Why lipids are important for Alzheimer disease?
暂无分享,去创建一个
[1] A. Tall,et al. ATP‐binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[2] D. Holtzman,et al. Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. , 2008, The Journal of clinical investigation.
[3] Paul T. Tarr,et al. ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2 Published, JLR Papers in Press, October 4, 2007. , 2008, Journal of Lipid Research.
[4] L. Muglia,et al. Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1 , 2007, Neuron.
[5] A. Tall,et al. High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1 , 2007, Proceedings of the National Academy of Sciences.
[6] Peter Tontonoz,et al. Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors , 2007, Proceedings of the National Academy of Sciences.
[7] D. Holtzman,et al. Transport Pathways for Clearance of Human Alzheimer's Amyloid β-Peptide and Apolipoproteins E and J in the Mouse Central Nervous System , 2007, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[8] C. Wellington,et al. The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of β-amyloid precursor protein Published, JLR Papers in Press, February 10, 2007. , 2007, Journal of Lipid Research.
[9] M. Hayden,et al. Physiologically regulated transgenic ABCA1 does not reduce amyloid burden or amyloid-beta peptide levels in vivo. , 2007, Journal of lipid research.
[10] T. Comery,et al. The LXR agonist TO901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer's disease , 2007, Molecular and Cellular Neuroscience.
[11] T. V. van Berkel,et al. Total Body ABCG1 Expression Protects Against Early Atherosclerotic Lesion Development in Mice , 2007, Arteriosclerosis, thrombosis, and vascular biology.
[12] A. Hill,et al. Role of ABCG1 and ABCA1 in Regulation of Neuronal Cholesterol Efflux to Apolipoprotein E Discs and Suppression of Amyloid-β Peptide Generation* , 2007, Journal of Biological Chemistry.
[13] A. Vaughan,et al. ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL Published, JLR Papers in Press, August 10, 2006. , 2006, Journal of Lipid Research.
[14] Paul T. Tarr,et al. Deletion of the Transmembrane Transporter ABCG1 Results in Progressive Pulmonary Lipidosis* , 2006, Journal of Biological Chemistry.
[15] K. Ueda,et al. Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1s⃞ Published, JLR Papers in Press, May 15, 2006. , 2006, Journal of Lipid Research.
[16] Lilit Vardanian,et al. The effects of ABCA1 on cholesterol efflux and Aβ levels in vitro and in vivo , 2006, Journal of neurochemistry.
[17] A. von Eckardstein,et al. Lipid efflux by the ATP-binding cassette transporters ABCA1 and ABCG1. , 2006, Biochimica et biophysica acta.
[18] A. Tall,et al. LXR-Induced Redistribution of ABCG1 to Plasma Membrane in Macrophages Enhances Cholesterol Mass Efflux to HDL , 2006, Arteriosclerosis, thrombosis, and vascular biology.
[19] P. Tontonoz,et al. Liver X receptors as integrators of metabolic and inflammatory signaling. , 2006, The Journal of clinical investigation.
[20] Barbara Karten,et al. Expression of ABCG1, but Not ABCA1, Correlates with Cholesterol Release by Cerebellar Astroglia* , 2006, Journal of Biological Chemistry.
[21] D. Mangelsdorf,et al. LXRS and FXR: the yin and yang of cholesterol and fat metabolism. , 2006, Annual review of physiology.
[22] Yadong Huang. Apolipoprotein E and Alzheimer disease , 2006, Neurology.
[23] Peter Tontonoz,et al. Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia. , 2006, Annual review of medicine.
[24] M. Hayden,et al. The Absence of ABCA1 Decreases Soluble ApoE Levels but Does Not Diminish Amyloid Deposition in Two Murine Models of Alzheimer Disease* , 2005, Journal of Biological Chemistry.
[25] D. Holtzman,et al. Deletion of Abca1 Increases Aβ Deposition in the PDAPP Transgenic Mouse Model of Alzheimer Disease* , 2005, Journal of Biological Chemistry.
[26] M. Staufenbiel,et al. Lack of ABCA1 Considerably Decreases Brain ApoE Level and Increases Amyloid Deposition in APP23 Mice* , 2005, Journal of Biological Chemistry.
[27] I. Gelissen,et al. ABCA1 and ABCG1 Synergize to Mediate Cholesterol Export to ApoA-I , 2005, Arteriosclerosis, thrombosis, and vascular biology.
[28] J. Heinecke,et al. ATP-binding cassette transporter A1: a cell cholesterol exporter that protects against cardiovascular disease. , 2005, Physiological reviews.
[29] A. Vaughan,et al. ABCG1 Redistributes Cell Cholesterol to Domains Removable by High Density Lipoprotein but Not by Lipid-depleted Apolipoproteins* , 2005, Journal of Biological Chemistry.
