TIME‐TEMPERATURE RELATIONSHIPS FOR HEAT‐INDUCED KILLING OF MAMMALIAN CELLS *

Kinetic analyses of heat-induced cell killing in vitro have been used by numerous investigators in the hope of associating cell death a t elevated temperatures with either general of specific molecular events.l4 Similarly, hyperthermic damage to tissues in vivo has been studied as a function of temperature with the aims of (1) demonstrating a differential response in tumor versus normal tissue, and (2) understanding these effects either in terms of cell killing and/or the perturbed physiological response to heat.7-’’ The motive for most of these studies has been the desire either to take advantage of some inherent greater heat sensitivity of tumor cells compared to the surrounding normal cells and, thus, achieve a therapeutic advantage, or to manipulate the biology of heat death so as to produce a differential effect. This paper will review the data, compare the kinetics of cellular and tissue damage, and examine the conclusions that can be drawn from these various sets of data.

[1]  J. Overgaard,et al.  Investigations on the possibility of a thermic tumour therapy. I. Short-wave treatment of a transplanted isologous mouse mammary carcinoma. , 1972, European journal of cancer.

[2]  R. Winward,et al.  The kinetics of increase in chromatin protein content in heated cells: a possible role in cell killing. , 1979, Radiation research.

[3]  C. Heidelberger,et al.  Studies on the quantitative biology of hyperthermic killing of HeLa cells. , 1973, Cancer research.

[4]  E. Gerner,et al.  A transient thermotolerant survival response produced by single thermal doses in HeLa cells. , 1976, Cancer research.

[5]  N. Marceau,et al.  Rate-limiting events in hyperthermic cell killing. , 1978, Radiation research.

[6]  Henry Eyring,et al.  The theory of rate processes in biology and medicine , 1974 .

[7]  K. Henle,et al.  Arrhenius analysis of heat survival curves from normal and thermotolerant CHO cells. , 1979, Radiation research.

[8]  A M Kellerer,et al.  RBE and the primary mechanism of radiation action. , 1971, Radiation research.

[9]  H. Hewitt.  The choice of animal tumors for experimental studies of cancer therapy. , 1978, Advances in cancer research.

[10]  A. Moritz,et al.  Studies of Thermal Injury: II. The Relative Importance of Time and Surface Temperature in the Causation of Cutaneous Burns. , 1947, The American journal of pathology.

[11]  O. S. Nielsen,et al.  Effect of extracellular pH on thermotolerance and recovery of hyperthermic damage in vitro. , 1979, Cancer research.

[12]  L. Gerweck.  Modification of Cell Lethality at Elevated TemperaturesThe pH Effect1 , 1977 .

[13]  H. A. Johnson.  On the thermodynamics of cell injury. Some insights into the molecular mechanisms. , 1974, The American journal of pathology.

[14]  J. Leith,et al.  Response of 9L tumor cells to hyperthermia and X irradiation. , 1979, Radiation research.

[15]  J. Dickson.  The effects of hyperthermia in animal tumour systems. , 1977, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

[16]  K. Henle,et al.  Induction of Thermotolerance in Chinese Hamster Ovary Cells by High (45°) or Low (40°) Hyperthermia , 1978 .

[17]  E. Atkinson.  Microwave-Induced Hyperthermia Dose Definition , 1978 .

[18]  M. Harris.  Growth and survival of mammalian cells under continuous thermal stress. , 1969, Experimental cell research.

[19]  H. A. Johnson,et al.  Thermal injury due to normal body temperature. , 1972, The American journal of pathology.

[20]  W. Dewey,et al.  Cellular responses to combinations of hyperthermia and radiation. , 1977, Radiology.

[21]  J. Overgaard,et al.  Effect of hyperthermia on malignant cells in vivo: A review and a hypothesis , 1977, Cancer.

[22]  K H Chadwick,et al.  A molecular theory of cell survival. , 1973, Physics in medicine and biology.

[23]  S. B. Field,et al.  The response of the mouse ear to heat applied alone or combined with X rays. , 1978, The British journal of radiology.

[24]  G. Crile.  The effects of heat and radiation on cancers implanted on the feet of mice. , 1963, Cancer research.

[25]  K. Henle,et al.  Interaction of hyperthermia and radiation in CHO cells: recovery kinetics. , 1976, Radiation research.

[26]  H. Suit.  Hyperthermic effects on animal tissues. , 1977, Radiology.

[27]  S. B. Field,et al.  The response of the rat tail to hyperthermia. , 1977, The British journal of radiology.

[28]  E. Gerner,et al.  Prospects for hyperthermia in human cancer therapy. Part II: implications of biological and physical data for applications of hyperthermia to man. , 1977, Radiology.

[29]  J. E. Robinson,et al.  Thermal sensitivity and the effect of elevated temperatures on the radiation sensitivity of Chinese hamster cells. , 1974, Acta radiologica: therapy, physics, biology.

[30]  K. Henle,et al.  Combinations of hyperthermia (40 degrees, 45 degrees C) with radiation. , 1976, Radiology.

[31]  B. Mondovì,et al.  Selective Heat Sensitivity of Cancer Cells , 1977, Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer.

[32]  J. Dickson,et al.  Stimulation of tumour cell dissemination by raised temperature (42°C) in rats with transplanted Yoshida tumours , 1974, Nature.

[33]  G. Hahn,et al.  Tumor cure and cell survival after localized radiofrequency heating. , 1977, Cancer research.

[34]  W. Dewey,et al.  Variation in sensitivity to heat shock during the cell-cycle of Chinese hamster cells in vitro. , 1971, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[35]  J W Gray,et al.  Effects of hyperthermia on survival and progression of Chinese hamster ovary cells. , 1978, Cancer research.