Synthesis of a new water-soluble octa-cationic phthalocyanine derivative for PDT

The synthesis and characterization of a new octa-cationic Zn‐phthalocyanine is described. This compound is water-soluble, not aggregated under a wide range of solvent conditions and is a powerful photosensitizer for the inactivation of microorganisms by using a strategy based on photodynamic therapy. © 2000 Elsevier Science Ltd. All rights reserved.

[1]  L. Dicelio,et al.  Synthesis and photophysical properties of a new cationic water-soluble Zn phthalocyanine. , 1997, Journal of photochemistry and photobiology. B, Biology.

[2]  Stanley B. Brown,et al.  Some observations on the synthesis of polysubstituted zinc phthalocyanine sensitisers for photodynamic therapy , 1997 .

[3]  M. Ochsner.  Photophysical and photobiological processes in the photodynamic therapy of tumours. , 1997, Journal of photochemistry and photobiology. B, Biology.

[4]  G Graschew,et al.  SYNTHESIS OF POSITIVELY CHARGED PHTHALOCYANINES and THEIR ACTIVITY IN THE PHOTODYNAMIC THERAPY OF CANCER CELLS , 1990, Photochemistry and photobiology.

[5]  R. P. Seiders,et al.  Dimerization of cobalt(II) tetrasulfonated phthalocyanine in water and aqueous alcoholic solutions , 1985 .

[6]  M. Wainwright,et al.  A study of photobactericidal activity in the phenothiazinium series. , 1997, FEMS immunology and medical microbiology.

[7]  G. Jori,et al.  Tumour photosensitizers: approaches to enhance the selectivity and efficiency of photodynamic therapy. , 1996, Journal of photochemistry and photobiology. B, Biology.

[8]  H. Zimmermann,et al.  Selective photosensitization of mitochondria in HeLa cells by cationic Zn (II) phthalocyanines with lipophilic side-chains. , 1997, Journal of photochemistry and photobiology. B, Biology.

[9]  Arthur W. Snow,et al.  Simultaneous electrical conductivity and piezoelectric mass measurements on iodine-doped phthalocyanine Langmuir-Blodgett films , 1986 .

[10]  A. Grund,et al.  Resonant nonlinear optical properties of spin-cast films of soluble oligomeric bridged (phthalocyaninato)ruthenium(II) complexes , 1992 .

[11]  J. Simon,et al.  Annelides. 7. Discotic mesophases obtained from substituted metallophthalocyanines. Toward liquid crystalline one-dimensional conductors , 1982 .

[12]  M. Murphy,et al.  Selective targeting of bioactive compounds to mitochondria. , 1997, Trends in biotechnology.