[30] D. Holtzman,et al. The Low Density Lipoprotein Receptor Regulates the Level of Central Nervous System Human and Murine Apolipoprotein E but Does Not Modify Amyloid Plaque Pathology in PDAPP Mice* , 2005, Journal of Biological Chemistry.
[31] Paul T. Tarr,et al. ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation. , 2005, Cell metabolism.
[32] Inder M Verma,et al. Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[33] M. Roth,et al. The Liver X Receptor Ligand T0901317 Decreases Amyloid β Production in Vitro and in a Mouse Model of Alzheimer's Disease* , 2004, Journal of Biological Chemistry.
[34] Xianlin Han,et al. ABCA1 Is Required for Normal Central Nervous System ApoE Levels and for Lipidation of Astrocyte-secreted apoE* , 2004, Journal of Biological Chemistry.
[35] L. Bernier,et al. Deficiency of ABCA1 Impairs Apolipoprotein E Metabolism in Brain* , 2004, Journal of Biological Chemistry.
[36] A. Tall,et al. ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[37] S. Paul,et al. Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides , 2004, Nature Medicine.
[38] L. Thal,et al. Impact of APOE genotype on neuropathologic and neurochemical markers of Alzheimer disease , 2004, Neurology.
[39] A. Tall,et al. Expression of Liver X Receptor Target Genes Decreases Cellular Amyloid β Peptide Secretion* , 2003, Journal of Biological Chemistry.
[40] M. Mercken,et al. Presenilin Redistribution Associated with Aberrant Cholesterol Transport Enhances β-Amyloid Production In Vivo , 2003, The Journal of Neuroscience.
[41] S. DeKosky,et al. 22R-Hydroxycholesterol and 9-cis-Retinoic Acid Induce ATP-binding Cassette Transporter A1 Expression and Cholesterol Efflux in Brain Cells and Decrease Amyloid β Secretion* , 2003, Journal of Biological Chemistry.
[42] Rudolph E. Tanzi,et al. Alzheimer's disease: the cholesterol connection , 2003, Nature Neuroscience.
[43] C. Haass,et al. Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts , 2003, The Journal of cell biology.
[44] L. Mucke,et al. Modulation of Alzheimer-Like Synaptic and Cholinergic Deficits in Transgenic Mice by Human Apolipoprotein E Depends on Isoform , Aging, and Overexpression of Amyloid β Peptides But Not on Plaque Formation , 2002, The Journal of Neuroscience.
[45] M. Irizarry,et al. Induction of the Cholesterol Transporter ABCA1 in Central Nervous System Cells by Liver X Receptor Agonists Increases Secreted Aβ Levels* , 2002, The Journal of Biological Chemistry.
[46] H. Hobbs,et al. Regulation of ATP-binding Cassette Sterol Transporters ABCG5 and ABCG8 by the Liver X Receptors α and β* , 2002, The Journal of Biological Chemistry.
[47] J. Leverenz,et al. Diet-induced hypercholesterolemia enhances brain A&bgr; accumulation in transgenic mice , 2002, Neuroreport.
[48] B. McManus,et al. ABCA1 mRNA and Protein Distribution Patterns Predict Multiple Different Roles and Levels of Regulation , 2002, Laboratory Investigation.
[49] S. Younkin,et al. Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains , 2002, Neurobiology of Disease.
[50] R. Allikmets,et al. Complete Characterization of the Human ABC Gene Family , 2001, Journal of bioenergetics and biomembranes.
[51] T. Langmann,et al. Role of ABCG1 and other ABCG family members in lipid metabolism. , 2001, Journal of lipid research.
[52] M. Gurney,et al. Human apolipoprotein E4 accelerates β‐amyloid deposition in APPsw transgenic mouse brain , 2001, Annals of neurology.
[53] A. Tall,et al. ATP-binding Cassette Transporter A1 (ABCA1) Functions as a Cholesterol Efflux Regulatory Protein* , 2001, The Journal of Biological Chemistry.
[54] E. Kojro,et al. Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10 , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[55] C. Bergmann,et al. Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[56] J. Dietschy,et al. Cholesterol metabolism in the brain , 2001, Current opinion in lipidology.
[57] J. Auwerx,et al. Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[58] H. Brewer,et al. Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. , 2001, Biochemical and biophysical research communications.
[59] A Rzhetsky,et al. The human ATP-binding cassette (ABC) transporter superfamily. , 2001, Journal of lipid research.
[60] D. Holtzman,et al. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. , 2000, The Journal of clinical investigation.
[61] B. Hyman,et al. Modulation of Aβ Deposition in APP Transgenic Mice by an Apolipoprotein E Null Background , 2000, Annals of the New York Academy of Sciences.
[62] G. Schmitz,et al. ABC transporters in cellular lipid trafficking , 2000, Current opinion in lipidology.
[63] G. Cole,et al. Influence of lipoproteins on microglial degradation of Alzheimer's amyloid beta‐protein , 2000, Microscopy research and technique.
