes leading finally to gross disruption of the collagen fibre array were observed using optical and electron microscopy.

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