Why lipids are important for Alzheimer disease?

[1]  A. Tall,et al.  ATP‐binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[2]  D. Holtzman,et al.  Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. , 2008, The Journal of clinical investigation.

[3]  Paul T. Tarr,et al.  ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2 Published, JLR Papers in Press, October 4, 2007. , 2008, Journal of Lipid Research.

[4]  L. Muglia,et al.  Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1 , 2007, Neuron.

[5]  A. Tall,et al.  High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1 , 2007, Proceedings of the National Academy of Sciences.

[6]  Peter Tontonoz,et al.  Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors , 2007, Proceedings of the National Academy of Sciences.

[7]  D. Holtzman,et al.  Transport Pathways for Clearance of Human Alzheimer's Amyloid β-Peptide and Apolipoproteins E and J in the Mouse Central Nervous System , 2007, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[8]  C. Wellington,et al.  The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of β-amyloid precursor protein Published, JLR Papers in Press, February 10, 2007. , 2007, Journal of Lipid Research.

[9]  M. Hayden,et al.  Physiologically regulated transgenic ABCA1 does not reduce amyloid burden or amyloid-beta peptide levels in vivo. , 2007, Journal of lipid research.

[10]  T. Comery,et al.  The LXR agonist TO901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer's disease , 2007, Molecular and Cellular Neuroscience.

[11]  T. V. van Berkel,et al.  Total Body ABCG1 Expression Protects Against Early Atherosclerotic Lesion Development in Mice , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[12]  A. Hill,et al.  Role of ABCG1 and ABCA1 in Regulation of Neuronal Cholesterol Efflux to Apolipoprotein E Discs and Suppression of Amyloid-β Peptide Generation* , 2007, Journal of Biological Chemistry.

[13]  A. Vaughan,et al.  ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL Published, JLR Papers in Press, August 10, 2006. , 2006, Journal of Lipid Research.

[14]  Paul T. Tarr,et al.  Deletion of the Transmembrane Transporter ABCG1 Results in Progressive Pulmonary Lipidosis* , 2006, Journal of Biological Chemistry.

[15]  K. Ueda,et al.  Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1s⃞ Published, JLR Papers in Press, May 15, 2006. , 2006, Journal of Lipid Research.

[16]  Lilit Vardanian,et al.  The effects of ABCA1 on cholesterol efflux and Aβ levels in vitro and in vivo , 2006, Journal of neurochemistry.

[17]  A. von Eckardstein,et al.  Lipid efflux by the ATP-binding cassette transporters ABCA1 and ABCG1. , 2006, Biochimica et biophysica acta.

[18]  A. Tall,et al.  LXR-Induced Redistribution of ABCG1 to Plasma Membrane in Macrophages Enhances Cholesterol Mass Efflux to HDL , 2006, Arteriosclerosis, thrombosis, and vascular biology.

[19]  P. Tontonoz,et al.  Liver X receptors as integrators of metabolic and inflammatory signaling. , 2006, The Journal of clinical investigation.

[20]  Barbara Karten,et al.  Expression of ABCG1, but Not ABCA1, Correlates with Cholesterol Release by Cerebellar Astroglia* , 2006, Journal of Biological Chemistry.

[21]  D. Mangelsdorf,et al.  LXRS and FXR: the yin and yang of cholesterol and fat metabolism. , 2006, Annual review of physiology.

[22]  Yadong Huang Apolipoprotein E and Alzheimer disease , 2006, Neurology.

[23]  Peter Tontonoz,et al.  Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia. , 2006, Annual review of medicine.

[24]  M. Hayden,et al.  The Absence of ABCA1 Decreases Soluble ApoE Levels but Does Not Diminish Amyloid Deposition in Two Murine Models of Alzheimer Disease* , 2005, Journal of Biological Chemistry.

[25]  D. Holtzman,et al.  Deletion of Abca1 Increases Aβ Deposition in the PDAPP Transgenic Mouse Model of Alzheimer Disease* , 2005, Journal of Biological Chemistry.

[26]  M. Staufenbiel,et al.  Lack of ABCA1 Considerably Decreases Brain ApoE Level and Increases Amyloid Deposition in APP23 Mice* , 2005, Journal of Biological Chemistry.

[27]  I. Gelissen,et al.  ABCA1 and ABCG1 Synergize to Mediate Cholesterol Export to ApoA-I , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[28]  J. Heinecke,et al.  ATP-binding cassette transporter A1: a cell cholesterol exporter that protects against cardiovascular disease. , 2005, Physiological reviews.

[29]  A. Vaughan,et al.  ABCG1 Redistributes Cell Cholesterol to Domains Removable by High Density Lipoprotein but Not by Lipid-depleted Apolipoproteins* , 2005, Journal of Biological Chemistry.

[30]  D. Holtzman,et al.  The Low Density Lipoprotein Receptor Regulates the Level of Central Nervous System Human and Murine Apolipoprotein E but Does Not Modify Amyloid Plaque Pathology in PDAPP Mice* , 2005, Journal of Biological Chemistry.