[64] Rong Wang,et al. Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model , 2000, Neurobiology of Disease.
[65] A. Fagan,et al. Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model , 2000, Annals of neurology.
[66] A Rostagno,et al. Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides. , 2000, The Biochemical journal.
[67] A. Fagan,et al. Lipoproteins in the Central Nervous System , 2000, Annals of the New York Academy of Sciences.
[68] M. Hayden,et al. Cholesterol efflux regulatory protein, Tangier disease and familial high-density lipoprotein deficiency , 2000, Current opinion in lipidology.
[69] A. Fagan,et al. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[70] S. Paul,et al. Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[71] T. Langmann,et al. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease , 1999, Nature Genetics.
[72] C. Sensen,et al. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency , 1999, Nature Genetics.
[73] J. Piette,et al. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1 , 1999, Nature Genetics.
[74] A. Fagan,et al. Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease. , 1999, The Journal of clinical investigation.
[75] J. Wahren,et al. Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation. , 1998, Journal of lipid research.
[76] B. Strooper,et al. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[77] J. Price,et al. Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype. , 1998, Archives of neurology.
[78] D. Lütjohann,et al. Importance of a Novel Oxidative Mechanism for Elimination of Brain Cholesterol , 1997, The Journal of Biological Chemistry.
[79] J. Morris,et al. Clinical assessment of Alzheimer's disease , 1997, Neurology.
[80] C. Abraham,et al. Interaction of nascent ApoE2, ApoE3, and ApoE4 isoforms expressed in mammalian cells with amyloid peptide beta (1-40). Relevance to Alzheimer's disease. , 1997, Biochemistry.
[81] G. Webb,et al. Solvation Effects on the Conformational Behaviour of Gellan and Calcium Ion Binding to Gellan Double Helices , 1996 .
[82] E. Matsubara,et al. Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[83] P. Greengard,et al. Alzheimer Amyloid-β Peptide Forms Denaturant-Resistant Complex with Type ε3 but Not Type ε4 Isoform of Native Apolipoprotein E , 1996, Molecular medicine.
[84] W. Klein,et al. Cholesterol Modulates -Secretase Cleavage of Amyloid Precursor Protein (*) , 1996, The Journal of Biological Chemistry.
[85] A. Smith,et al. Influence of the apolipoprotein E genotype on amyloid deposition and neurofibrillary tangle formation in Alzheimer's disease , 1995, Neuroscience.
[86] G. Francis,et al. Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier Disease. , 1995, The Journal of clinical investigation.
[87] K. Umesono,et al. LXR, a nuclear receptor that defines a distinct retinoid response pathway. , 1995, Genes & development.
[88] G. Getz,et al. Purification of Apolipoprotein E Attenuates Isoform-specific Binding to -Amyloid (*) , 1995, The Journal of Biological Chemistry.
[89] B. Hyman,et al. Multiple, diverse senile plaque–associated proteins are ligands of an apolipoprotein e receptor, the α2‐macroglobulin receptor/low‐density‐lipoprotein receptor—related protein , 1995, Annals of neurology.
[90] G. Getz,et al. Isoform-specific binding of apolipoprotein E to beta-amyloid. , 1994, The Journal of biological chemistry.
[91] J. Nerbonne,et al. Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons. , 1994, The Journal of biological chemistry.
[92] A. M. Saunders,et al. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease , 1994, Nature Genetics.
[93] A D Roses,et al. Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[94] B. Hyman,et al. Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions , 1993, Neuron.
[95] J. Haines,et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. , 1993, Science.
[96] R. E. Pitas,et al. Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain. , 1987, The Journal of biological chemistry.
[97] M. Folstein,et al. Clinical diagnosis of Alzheimer's disease , 1984, Neurology.
[98] R. Mahley,et al. Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms. , 1981, The Journal of biological chemistry.
[99] J. Breslow,et al. Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification. , 1981, Biochemistry.
[100] T. Miida,et al. [Lipoproteins and their receptors in the central nervous system]. , 2009, Rinsho byori. The Japanese journal of clinical pathology.
[101] S. Paul,et al. Apolipoprotein is required for the formation of filamentous amyloid, but not for amorphous Abeta deposition, in an AbetaPP/PS double transgenic mouse model of Alzheimer's disease. , 2004, Journal of Alzheimer's Disease.
[102] A. Tall,et al. Expression of LXR target genes decreases cellular amyloid β peptide secretion , 2003 .
[103] J. Buxbaum,et al. Cholesterol depletion with physiological concentrations of a statin decreases the formation of the Alzheimer amyloid Abeta peptide. , 2001, Journal of Alzheimer's disease : JAD.
[104] D L Price,et al. Alzheimer's disease: genetic studies and transgenic models. , 1998, Annual review of genetics.
[105] S. Paul,et al. Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition. , 1997, Nature genetics.
[106] M A Pericak-Vance,et al. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. , 1993, Neurology.