Evaluation of breast tumor margins in vivo with intraoperative photoacoustic imaging.

The use of photoacoustic effect is a promising approach for biomedical imaging in living tissues. Photoacoustic tomography (PAT) has been demonstrated to image breast cancer, brain vasculature, arthritis and seizure focus owing to its rich optical contrast and high resolution in a single imaging modality. Here we report a microelectromechanical systems (MEMS)-based intraoperative PAT (iPAT) technique, and demonstrate its ability to accurately map tumors in three-dimension and to inspect the completeness of tumor resection during surgery in a tumor-bearing mouse model. The MEMS imaging probe is small and has the potential to be conveniently used to guide surgical resection of tumors in the breast.

[1]  Huikai Xie,et al.  A large vertical displacement electrothermal bimorph microactuator with very small lateral shift , 2008 .

[2]  Mark C Kelley,et al.  Accuracy of Intraoperative Gross Examination of Surgical Margin Status in Women Undergoing Partial Mastectomy for Breast Malignancy , 2005, The American surgeon.

[3]  R. Kruger,et al.  Breast cancer in vivo: contrast enhancement with thermoacoustic CT at 434 MHz-feasibility study. , 2000, Radiology.

[4]  Ryan L. Shelton,et al.  Off-Axis Photoacoustic Microscopy , 2010, IEEE Transactions on Biomedical Engineering.

[5]  Merrick I Ross,et al.  Positive surgical margins and ipsilateral breast tumor recurrence predict disease‐specific survival after breast‐conserving therapy , 2003, Cancer.

[6]  Chulhong Kim,et al.  Sentinel lymph nodes and lymphatic vessels: noninvasive dual-modality in vivo mapping by using indocyanine green in rats--volumetric spectroscopic photoacoustic imaging and planar fluorescence imaging. , 2010, Radiology.

[7]  Wiendelt Steenbergen,et al.  Photoacoustic mammography laboratory prototype: imaging of breast tissue phantoms. , 2004, Journal of biomedical optics.

[8]  T. Powles,et al.  Local relapse in primary breast cancer patients with unexcised positive surgical margins after lumpectomy, radiotherapy and chemoendocrine therapy. , 1999, Annals of oncology : official journal of the European Society for Medical Oncology.

[9]  Manojit Pramanik,et al.  Sentinel lymph nodes in the rat: noninvasive photoacoustic and US imaging with a clinical US system. , 2010, Radiology.

[10]  Lihong V. Wang.  Multiscale photoacoustic microscopy and computed tomography. , 2009, Nature photonics.

[11]  Saveli Goldberg,et al.  Current Perceptions Regarding Surgical Margin Status After Breast-Conserving Therapy: Results of a Survey , 2005, Annals of surgery.

[12]  Qifa Zhou,et al.  PMN-PT single crystal, high-frequency ultrasonic needle transducers for pulsed-wave Doppler application , 2007, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[13]  A. Jemal,et al.  Cancer Statistics, 2008 , 2008, CA: a cancer journal for clinicians.

[14]  A. Vincent-Salomon,et al.  Histological margin assessment for breast ductal carcinoma in situ: precision and implications , 2004, Modern Pathology.