[31]  Paul T. Tarr,et al.  ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation. , 2005, Cell metabolism.

[32]  Inder M Verma,et al.  Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[33]  M. Roth,et al.  The Liver X Receptor Ligand T0901317 Decreases Amyloid β Production in Vitro and in a Mouse Model of Alzheimer's Disease* , 2004, Journal of Biological Chemistry.

[34]  Xianlin Han,et al.  ABCA1 Is Required for Normal Central Nervous System ApoE Levels and for Lipidation of Astrocyte-secreted apoE* , 2004, Journal of Biological Chemistry.

[35]  L. Bernier,et al.  Deficiency of ABCA1 Impairs Apolipoprotein E Metabolism in Brain* , 2004, Journal of Biological Chemistry.

[36]  A. Tall,et al.  ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[37]  S. Paul,et al.  Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides , 2004, Nature Medicine.

[38]  L. Thal,et al.  Impact of APOE genotype on neuropathologic and neurochemical markers of Alzheimer disease , 2004, Neurology.

[39]  A. Tall,et al.  Expression of Liver X Receptor Target Genes Decreases Cellular Amyloid β Peptide Secretion* , 2003, Journal of Biological Chemistry.

[40]  M. Mercken,et al.  Presenilin Redistribution Associated with Aberrant Cholesterol Transport Enhances β-Amyloid Production In Vivo , 2003, The Journal of Neuroscience.

[41]  S. DeKosky,et al.  22R-Hydroxycholesterol and 9-cis-Retinoic Acid Induce ATP-binding Cassette Transporter A1 Expression and Cholesterol Efflux in Brain Cells and Decrease Amyloid β Secretion* , 2003, Journal of Biological Chemistry.

[42]  Rudolph E. Tanzi,et al.  Alzheimer's disease: the cholesterol connection , 2003, Nature Neuroscience.

[43]  C. Haass,et al.  Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts , 2003, The Journal of cell biology.

[44]  L. Mucke,et al.  Modulation of Alzheimer-Like Synaptic and Cholinergic Deficits in Transgenic Mice by Human Apolipoprotein E Depends on Isoform , Aging, and Overexpression of Amyloid β Peptides But Not on Plaque Formation , 2002, The Journal of Neuroscience.

[45]  M. Irizarry,et al.  Induction of the Cholesterol Transporter ABCA1 in Central Nervous System Cells by Liver X Receptor Agonists Increases Secreted Aβ Levels* , 2002, The Journal of Biological Chemistry.

[46]  H. Hobbs,et al.  Regulation of ATP-binding Cassette Sterol Transporters ABCG5 and ABCG8 by the Liver X Receptors α and β* , 2002, The Journal of Biological Chemistry.

[47]  J. Leverenz,et al.  Diet-induced hypercholesterolemia enhances brain A&bgr; accumulation in transgenic mice , 2002, Neuroreport.

[48]  B. McManus,et al.  ABCA1 mRNA and Protein Distribution Patterns Predict Multiple Different Roles and Levels of Regulation , 2002, Laboratory Investigation.

[49]  S. Younkin,et al.  Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains , 2002, Neurobiology of Disease.

[50]  R. Allikmets,et al.  Complete Characterization of the Human ABC Gene Family , 2001, Journal of bioenergetics and biomembranes.

[51]  T. Langmann,et al.  Role of ABCG1 and other ABCG family members in lipid metabolism. , 2001, Journal of lipid research.

[52]  M. Gurney,et al.  Human apolipoprotein E4 accelerates β‐amyloid deposition in APPsw transgenic mouse brain , 2001, Annals of neurology.

[53]  A. Tall,et al.  ATP-binding Cassette Transporter A1 (ABCA1) Functions as a Cholesterol Efflux Regulatory Protein* , 2001, The Journal of Biological Chemistry.

[54]  E. Kojro,et al.  Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10 , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[55]  C. Bergmann,et al.  Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[56]  J. Dietschy,et al.  Cholesterol metabolism in the brain , 2001, Current opinion in lipidology.

[57]  J. Auwerx,et al.  Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[58]  H. Brewer,et al.  Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. , 2001, Biochemical and biophysical research communications.

[59]  A Rzhetsky,et al.  The human ATP-binding cassette (ABC) transporter superfamily. , 2001, Journal of lipid research.

[60]  D. Holtzman,et al.  Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. , 2000, The Journal of clinical investigation.

[61]  B. Hyman,et al.  Modulation of Aβ Deposition in APP Transgenic Mice by an Apolipoprotein E Null Background , 2000, Annals of the New York Academy of Sciences.

[62]  G. Schmitz,et al.  ABC transporters in cellular lipid trafficking , 2000, Current opinion in lipidology.

[63]  G. Cole,et al.  Influence of lipoproteins on microglial degradation of Alzheimer's amyloid beta‐protein , 2000, Microscopy research and technique.

[64]  Rong Wang,et al.  Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model , 2000, Neurobiology of Disease.

