In line with the space strategy of the German Government, ISS follow-on activities should comprise clear scientific objectives and key technological competences (e.g. robotic, internal and external structures, module/facility and experiment operations, interface systems (ATV)). In this way, DLR started to investigate future options by evaluating various LEO infrastructure concepts including opportunities for national realisation or international cooperation. A corresponding list of options can be found below. DLR scientists from various disciplines were asked to assess the usability of these options and design payloads based on their Mir and ISS experience and with respect to future scientific fundamental and technological research questions.