[65]  A. Fagan,et al.  Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model , 2000, Annals of neurology.

[66]  A Rostagno,et al.  Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides. , 2000, The Biochemical journal.

[67]  A. Fagan,et al.  Lipoproteins in the Central Nervous System , 2000, Annals of the New York Academy of Sciences.

[68]  M. Hayden,et al.  Cholesterol efflux regulatory protein, Tangier disease and familial high-density lipoprotein deficiency , 2000, Current opinion in lipidology.

[69]  A. Fagan,et al.  Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[70]  S. Paul,et al.  Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[71]  T. Langmann,et al.  The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease , 1999, Nature Genetics.

[72]  C. Sensen,et al.  Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency , 1999, Nature Genetics.

[73]  J. Piette,et al.  Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1 , 1999, Nature Genetics.

[74]  A. Fagan,et al.  Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease. , 1999, The Journal of clinical investigation.

[75]  J. Wahren,et al.  Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation. , 1998, Journal of lipid research.

[76]  B. Strooper,et al.  Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[77]  J. Price,et al.  Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype. , 1998, Archives of neurology.

[78]  D. Lütjohann,et al.  Importance of a Novel Oxidative Mechanism for Elimination of Brain Cholesterol , 1997, The Journal of Biological Chemistry.

[79]  J. Morris,et al.  Clinical assessment of Alzheimer's disease , 1997, Neurology.

[80]  C. Abraham,et al.  Interaction of nascent ApoE2, ApoE3, and ApoE4 isoforms expressed in mammalian cells with amyloid peptide beta (1-40). Relevance to Alzheimer's disease. , 1997, Biochemistry.

[81]  G. Webb,et al.  Solvation Effects on the Conformational Behaviour of Gellan and Calcium Ion Binding to Gellan Double Helices , 1996 .

[82]  E. Matsubara,et al.  Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[83]  P. Greengard,et al.  Alzheimer Amyloid-β Peptide Forms Denaturant-Resistant Complex with Type ε3 but Not Type ε4 Isoform of Native Apolipoprotein E , 1996, Molecular medicine.

[84]  W. Klein,et al.  Cholesterol Modulates -Secretase Cleavage of Amyloid Precursor Protein (*) , 1996, The Journal of Biological Chemistry.

[85]  A. Smith,et al.  Influence of the apolipoprotein E genotype on amyloid deposition and neurofibrillary tangle formation in Alzheimer's disease , 1995, Neuroscience.

[86]  G. Francis,et al.  Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier Disease. , 1995, The Journal of clinical investigation.

[87]  K. Umesono,et al.  LXR, a nuclear receptor that defines a distinct retinoid response pathway. , 1995, Genes & development.

[88]  G. Getz,et al.  Purification of Apolipoprotein E Attenuates Isoform-specific Binding to -Amyloid (*) , 1995, The Journal of Biological Chemistry.

[89]  B. Hyman,et al.  Multiple, diverse senile plaque–associated proteins are ligands of an apolipoprotein e receptor, the α2‐macroglobulin receptor/low‐density‐lipoprotein receptor—related protein , 1995, Annals of neurology.

[90]  G. Getz,et al.  Isoform-specific binding of apolipoprotein E to beta-amyloid. , 1994, The Journal of biological chemistry.

[91]  J. Nerbonne,et al.  Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons. , 1994, The Journal of biological chemistry.

[92]  A. M. Saunders,et al.  Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease , 1994, Nature Genetics.

[93]  A D Roses,et al.  Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[94]  B. Hyman,et al.  Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions , 1993, Neuron.

[95]  J. Haines,et al.  Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. , 1993, Science.

[96]  R. E. Pitas,et al.  Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain. , 1987, The Journal of biological chemistry.

[97]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease , 1984, Neurology.

[98]  R. Mahley,et al.  Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms. , 1981, The Journal of biological chemistry.

[99]  J. Breslow,et al.  Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification. , 1981, Biochemistry.

[100]  T. Miida,et al.  [Lipoproteins and their receptors in the central nervous system]. , 2009, Rinsho byori. The Japanese journal of clinical pathology.

[101]  S. Paul,et al.  Apolipoprotein is required for the formation of filamentous amyloid, but not for amorphous Abeta deposition, in an AbetaPP/PS double transgenic mouse model of Alzheimer's disease. , 2004, Journal of Alzheimer's Disease.

[102]  A. Tall,et al.  Expression of LXR target genes decreases cellular amyloid β peptide secretion , 2003 .

[103]  J. Buxbaum,et al.  Cholesterol depletion with physiological concentrations of a statin decreases the formation of the Alzheimer amyloid Abeta peptide. , 2001, Journal of Alzheimer's disease : JAD.

[104]  D L Price,et al.  Alzheimer's disease: genetic studies and transgenic models. , 1998, Annual review of genetics.

[105]  S. Paul,et al.  Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition. , 1997, Nature genetics.

[106]  M A Pericak-Vance,et al.  Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. , 1993, Neurology.